Mesoporous silica coated CeO<sub>2</sub> nanozymes with combined lipid-lowering and antioxidant activity induce long-term improvement of the metabolic profile in obese Zucker rats

Parra‐Robert, Marina; Zeng, Muling; Shu, Ying; Fernández‐Varo, Guillermo; Perramón, Meritxell; Desai, Dawood; Chen, Junhao; Guo, Dan; Zhang, Xu; Morales-Ruíz, Manuel; Rosenholm, Jessica M.; Jiménez, Wladimiro; Puntes, Víctor; Casals, Eudald; Casals, Gregori

doi:10.1039/d1nr00790d

Cited by 15 publications

(20 citation statements)

References 55 publications

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“…Treated rats presented a lower body weight and reduced circulating levels of insulin, leptin, glucose, and triglycerides. In comparison, recent data from our lab [94] found lower circulating triglyceride levels in 14-week-old obese Zucker rats treated with CeO 2 NPS (0.1 mg/kg twice weekly in weeks 8 and 9; 4 nm) but did not find significant effects on the body weight or circulating levels of insulin and glucose. In addition, no significant effects of CeO 2 NPs on liver fat accumulation were observed by hepatic oil red staining or lipidomic analysis.…”

Section: Liver Steatosiscontrasting

confidence: 77%

Cerium Oxide Nanoparticles: A New Therapeutic Tool in Liver Diseases

Casals¹,

Perramón²,

Casals

et al. 2021

Antioxidants

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Oxidative stress induced by the overproduction of free radicals or reactive oxygen species (ROS) has been considered as a key pathogenic mechanism contributing to the initiation and progression of injury in liver diseases. Consequently, during the last few years antioxidant substances, such as superoxide dismutase (SOD), resveratrol, colchicine, eugenol, and vitamins E and C have received increasing interest as potential therapeutic agents in chronic liver diseases. These substances have demonstrated their efficacy in equilibrating hepatic ROS metabolism and thereby improving liver functionality. However, many of these agents have not successfully passed the scrutiny of clinical trials for the prevention and treatment of various diseases, mainly due to their unspecificity and consequent uncontrolled side effects, since a minimal level of ROS is needed for normal functioning. Recently, cerium oxide nanoparticles (CeO2NPs) have emerged as a new powerful antioxidant agent with therapeutic properties in experimental liver disease. CeO2NPs have been reported to act as a ROS and reactive nitrogen species (RNS) scavenger and to have multi-enzyme mimetic activity, including SOD activity (deprotionation of superoxide anion into oxygen and hydrogen peroxide), catalase activity (conversion of hydrogen peroxide into oxygen and water), and peroxidase activity (reducing hydrogen peroxide into hydroxyl radicals). Consequently, the beneficial effects of CeO2NPs treatment have been reported in many different medical fields other than hepatology, including neurology, ophthalmology, cardiology, and oncology. Unlike other antioxidants, CeO2NPs are only active at pathogenic levels of ROS, being inert and innocuous in healthy cells. In the current article, we review the potential of CeO2NPs in several experimental models of liver disease and their safety as a therapeutic agent in humans as well.

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Section: Liver Steatosiscontrasting

confidence: 77%

Cerium Oxide Nanoparticles: A New Therapeutic Tool in Liver Diseases

Casals¹,

Perramón²,

Casals

et al. 2021

Antioxidants

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“…Surface modification ranging from functional group, inorganic ions and small molecules to macromolecules has been revealed as a promising strategy to regulate the mimetic enzyme properties of metal-and metal oxide-based nanozymes by affecting their surface chemistry [247][248][249]. For instance, ligands such as glutathione (GSH), dendrimer, DNA, and protein tend to protect metal nanoclusters from aggregation, thence reinforcing the stability, biocompatibility and catalytic activity of nanozymes [250,251].…”

Section: Surface Modificationmentioning

confidence: 99%

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

et al. 2021

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Since the ferromagnetic (Fe3O4) nanoparticles were firstly reported to exert enzyme-like activity in 2007, extensive research progress in nanozymes has been made with deep investigation of diverse nanozymes and rapid development of related nanotechnologies. As promising alternatives for natural enzymes, nanozymes have broadened the way toward clinical medicine, food safety, environmental monitoring, and chemical production. The past decade has witnessed the rapid development of metal- and metal oxide-based nanozymes owing to their remarkable physicochemical properties in parallel with low cost, high stability, and easy storage. It is widely known that the deep study of catalytic activities and mechanism sheds significant influence on the applications of nanozymes. This review digs into the characteristics and intrinsic properties of metal- and metal oxide-based nanozymes, especially emphasizing their catalytic mechanism and recent applications in biological analysis, relieving inflammation, antibacterial, and cancer therapy. We also conclude the present challenges and provide insights into the future research of nanozymes constituted of metal and metal oxide nanomaterials.

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“…Robert [ 20 ] has reported that the ultraviolet-visible (UV-Vis) spectra of CeO 2 -NPs core before and after mSiO 2 coating are similar, confirming that the initial CeO2-NPs coating was successful and NP aggregation or degradation not induced. Importantly, in contrast to uncoated CeO 2 -NPs, mSiO 2 coating allowed colloidal stability in physiological media.…”

Section: Resultsmentioning

confidence: 97%

Multifunctional mesoporous silica-cerium oxide nanozymes facilitate miR129 delivery for high-quality healing of radiation-induced skin injury

Zhou

Du²,

Luo³

et al. 2022

J Nanobiotechnol

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Radiation-induced skin injury (RISI) is an important challenge for clinical treatments. The main causes of RISI include hypoxia in the wound microenvironment, reactive oxygen species (ROS) activation, and downregulation of DNA repair proteins. Here, a multiple radioresistance strategy was designed for microRNA therapy and attenuating hypoxia. A novel mesoporous silica (MS) firmly anchored and dispersed cerium (IV) oxide (CeO2) nanoparticles to form MS-CeO2 nanocomposites, which exhibit superior activity in inhibiting radiation-induced ROS and HIF-1α activation and ultimately promote RISI wound healing. The miR129 serum concentrations in patients can promote radioresistance by directly targeting RAD17 and regulating the Chk2 pathway. Subsequently, MS-CeO2 nanocomposites with miR129 were conjugated with iRGD-grafted polyoxyethylene glycol (short for nano-miR129), which increased the stability and antibacterial character, efficiently delivered miR129 to wound blood capillaries, and exhibited low toxicity. Notably, nano-miR129 promoted radioresistance and enhanced anti-ROS therapeutic efficacy in a subcutaneous RISI mouse model. Overall, this MS-CeO2 nanozyme and miR129-based multiresistance radiotherapy protection strategy provided a promising therapeutic approach for RISI.

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Mesoporous silica coated CeO₂ nanozymes with combined lipid-lowering and antioxidant activity induce long-term improvement of the metabolic profile in obese Zucker rats

Abstract: Obesity is one of the most important public health problems that is associated to an array of metabolic disorders linked to cardiovascular disease, stroke, type 2 diabetes, and cancer. A...

Cited by 15 publications

References 55 publications

Cerium Oxide Nanoparticles: A New Therapeutic Tool in Liver Diseases

Cerium Oxide Nanoparticles: A New Therapeutic Tool in Liver Diseases

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

Multifunctional mesoporous silica-cerium oxide nanozymes facilitate miR129 delivery for high-quality healing of radiation-induced skin injury

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Mesoporous silica coated CeO2 nanozymes with combined lipid-lowering and antioxidant activity induce long-term improvement of the metabolic profile in obese Zucker rats

Abstract: Obesity is one of the most important public health problems that is associated to an array of metabolic disorders linked to cardiovascular disease, stroke, type 2 diabetes, and cancer. A...

Cited by 15 publications

References 55 publications

Cerium Oxide Nanoparticles: A New Therapeutic Tool in Liver Diseases

Cerium Oxide Nanoparticles: A New Therapeutic Tool in Liver Diseases

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

Multifunctional mesoporous silica-cerium oxide nanozymes facilitate miR129 delivery for high-quality healing of radiation-induced skin injury

Contact Info

Product

Resources

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Mesoporous silica coated CeO₂ nanozymes with combined lipid-lowering and antioxidant activity induce long-term improvement of the metabolic profile in obese Zucker rats