Egg-yolk core–shell mesoporous silica nanoparticles for high doxorubicin loading and delivery to prostate cancer cells

Tiburcius, Steffi; Krishnan, Kannan; Jose, Linta; Patel, Vaishwik; Ghosh, Arnab; Sathish, Clastin I.; Weidenhofer, Judith; Yang, Jae‐Hun; Verrills, Nicole M.; Karakoti, Ajay; Vinu, Ajayan

doi:10.1039/d2nr00783e

Cited by 11 publications

(3 citation statements)

References 77 publications

(94 reference statements)

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“…[ 46 ] Higher loading efficiencies were achieved by increasing the surface area of NPs, which is a non‐tuneable parameter for naturally porous DNPs. [ 47,48 ] We reported in a previous work that DNPs‐Gel having a lower galunisertib loading capacity of 2% ± 0.4% inhibited the metastatic signaling in CRC efficiently. [ 13 ] Here, a higher loading capacity of 4% ± 0.2% was achieved by increasing the concentration of gelatin in the outer shell, as suggested by previous results.…”

Section: Resultsmentioning

confidence: 99%

Microfluidic‐Assisted Production of Gastro‐Resistant Active‐Targeted Diatomite Nanoparticles for the Local Release of Galunisertib in Metastatic Colorectal Cancer Cells

Tramontano

Martins

Stefano

et al. 2022

Adv Healthcare Materials

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The oral route is highly desirable for colorectal cancer (CRC) treatment because it allows concentrating the drug in the colon and achieving a localized effect. However, orally administered drugs are often metabolized in the liver, resulting in reduced efficacy and the need for higher doses. Nanoparticle-based drug delivery systems can be engineered to prevent the diffusion of the drug in the stomach, addressing the release at the target site, and enhancing the efficacy of the delivered drug. Here, an orally administrable galunisertib delivery system is developed with gelatin-covered diatomite nanoparticles targeting the ligand 1-cell adhesion molecule (L1-CAM) on metastatic cells, and further encapsulated in an enteric matrix by microfluidics. The gastro-resistant polymer protects the nanoparticles from the action of the digestive enzymes and allows for a sustained release of galunisertib at the intestinal pH. The efficacy of antibody-antigen interactions to drive the internalization of nanoparticles in the targeted cells is investigated in CRC cells expressing abnormal (SW620) or basal levels (Caco-2, HT29-MTX) of L1-CAM. The combination of local drug release and active targeting enhances the effect of the delivered galunisertib, which inhibits the migration of the SW620 cells with greater efficiency compared to the free drug.

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Section: Resultsmentioning

confidence: 99%

Microfluidic‐Assisted Production of Gastro‐Resistant Active‐Targeted Diatomite Nanoparticles for the Local Release of Galunisertib in Metastatic Colorectal Cancer Cells

Tramontano

Martins

Stefano

et al. 2022

Adv Healthcare Materials

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“…In Australia, prostate cancer stands as the third most common cause of death attributed to cancer and remains the second most prevalent disease among men. [19,20,22,172] It is classified as either acinar adenocarcinoma or ductal adenocarcinoma. Acinar adenocarcinoma originates from gland cells that line the prostate gland, whereas ductal adenocarcinoma tends to spread at a faster rate than acinar adenocarcinoma, which arises in cells lining the ducts of the prostate gland.…”

Section: Prostate Cancermentioning

confidence: 99%

“…In this regard, early cancer detection becomes a life-saving support for patients to accelerate various treatment processes including nanodrug delivery. [4,[17][18][19][20][21][22][23] A sensitive and accurate cancer diagnosis is a highly efficient approach for enhancing their chances of survival, particularly in developing countries. [24][25][26] Conventional cancer diagnosis methods typically employ noninvasive nuclear-based imaging techniques, including magnetic resonance imaging (MRI), computed tomography (CT), ultrasonography, positron emission tomography (PET), and single-photon emission computed tomography.…”

Section: Introductionmentioning

confidence: 99%

Emerging Multifunctional Carbon‐Nanomaterial‐Based Biosensors for Cancer Diagnosis

Britto,

Guan,

Tran

et al. 2024

Small Science

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Despite significant advancements in medical technology, cancer remains the world's second‐leading cause of death, largely attributed to late‐stage diagnoses. While traditional cancer detection methodologies offer foundational insights, they often lack the specificity, affordability, and sensitivity for early‐stage identification. In this context, the development of biosensors offers a distinct possibility for the precise and rapid identification of cancer biomarkers. Carbon nanomaterials, including graphene, carbon nitride, carbon quantum dots, and other carbon‐based nanostructures, are highly promising for cancer detection. Their simplicity, high sensitivity, and cost‐effectiveness contribute to their potential in this field. This review aims to elucidate the potential of emerging carbon‐nanomaterial‐based biosensors for early cancer diagnosis. The relevance of the various biosensor mechanisms and their performance to the physicochemical properties of carbon nanomaterials is discussed in depth, focusing on demonstrating broad methodologies for creating performance biosensors. Diverse carbon‐nanomaterial‐based detection techniques, such as electrochemical, fluorescence, surface plasmon resonance, electrochemiluminescence, and quartz crystal microbalance, are emphasized for early cancer detection. At last, a summary of existing challenges and future outlook in this promising field is elaborated.

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Stimuli‐Responsive Silica Silanol Conjugates: Strategic Nanoarchitectonics in Targeted Drug Delivery

Mohanan

Guan

Liang

et al. 2023

Small

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The design of novel drug delivery systems is exceptionally critical in disease treatments. Among the existing drug delivery systems, mesoporous silica nanoparticles (MSNs) have shown profuse promise owing to their structural stability, tunable morphologies/sizes, and ability to load different payload chemistry. Significantly, the presence of surface silanol groups enables functionalization with relevant drugs, imaging, and targeting agents, promoting their utility and popularity among researchers. Stimuli‐responsive silanol conjugates have been developed as a novel, more effective way to conjugate, deliver, and release therapeutic drugs on demand and precisely to the selected location. Therefore, it is urgent to summarize the current understanding and the surface silanols’ role in making MSN a versatile drug delivery platform. This review provides an analytical understanding of the surface silanols, chemistry, identification methods, and their property–performance correlation. The chemistry involved in converting surface silanols to a stimuli‐responsive silica delivery system by endogenous/exogenous stimuli, including pH, redox potential, temperature, and hypoxia, is discussed in depth. Different chemistries for converting surface silanols to stimuli‐responsive bonds are discussed in the context of drug delivery. The critical discussion is culminated by outlining the challenges in identifying silanols’ role and overcoming the limitations in synthesizing stimuli‐responsive mesoporous silica‐based drug delivery systems.

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Egg-yolk core–shell mesoporous silica nanoparticles for high doxorubicin loading and delivery to prostate cancer cells

Abstract: Mesoporous silica-based nanoparticle (MSN) has gained rapid interest as drug delivery system (DDS) and demonstrated its versatility in the delivering drugs for the treatment of various cancers. However, the drug...

Cited by 11 publications

References 77 publications

Microfluidic‐Assisted Production of Gastro‐Resistant Active‐Targeted Diatomite Nanoparticles for the Local Release of Galunisertib in Metastatic Colorectal Cancer Cells

Microfluidic‐Assisted Production of Gastro‐Resistant Active‐Targeted Diatomite Nanoparticles for the Local Release of Galunisertib in Metastatic Colorectal Cancer Cells

Emerging Multifunctional Carbon‐Nanomaterial‐Based Biosensors for Cancer Diagnosis

Stimuli‐Responsive Silica Silanol Conjugates: Strategic Nanoarchitectonics in Targeted Drug Delivery

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