Mesoporous Mg-doped hydroxyapatite nanorods prepared from bio-waste blue mussel shells for implant applications

Karunakaran, Gopalu; Cho, Eun‐Bum; Kumar, G. Suresh; Kolesnikov, Еvgeny; Janarthanan, Gopinathan; Pillai, Mamatha M.; Selvakumar, R.; Boobalan, Selvakumar; Sudha, Kattakgoundar Govindaraj; Rajeshkumar, Mohan Prasanna

doi:10.1016/j.ceramint.2020.08.009

Cited by 29 publications

(15 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This data shows that the doping with Zr forms solid solutions and supports the XRD data which shows that Zr can be well accommodated in the HAp crystal lattice. The dopant ion accom-modated in the HAp crystal can reduce the band intensity and broaden the band as reported by Anushika et al [18] who synthesized Ti-doped HAp, Perez et al [22] who synthesized Si-doped HAp, Mondal et al [23] who synthesized Er-doped HAp, and Karunakaran et al [31] who synthesized Mg-doped HAp. In this study, the reduction in band intensity also occurred due to Zrdoping.…”

Section: Ftir Analysesmentioning

confidence: 91%

Hydrothermally synthesis and characterization of HAp and Zr-doped HAp nanoparticles from bovine bone and zircon for photodynamic therapy

Gustaman

Hadi

Kurniawan

et al. 2021

PAC

View full text Add to dashboard Cite

HAp and Zr-doped HAp nanoparticles were synthesized from bovine bone and local zircon material by using the hydrothermal method. XRD analysis showed that the HAp and Zr-doped HAp nanoparticles had hexagonal structure with a crystallite size of 20-36 nm and the lattice constants a = 9.8-9.9? and c = 6.5-6.8 ?. XRD data also showed that up to 20 at.% of Zr can be accommodated in HAp crystal structure. The lattice constant and cell volume decreased with increasing Zr concentration. FTIR data confirmed that the majority of functional groups that exist on the surface of the HAp and Zr-doped HAp nanoparticles were the hydroxyl and phosphate groups. Suspensions with the HAp and Zr-doped HAp nanoparticles prepared using citric acid as dispersant were stable with zeta potential between ?31 and ?35mV at pH = 7. Reactive oxygen species are generated on the produced HAp and Zr-doped Hap nanoparticles and confirm their potential for application in photodynamic therapy.

show abstract

Section: Ftir Analysesmentioning

confidence: 91%

Hydrothermally synthesis and characterization of HAp and Zr-doped HAp nanoparticles from bovine bone and zircon for photodynamic therapy

Gustaman

Hadi

Kurniawan

et al. 2021

PAC

View full text Add to dashboard Cite

show abstract

“…The microwave-assisted synthesis method was applied to obtain various sizes and complex mesoporous morphologies that can be subsequently applied in implantation. Also, the presence of PVP improved the microwave-stimulated approach, which effectively regulated pore volume, surface area, size, and dimensions by regulating the formation of HA crystals [ 130 ].…”

Section: Ha-based On Natural Sources Used In Btementioning

confidence: 99%

Novel Trends into the Development of Natural Hydroxyapatite-Based Polymeric Composites for Bone Tissue Engineering

et al. 2022

View full text Add to dashboard Cite

In recent years, the number of people needing bone replacements for the treatment of defects caused by chronic diseases or accidents has continuously increased. To solve these problems, tissue engineering has gained significant attention in the biomedical field, by focusing on the development of suitable materials that improve osseointegration and biologic activity. In this direction, the development of an ideal material that provides good osseointegration, increased antimicrobial activity and preserves good mechanical properties has been the main challenge. Currently, bone tissue engineering focuses on the development of materials with tailorable properties, by combining polymers and ceramics to meet the necessary complex requirements. This study presents the main polymers applied in tissue engineering, considering their advantages and drawbacks. Considering the potential disadvantages of polymers, improving the applicability of the material and the combination with a ceramic material is the optimum pathway to increase the mechanical stability and mineralization process. Thus, ceramic materials obtained from natural sources (e.g., hydroxyapatite) are preferred to improve bioactivity, due to their similarity to the native hydroxyapatite found in the composition of human bone.

show abstract

“…It helps to maintain a stable and strong heart rate, ensures muscle contraction and expansion, reduces the risk of osteoporotic bone, and accelerates the process of natural bone regeneration [30][31][32]. Mg deficiency negatively affects all stages of skeletal metabolism causing the cessation of bone growth, decreased activity of osteoblasts and osteoclasts, as well as osteopenia and bone fragility [32][33][34][35].…”

Section: Advanced Nanomaterialsmentioning

confidence: 99%

Advanced Nanomaterials and Coated Surfaces for Orthopedic Implants – A Review

Balint¹,

Mocanu²,

Tomoaia³

et al. 2021

AnnalsARSciPhysChem

View full text Add to dashboard Cite

Critical-sized defects in bone induced by trauma have in numerous presented cases difficult challenges to the current treatment for bone repair. The main purpose of bone tissue engineered scaffolds is to use advanced materials to promote the natural healing process of bone which does not easily occur in critical-sized defects or on metallic implants. A synthetic bone scaffold and a coating on Ti implants must be biocompatible and biodegradable to allow the native tissue integration, and mimic the chemical composition and structure of native bone. In addition to being physically and chemically biomimetic, an ideal scaffold and the coating layers on metallic implants must be capable of releasing essential physiologic elements, like Mg, Zn, Sr and Si, and also containing bioactive molecules (e.g., collagen, COL) to accelerate extracellular matrix production and tissue integration. Also, these advanced materials might be doped with drugs (e.g., antibiotics, such as vancomycin) to prevent undesired biological response such as infections, especially with Staphylococcus aureus, S. aureus. Various biomaterials include hydroxyapatite (HAP) ceramics or multifunctional hydroxyapatite substituted with Mg, Zn, Sr and Si, mf-HAP, polymers, such as poly lactic acid (PLA, approved for medical applications by Food and Drug Administration, US FDA, and collagen, or their mixtures as biomimetic composites which have been investigated for their potential as bone scaffold materials and coatings on metallic implants. This article briefly reviews the physical and chemical characteristics of used advanced materials and describes the key-technologies in mimicking the physical and chemical environment of bone using synthetic materials, and provides an over view of local drug delivery as it pertains to bone tissue engineering.

show abstract

Mesoporous Mg-doped hydroxyapatite nanorods prepared from bio-waste blue mussel shells for implant applications

Cited by 29 publications

References 68 publications

Hydrothermally synthesis and characterization of HAp and Zr-doped HAp nanoparticles from bovine bone and zircon for photodynamic therapy

Hydrothermally synthesis and characterization of HAp and Zr-doped HAp nanoparticles from bovine bone and zircon for photodynamic therapy

Novel Trends into the Development of Natural Hydroxyapatite-Based Polymeric Composites for Bone Tissue Engineering

Advanced Nanomaterials and Coated Surfaces for Orthopedic Implants – A Review

Contact Info

Product

Resources

About