Mesoporous silica-based bioactive glasses for antibiotic-free antibacterial applications

Kaya, Seray; Cresswell, Mark; Boccaccını, Aldo R.

doi:10.1016/j.msec.2017.11.003

Cited by 150 publications

(101 citation statements)

References 120 publications

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“…A variety of surface modification techniques have been applied to improve the surface properties of titanium and its alloys, including physical vapour deposition, sol-gel, ion implantation, anodic oxidation and micro-arc oxidation (MAO) [6][7][8][9][10]. MAO is a relatively simple and efficient technology for the growth of porous oxide ceramic coatings with high bonding strength in situ, and it has been widely applied in the surface modification of Ti and its alloys [11,12].…”

Section: Introductionmentioning

confidence: 99%

Effect of titanium implants with coatings of different pore sizes on adhesion and osteogenic differentiation of BMSCs

Zhou

Huang

Gan

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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A variety of surface modification methods are applied to modify titanium implants to improve their biological activity. Micro-arc oxidation (MAO) can relatively simply and efficiently produce porous coatings with high bioactivity and bond strength on titanium surfaces. However, there is no conclusion about the effect of coatings with different pore sizes produced by MAO on bone marrow mesenchymal stem cells (BMSCs). To study the effect of different pore sizes on BMSCs, rat BMSCs were applied to detect the effect of different pore sizes prepared by MAO on cell adhesion and osteogenic differentiation. Three groups of coatings with different pore sizes were successfully prepared, and the pore size was within the range of 3-10 mm. Importantly, the expression of adhesion-related protein integrin b1 and osteogenic-related proteins OSX and ALP increased along with the increase in pore size. This study showed that the porous coating prepared by MAO promotes BMSCs adhesion and osteogenic differentiation. It reveals that the pore size is in the range of 3-10 mm and the larger pores are more beneficial for BMSCs adhesion and osteogenic differentiation. This study is instructive for optimizing the design of biomedical implant surfaces.

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Section: Introductionmentioning

confidence: 99%

Effect of titanium implants with coatings of different pore sizes on adhesion and osteogenic differentiation of BMSCs

Zhou

Huang

Gan

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…These unique features make MBGs optimal candidates to be used as local drug-delivery systems for drugs, biomolecules, or therapeutic metallic ions [ 6 , 7 , 9 ]. In the last decades, several metallic ions such as copper, gallium, strontium, silver, cobalt, cerium, and zinc have been incorporated in bioactive glasses to enhance bone formation due to their effect on osteogenesis and angiogenesis [ 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Silver-Doped Mesoporous Bioactive Glass and Its Applications in Conjunction with Electrospinning

et al. 2018

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Since they were first developed in 2004, mesoporous bioactive glasses (MBGs) rapidly captured the interest of the scientific community thanks to their numerous beneficial properties. MBGs are synthesised by a combination of the sol–gel method with the chemistry of surfactants to obtain highly mesoporous (pore size from 5 to 20 nm) materials that, owing to their high surface area and ordered structure, are optimal candidates for controlled drug-delivery systems. In this work, we synthesised and characterised a silver-containing mesoporous bioactive glass (Ag-MBG). It was found that Ag-MBG is a suitable candidate for controlled drug delivery, showing a perfectly ordered mesoporous structure ideal for the loading of drugs together with optimal bioactivity, sustained release of silver from the matrix, and fast and strong bacterial inhibition against both Gram-positive and Gram-negative bacteria. Silver-doped mesoporous glass particles were used in three electrospinning-based techniques to produce PCL/Ag-MBG composite fibres, to coat bioactive glass scaffolds (via electrospraying), and for direct sol electrospinning. The results obtained in this study highlight the versatility and efficacy of Ag-substituted mesoporous bioactive glass and encourage further studies to characterize the biological response to Ag-MBG-based antibacterial controlled-delivery systems for tissue-engineering applications.

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“… 24 , 25 Third, bioactive glasses can be antimicrobial themselves and have been shown to be bactericidal either alone or when doped with trace quantities of elements known to have antimicrobial effects such as silver, gallium, or iodine. 26 - 28 …”

Section: Introductionmentioning

confidence: 99%

Antibiotic Elution and Mechanical Strength of PMMA Bone Cement Loaded With Borate Bioactive Glass

Funk

Burkes

Cole

et al. 2018

J. Bone Joint Infect.

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Introduction: Local delivery of antibiotics using bone cement as the delivery vehicle is an established method of managing implant-associated orthopedic infections. Various fillers have been added to cement to increase antibiotic elution, but they often do so at the expense of strength. This study evaluated the effect of adding a borate bioactive glass, previously shown to promote bone formation, on vancomycin elution from PMMA bone cement.Methods: Five cement composites were made: three loaded with borate bioactive glass along with 0, 1, and 5 grams of vancomycin and two without any glass but with 1 and 5 grams vancomycin to serve as controls. The specimens were soaked in PBS. Eluate of vancomycin was collected every 24 hours and analyzed by HPLC. Orthopedic-relevant mechanical properties of each composite were tested over time.Results: The addition of borate bioactive glass provided an increase in vancomycin release at Day 1 and an increase in sustained vancomycin release throughout the treatment period. An 87.6% and 21.1% increase in cumulative vancomycin release was seen for both 1g and 5g loading groups, respectively. Compressive strength of all composites remained above the weight-bearing threshold of 70 MPa throughout the duration of the study with the glass-containing composites showing comparable strength to their respective controls.Conclusion: The incorporation of borate bioactive glass into commercial PMMA bone cement can significantly increase the elution of vancomycin. The mechanical strength of the cement-glass composites remained above 70 MPa even after soaking for 8 weeks, suggesting their suitability for orthopedic weight-bearing applications.

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Mesoporous silica-based bioactive glasses for antibiotic-free antibacterial applications

Cited by 150 publications

References 120 publications

Effect of titanium implants with coatings of different pore sizes on adhesion and osteogenic differentiation of BMSCs

Effect of titanium implants with coatings of different pore sizes on adhesion and osteogenic differentiation of BMSCs

Synthesis and Characterization of Silver-Doped Mesoporous Bioactive Glass and Its Applications in Conjunction with Electrospinning

Antibiotic Elution and Mechanical Strength of PMMA Bone Cement Loaded With Borate Bioactive Glass

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