Mesoporous silica encapsulation of silicon nanocrystals: Synthesis, aqueous dispersibility and drug release

Regli, Sarah; Kelly, Joel A.; Barnes, Marie A.; Andrei, Carmen; Veinot, Jonathan G. C.

doi:10.1016/j.matlet.2013.10.006

Cited by 11 publications

(17 citation statements)

References 48 publications

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“…16 Building on our earlier work, we propose that the presented ligand exchange reactions proceed via the mechanism summarized in In support of this proposed mechanism, we performed a model molecular reactions. The first saw tetramethoxysilane (TMOS) being treated with BH 3 •THF under microwave irradiation at 150 °C and resulted in the production of trimethoxyborane that was confirmed by 11 B NMR with chemical shift of 18.5 ppm (Figure S9). The expected silconbased product (i.e., SiH 4 ) is a reactive gas and was not detected by NMR.…”

Section: ■ Results and Discussionmentioning

confidence: 93%

“…As is the case for most semiconductors, silicon exhibits intriguing size-dependent properties when prepared on the nanoscale that have facilitated the development of prototype applications in many areas including electronics, photonics, photovoltaics, , and catalysis . In addition to particle size, surface chemistry offers another degree of freedom that provides tailoring of silicon quantum dot (SiQD) properties. − SiQDs have also garnered attention because of the promise of low cytotoxicity, which makes them well-suited as theranostic materials. − If the full practical potential of SiQDs is to be realized they must be effectively interfaced with their surroundings (e.g., solubility) and rendered resistant toward deleterious and unwanted reactions (e.g., oxidation) . To this end, establishing convenient methods for passivating and derivatizing SiQD surfaces to obtain functional (even “designer”) materials for practical or relevant industrial applications is of paramount importance.…”

Section: Introductionmentioning

confidence: 99%

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Alkoxy-Terminated Si Surfaces: A New Reactive Platform for the Functionalization and Derivatization of Silicon Quantum Dots

et al. 2016

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Alkoxy-terminated silicon quantum dots (SiQDs) were synthesized via hydrosilylation of aliphatic ketones on hydride-terminated SiQD (H-SiQD) surfaces under microwave-irradiation. Aromatic ketones undergo hydrosilylation on H-SiQD surfaces at room temperature without requiring any catalyst. The alkoxy-terminated SiQDs are soluble in organic solvents, colloidally stable, and show bright and size dependent photoluminescence (PL). The alkoxy-functionalized silicon surfaces were used as reactive platform for further functionalization via unprecedented ligand exchange of the alkoxy-surface groups with alkyl or alkenyl-surface groups in the presence of BH3·THF. Proton nuclear magnetic resonance ((1)H NMR), Fourier transform infrared (FTIR), and X-ray photoelectron spectroscopy (XPS) spectroscopy confirmed alkoxy-terminated surfaces and their ligand exchange reactions in the presence of various alkenes and alkynes.

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Section: ■ Results and Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Alkoxy-Terminated Si Surfaces: A New Reactive Platform for the Functionalization and Derivatization of Silicon Quantum Dots

et al. 2016

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“…The percentage of hemolysis of Si NC-MPM (<2%) is in the safe range. Regli et al 105 encapsulated Si NCs into mesoporous a silica nanosphere to make it soluble in an aqueous environment. This composite could carry a large amount of ibuprofen into the structures of mesopores and release it slowly over a period of days.…”

Section: ■ Fluorescence Meachanism Of Silicon Nanocrystal Compositesmentioning

confidence: 99%

Silicon Nanocrystals and Their Composites: Syntheses, Fluorescence Mechanisms, and Biological Applications

Liang

Huang

Gong

2019

ACS Sustainable Chem. Eng.

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Due to excellent fluorescence intensity, low toxicity, good biocompatibility and stability, silicon nanocrystals (Si NCs) and Si NCs-based composites have attracted extensive attention and have been widely applied in analytical detection, biomarkers, photocatalysts, photodiodes, and solar cells. In this perspective, we summarize the recent advances in the synthesis of Si NCs and their composites and also discuss their fluorescence property and mechanism in detail. We also introduce their biological applications. Finally, the outlooks and future challenges of the promising research field are briefly discussed. This perspective is hoped to make a contribution to the subsequent synthesis and biological applications of Si NCs and their composites.

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“…200,221,222,261 Formation of a silica layer increases the colloidal stability of Si NCs in water. 262 Nevertheless simple stabilization by surface oxidation does not provide long-term resistant luminescent materials as achievable with other capping agents. On the other hand, controlled biodegradation of Si QDs may become valuable in their application to in vivo imaging to avoid irreversible accumulation of the NPs in the organism.…”

Section: And Plasmamentioning

confidence: 99%

Nanodiamonds and silicon quantum dots: ultrastable and biocompatible luminescent nanoprobes for long-term bioimaging

2015

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Fluorescence bioimaging is a powerful, versatile, method for investigating, both in vivo and in vitro, the complex structures and functions of living organisms in real time and space, also using super-resolution techniques. Being poorly invasive, fluorescence bioimaging is suitable for long-term observation of biological processes. Long-term detection is partially prevented by photobleaching of organic fluorescent probes. Semiconductor quantum dots, in contrast, are ultrastable, fluorescent contrast agents detectable even at the single nanoparticle level. Emission color of quantum dots is size dependent and nanoprobes emitting in the near infrared (NIR) region are ideal for low back-ground in vivo imaging. Biocompatibility of nanoparticles, containing toxic elements, is debated. Recent safety concerns enforced the search for alternative ultrastable luminescent nanoprobes. Most recent results demonstrated that optimized silicon quantum dots (Si QDs) and fluorescent nanodiamonds (FNDs) show almost no photobleaching in a physiological environment. Moreover in vitro and in vivo toxicity studies demonstrated their unique biocompatibility. Si QDs and FNDs are hence ideal diagnostic tools and promising non-toxic vectors for the delivery of therapeutic cargos. Most relevant examples of applications of Si QDs and FNDs to long-term bioimaging are discussed in this review comparing the toxicity and the stability of different nanoprobes.

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Mesoporous silica encapsulation of silicon nanocrystals: Synthesis, aqueous dispersibility and drug release

Cited by 11 publications

References 48 publications

Alkoxy-Terminated Si Surfaces: A New Reactive Platform for the Functionalization and Derivatization of Silicon Quantum Dots

Alkoxy-Terminated Si Surfaces: A New Reactive Platform for the Functionalization and Derivatization of Silicon Quantum Dots

Silicon Nanocrystals and Their Composites: Syntheses, Fluorescence Mechanisms, and Biological Applications

Nanodiamonds and silicon quantum dots: ultrastable and biocompatible luminescent nanoprobes for long-term bioimaging

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