Mesoporous SBA-15 molecular sieve as a carrier for controlled release of nimodipine

Yu, Hui; Zhai, Qing-Zhou

doi:10.1016/j.micromeso.2009.04.013

Cited by 84 publications

(32 citation statements)

References 41 publications

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“…The synthesized SBA-15, in this research, indicates a rope-like morphology with the relative length of~1 μm as shown in Fig TEM images of SBA-15, SBA-15-NH 2 and drug loaded particles that are illustrated in Fig. 2(d-f) revealed direct evidence that the materials are well ordered hexagonal arrays of mesopores (1D channel) and 2D hexagonal structure [23]. The modification does not change the original inorganic wall structure of the parent SBA-15 silica (Fig.…”

Section: Sem and Tem Imagessupporting

confidence: 53%

Functionalized silica nanoparticles as a carrier for Betamethasone Sodium Phosphate: Drug release study and statistical optimization of drug loading by response surface method

Ghasemnejad

Ahmadi

Mohamadnia

et al. 2015

Materials Science and Engineering: C

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Section: Sem and Tem Imagessupporting

confidence: 53%

Functionalized silica nanoparticles as a carrier for Betamethasone Sodium Phosphate: Drug release study and statistical optimization of drug loading by response surface method

Ghasemnejad

Ahmadi

Mohamadnia

et al. 2015

Materials Science and Engineering: C

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“…TEM images of SBA-15 at a parallel orientation ( Figure 2A) and at a vertical orientation ( Figure 2B) clearly show well ordered hexagonal arrays of mesopores and straight lattice fringes viewed along and perpendicular to the pore axis, confirming the existence of a two-dimensional hexagonal structure of p6mm symmetry. 30 The mean pore size was approximately 6.5 nm when measured by analySIS 5.0 software.…”

Section: Resultsmentioning

confidence: 98%

Increasing the oral bioavailability of poorly water-soluble carbamazepine using immediate-release pellets supported on SBA-15 mesoporous silica

Wang¹,

Bao²,

Quan³

et al. 2012

IJN

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Background and methods:The aim of this study was to develop an immediate-release pellet formulation with improved drug dissolution and adsorption. Carbamazepine, a poorly watersoluble drug, was adsorbed into mesoporous silica (SBA-15-CBZ) via a wetness impregnation method and then processed by extrusion/spheronization into pellets. Physicochemical characterization of the preparation was carried out by scanning electron microscopy, transmission electron microscopy, nitrogen adsorption, small-angle and wide-angle x-ray diffraction, and differential scanning calorimetry. Flowability and wettability of the drug-loaded silica powder were evaluated by bulk and tapped density and by the angle of repose and contact angle, respectively. The drug-loaded silica powder was formulated into pellets to improve flowability. Results: With maximum drug loading in SBA-15 matrices determined to be 20% wt, in vitro release studies demonstrated that the carbamazepine dissolution rate was notably improved from both the SBA-15 powder and the corresponding pellets as compared with the bulk drug. Correspondingly, the oral bioavailability of SBA-15-CBZ pellets was increased considerably by 1.57-fold in dogs (P , 0.05) compared with fast-release commercial carbamazepine tablets. Conclusion: Immediate-release carbamazepine pellets prepared from drug-loaded silica provide a feasible approach for development of a rapidly acting oral formulation for this poorly water-soluble drug and with better absorption.

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“…As follows from hitherto studies, one of the most often used pharmaceutical carriers is porous silica [34]. Although not much attention has been paid to the systems with NM, some attempts at using the hexagonally ordered mesoporous material SBA-15 [35] and macroporous silica spheres PMS [36] confirmed that these materials have beneficial effect on the release rate of NM.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous drug carrier systems for enhanced delivery rate of poorly water-soluble drug: nimodipine

et al. 2015

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Two mesoporous silica materials: MCM-41 and SBA-15 were applied as potential nanocarriers for poorly soluble drug-nimodipine. Drug incorporation was performed using modified adsorption from the solution method and loaded samples before and after washing procedure were studied. The physical properties were verified by: differential scanning calorimetry, X-ray powder diffraction, electron microscopies (SEM/TEM) and Fourier-transform infrared spectroscopy (FT-IR). FT-IR results for bulk nimodipine were interpreted on the basis of first principles calculations (DFT). As a result of encapsulation process, in both matrices nimodipine appeared simultaneously in two forms: crystalline and amorphous, but the first one turned out to be easily removable during washing procedure. The in vitro dissolution and release tests were performed with ultra pure water under supersaturating conditions. The release rate of the amorphous nimodipine from mesoporous silica materials was at least 70 times higher than dissolution rate of bulk drug, thus revealed a potential usefulness of such carrier in future pharmaceutical applications in terms of delivery of poorly soluble drugs.

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Mesoporous SBA-15 molecular sieve as a carrier for controlled release of nimodipine

Cited by 84 publications

References 41 publications

Functionalized silica nanoparticles as a carrier for Betamethasone Sodium Phosphate: Drug release study and statistical optimization of drug loading by response surface method

Functionalized silica nanoparticles as a carrier for Betamethasone Sodium Phosphate: Drug release study and statistical optimization of drug loading by response surface method

Increasing the oral bioavailability of poorly water-soluble carbamazepine using immediate-release pellets supported on SBA-15 mesoporous silica

Mesoporous drug carrier systems for enhanced delivery rate of poorly water-soluble drug: nimodipine

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