Mesoporous magnesium silicate-incorporated poly(ε-caprolactone)-poly(ethylene glycol)- poly(ε-caprolactone) bioactive composite beneficial to osteoblast behaviors

Abstract

Mesoporous magnesium silicate (m-MS) and poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL) composite (m-MPC) was synthesized by solvent casting method. The results suggest that the mechanical properties of compressive strength and elastic modulus, as well as hydrophilicity, of the m-MPC increased with increase of m-MS content in the composites. In addition, the weight loss of the m-MPC improved significantly with the increase of m-MS content during composite soaking in phosphate-buffered saline for 10 weeks, indicating that incorporation of m-MS into PCL-PEG-PCL could enhance the degradability of the m-MPC. Moreover, the m-MPC with 40 w% m-MS could induce a dense and continuous apatite layer on its surface after soaking in simulated body fluid for 5 days, which was better than m-MPC 20 w% m-MS, exhibiting excellent in vitro bioactivity. In cell cultural experiments, the results showed that the attachment and viability ratio of MG63 cells on m-MPC increased significantly with the increase of m-MS content, showing that the addition of m-MS into PCL-PEG-PCL could promote cell attachment and proliferation. The results suggest that the incorporation of m-MS into PCL-PEG-PCL could produce bioactive composites with improved hydrophilicity, degradability, bioactivity, and cytocompatibility.

Stimuli-Responsive Codelivery System-Embedded Polymeric Nanofibers with Synergistic Effects of Growth Factors and Low-Intensity Pulsed Ultrasound to Enhance Osteogenesis Properties

“…The presence of hydroxyl groups on the surface of DSTNs promotes interactions with water molecules, reducing the surface tension and making the nanofibers more prone to wetting, resulting in a lower WCA. 58 We also investigated surface functional groups and chemical interactions within the nanocomposite using FTIR spectroscopy, and the resulting FTIR spectra for various samples are depicted in Figure 3. In the FTIR spectrum of DSTNs, distinct peaks were identified at 463, 804, and 1100 cm −1 , signifying the bending, symmetric stretching, and asymmetric stretching vibrations of Si−O−Si bonds, respectively.…”

“…This phenomenon is attributed to the inherent hydrophilic nature of silica-based materials. The presence of hydroxyl groups on the surface of DSTNs promotes interactions with water molecules, reducing the surface tension and making the nanofibers more prone to wetting, resulting in a lower WCA …”

Quantifying the degradation of degradable implants and bone formation in the femoral condyle using micro‑CT 3D reconstruction

“…There has been much research on degradable implants for applications in orthopedics ( 31 – 34 ), such as those made of polylactic-co-glycolic acid and magnesium alloys. It has been reported that the degradation of implant material and formation of new bone, and notably, the balance between these two processes, are important evaluation indices ( 35 ). Traditional methods of assessing degradation have unavoidable disadvantages, and the evaluation of new bone formation generally relies on images obtained from histology and radiography, which are imprecise and difficult to analyze quantitatively ( 36 , 37 ).…”

Clinoptilolite/PCL–PEG–PCL composite scaffolds for bone tissue engineering applications

“…[18][19][20] In recent years, PEG was approved by U.S. Food and Drug Administration (FDA) for internal use in biomedical research and applications. 21 It has been used in bone tissue constructs for increasing hydrophilicity and degradability of the scaffolds [22][23][24] as well as to improve cellular attachment, guidance, and biocompatibility. [25][26][27] Various block copolymers of PEG with PCL have been used for different biomedical applications.…”