Functionalized silica nanoparticles as a carrier for Betamethasone Sodium Phosphate: Drug release study and statistical optimization of drug loading by response surface method

The Relevance of Point Defects in Studying Silica-Based Materials from Bulk to Nanosystems

“…In these cases, the generation of SiOH groups, through the breaking of strained bonds [45,50] and the reduction of the NBOHC [6,[51][52][53] content, can be the reason for the observed modifications [44,45,47,48], transforming their presence into an advantage. Furthermore, the same SiOH groups are crucial for the functionalization of the surface of silica nanoparticles, paving the way for several applications [13,28,29].…”

“…On the other hand, the chemical production of silica nanoparticles is an efficient way to have SiOH with the resulting advantage for functionalization. Regarding nanoparticles, it is important to note that surface functionalization can be combined with the insertion of small or large molecules that can emit light or have other functions [13][14][15]29,33].…”

“…While the study of the radiation response of a device containing silica is strictly related to the defects, these defects can be relevant also when irradiation is not present. A clear example of this is constituted by the Si-OH defects for telecommunication fibers [27] and nanoparticles [13,28,29]. [1,2]; (b) Scheme of a silicon-on-insulator (SOI) according to that reported in [2]; (c) Optical fiber basic representation with core and cladding; (d) Scheme of a silica nanoparticle with some of the characteristics obtained in [30][31][32][33][34][35][36][37][38][39][40][41].…”

Synthesis of Molecularly Imprinted Polymers (Mips) Used for Estimation of Betamethasone Disodium Phosphate (Bmsp) Using Different Functional Monomers

“…1, its is Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride, Natural and synthetic glucocorticoids are known to be highly effective drugs for the treatment of inflammatory diseases. They are widely administrated to relieve joint pain,symptoms of inflammatory skin problems and inflammation due to arthritis, asthma and rhinitis in clinical , It is active in replacement therapy for adrenal insufficiency and as an anti-inflammatory and immunosuppressant, inflammatory bowel disease, reactive airways disease, and respiratory distress syndrome in preterm infants and pruritus in corticosteroidresponsive dermatoses, ulcerative colitis, lupus erythematosus, acute leukemia (14,18), BMSP was estimated in several ways, including the use of UPLC / MS / MS (6,11) , and was estimated using a voltammetric method (19), and the use of prepared and modified silica compounds (13), Methods were also developed using (RP-HPLC) (12,13), this study was formulation and evaluation of betamethasone sodium phosphate (BMSP) loaded chitosan nanoparticle(CNPs) using cross-linked chitosan malic acid derivative for better therapeutic effect. The prepared BMSP loaded CNPs (16) , A chiral biosensing platform was developed using (BMSP) as chiral recognition element through multilayered electrochemical deposition of BMSP, overoxidized polypyrrole, and nanosheets of graphene (OPPy-BMSP /GR), for enantio-recognition of mandelic acid (MA) enantiomers (9), Were Estimated (BMSP) using Novel magnetic molecularly imprinted polymer nanoparticles (MMIPs) using methacrylic acid as a functional monomer, MAEMA as a cross-linker, and betamethasone as a template The Fe3O4 nanoparticles were encapsulated with a SiO2 shell and functionalized with ACH@CH2 and MMIPs(7), were as Estimated (BMSP) using Novel magnetic molecularly imprinted polymer nanoparticles (MMIPs) using BY precipitation polymerization were prepared MMIPs were prepared by using methacrylic acid as a functional monomer, N,N-pphenylene bismethacryl amide as a crosslinking agent and betamethasone as template (8) of standard Betamethasone Sodium Phosphate in the methanol and completed to(100 mL) in the volumetric flask .The other solutions were prepared in100 mL at the ranged from (10-100 µg.ml -1 ) in the same procedure.…”

Response of Fibroblasts MRC-5 to Flufenamic Acid-Grafted MCM-41 Nanoparticles

“…Another experiment done in vivo, in nude mice with labelled silica nanoparticles and assessed by ultrasound, showed low cytotoxicity; in three days, the silica started to degrade from inside out in an in vitro test [25]. Functionalization of silica nanoparticles with 3-Aminopropyltriethoxysilane (APTES) for surface amination, using the silanol groups as anchoring sites, have been reported by various groups, followed by further grafting with anti-cancer drugs or tumor-directing agents [26,27]. Although some drugs are already available in nanocarriers, such as liposomes and silica, FFA is not available in any type of nanoparticle employed for clinical use.…”