Mesoporous carbon nanomaterials in drug delivery and biomedical application

Zhao, Qinfu; Lin, Yuanzhe; Han, Ning; Li, Xian; Geng, Hongjian; Wang, Xiudan; Cui, Yu; Wang, Siling

doi:10.1080/10717544.2017.1399300

Cited by 142 publications

(68 citation statements)

References 125 publications

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“…To date, the highly ordered mesoporous carbon (OMC) is played a crucial role for developing metal‐air battery, fuel cells, supercapacitor, solar cell, hydrogen storage, drug delivery, and sensor devices . The main reason is that the ordered mesoporous carbon derived from the KIT‐6 silica yielded higher surface area (>1000 m 2 /g), uniform pore structure, large pore size (20 to 100Å), pore volume (>0.6 cm 3 /g), and good reproducibility.…”

Section: Introductionmentioning

confidence: 99%

KIT‐6 Three Dimensional Template Derived Mesoporous Carbon for Oxygen Reduction Reaction: Effect of Template Removal on Catalytic Activity

et al. 2018

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Non precious highly ordered mesoporous carbon (OMC) is of indomitable and perennial catalyst in fuel cells owing to their unique traits and abundant sources. The OMC has been synthesized using KIT-6 sacrificial template and then this removed by three different etching agents, viz, hydrofluoric acid (HF), sodium hydroxide (NaOH) and polyvinylidene fluoride (PVDF). The principle aim of the present work is that to inspect the etched OMCs for oxygen reduction reaction (ORR) activity. In order to understand the effect of etching, we have first studied their fundamental properties. Among three, the HF etched OMC possess comparative surface area (234 m 2 g -1 ), mesoporous sizes (6 nm), large pore volumes (0.13 cm 3 g -1 ) and more accessible defective active sites (I D /I G = 0.90). Hence, the HF etched OMC replica manifest better ORR activity than others in terms of having (0.83 V) onset and (0.71 V) half wave potential, and (2.6 mA/cm 2 at 0.2 V) current density in potassium hydroxide (KOH) electrolyte. From the Nyquist plot, a small semicircle (R ct = 13 Ω cm -2 ) of HF etched OMC substantiates its better ORR activity. A comparative study on etching of OMC using different etching agents could guide to find out a suitable etching agent for modifying the surface properties of OMC.

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Section: Introductionmentioning

confidence: 99%

KIT‐6 Three Dimensional Template Derived Mesoporous Carbon for Oxygen Reduction Reaction: Effect of Template Removal on Catalytic Activity

et al. 2018

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“…Indeed, ordered mesoporous carbon materials, although rarely considered so far in the biomedical sector, are receiving increasing interest for several applications, from controlled delivery and release of therapeutic agents, to bio-imaging, bioadsorption and bio-sensing, thanks to their multiple promising properties combining the advantages of the mesoporous nanostructure and carbonaceous composition: presence of an organized mesoporous network with large surface area, high pore volume and tunable pore size, high chemical and mechanical stability, high biocompatibility, ease of surface modification and ability to act as high-absorbing inert agents. 16,17 All these properties make ordered mesoporous carbons an attractive versatile system that may be employed in the treatment of pathological conditions, which require a local-sustained therapeutic agent release and the payload can be carried out with several different therapeutic agents (e.g. drugs, ions, biological molecules, nanoparticles).…”

Section: Introductionmentioning

confidence: 99%

<p>Silver Decorated Mesoporous Carbons for the Treatment of Acute and Chronic Wounds, in a Tissue Regeneration Context</p>

Torre¹,

Giasafaki²,

Steriotis³

et al. 2019

IJN

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Introduction: Silver decorated mesoporous carbons are interesting systems that may offer effective solutions for advanced wound care products by combining the well-known antimicrobial activity of silver nanoparticles with the versatile properties of ordered mesoporous carbons. Silver is being used as a topical antimicrobial agent, especially in wound repair. However, while silver shows bactericidal properties, it is also cytotoxic at high concentrations. Therefore, the incorporation of silver into ordered mesoporous carbons allows to exploit both silver's biological effects and mesoporous carbons' biocompatibility and versatility with the purpose of conceiving silver-doped materials in light of the growing health concern in wound care. Methods: The wound healing potential of an ordered mesoporous carbon also doped with two different loadings of silver nanoparticles (2 wt% and 10 wt%), was investigated through a biological assessment study based on different assays (cell viability, inflammation, antibacterial tests, macrophage-conditioned fibroblast and human keratinocyte cell cultures). Results: The results show silver-doped ordered mesoporous carbons to positively condition cell viability, with a cell viability percentage >70% even for 10 wt% Ag, to modulate the expression of inflammatory cytokines and of genes involved in tissue repair (KRT6a, VEGFA, IVN) and remodeling (MMP9, TIMP3) in different cell systems. Furthermore, along with the biocompatibility and the bioactivity, the silver-doped ordered mesoporous carbons still retain an antibacterial effect, as shown by a maximum of 13.1% of inhibited area in the Halo test. The obtained results clearly showed that the silver-doped ordered mesoporous carbons exhibit both good biocompatibility and antibacterial effect with enhanced re-epithelialization, angiogenesis promotion and tissue regeneration. Discussion: These findings suggest that the exceptional properties of silver-doped ordered mesoporous carbons could be exploited in the treatment of acute and chronic wounds and that such carbon materials could be potential candidates for use in medical devices for wound healing purposes, in particular, the 10 wt% loading, as the results showed to be the most effective.

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“…As mentioned earlier mesoporous carbon nanocarriers give the engineering freedom to manipulate its features in order to accommodate its role. Features such as porosity 36, , shape 36 and size 76 have been altered by controlling the synthesis process to acquire desired benefits. However, no reports have been published so far (to best of our knowledge) regarding the influence of carbonisation temperature on mesoporous carbon nanocarriers in biomedical application.…”

Section: Synthesis Of Mesoporous Carbon Nanospheresmentioning

confidence: 99%

“…As far as carbon-based nanocarrier systems are concerned, they are no exception to the factors mentioned above and they do influence them to a certain extent. The application performance of mesoporous carbon nanospheres is strongly influenced by numerous factors such as surface modification, particle, pore size, reaction time and reaction temperature 36,75,81,82 . Optimization of such factors helps it to attain desirable properties such as higher stability, loading capacity, better bioavailability, better encapsulation, controlled drug release, the possibility of incorporation of both hydrophilic and hydrophobic substances, the feasibility of variable routes of administration, which are vital features for carbon nanocarrier systems to consider as efficient drug delivery systems.…”

Section: Parameters For Optimisation Of the Physicochemical Propertiementioning

confidence: 99%

“…133,[137][138][139] ; but also showed promising performance in recovery and restoration in patients who suffered traumatic brain injury 12 . However, among the various carbon particles utilized for biomedical applications, mesoporous carbon nanomaterials hold a more significant promise as it has a carbonaceous composition with high porosity, biocompatibility, chemical inertness, cellular affinity, which are highly desirable traits for therapeutics strategies 2,36 . Moreover, owing to its physicochemical properties, biocompatibility and its cellular affinity, it readily interacts with ROS species (hydroxyl radicals) in the cells and displays ROS scavenging activity, which has never been reported in any other carbon nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

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Optimised multifunctionality of mesoporous carbon hollow spheres (MCHS) nanocarriers using carbonisation temperature

Ghosh¹

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Currently, chemotherapeutic research is using smart and specially engineered multifunctional nanocarriers for targeted nanomedicine for improved and promising cancer treatment. Mesoporous carbon nanomaterials (MCNs) have been widely regarded for this purpose owing to its multifunctional nature. MCNs possess unique combinations of chemical and physical properties along with high surface area, high porosity, biocompatibility and high cellular uptake making them up-and-coming candidates in many areas of biomedical research such as drug delivery, tissue scaffolding, cellular sensors, etc. With a steady increment in the biomedical research centred on MCN as potential nanocarrier systems for chemotherapeutics, the need to determine the optimised conditions to synthesise MCN with the most desirable traits are that much more necessary. One of the critical factors that control the physical, chemical, electrical and mechanical behaviour of MCN is the carbonisation temperature. Carbonisation temperature determines the carbon content, carbon bonding, crystallinity, hydrophobicity, solubility, porosity which in turn influences their effectiveness. Although there have been studies on the characteristic differences in MCNs influenced by carbonisation temperature, however, the impact the carbonisation temperature makes in bio-application of MCN has not been reported so far. So, this PhD aims to study the influence of carbonisation temperature in MCNs and to investigate its behaviour in the biological environment for varied biological applications. In the first part, we prepared mesoporous carbon hollow spheres (MCHS) using resorcinol-formaldehyde polymer and silica hard-template in the one-pot synthesis process. We carbonised the polymer-silica matrix at different carbonisation temperatures (MCHS-T) and studied its changes in physical and chemical properties such as morphology, aqueous distribution, crystallinity, hydrophobicity, carbon content, surface area and porosity. We further investigated the loading capacity and release pattern of the various carbonised samples and their intracellular behaviour. We observed that the delivery of therapeutic biomolecule in cancer cells varied depending on which temperature the nanocarriers were carbonised which led to different cytotoxicity. With this study, we were able to find out the optimised temperature at which mesoporous carbon hollow spheres should be carbonised to achieve the best nanocarrier performance for the delivery of therapeutic protein in cancer therapy. In the second part, we investigated the antioxidant property (free radical scavenging) mediated by the temperature of carbonisation of MCHS-T. We found that MCHS-T is a great antioxidant agent which lowers the ROS levels in cells that are suffering from oxidative stress. We carbonised MCHS-T from temperatures 700-1300˚ C to find the optimised

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Mesoporous carbon nanomaterials in drug delivery and biomedical application

Cited by 142 publications

References 125 publications

KIT‐6 Three Dimensional Template Derived Mesoporous Carbon for Oxygen Reduction Reaction: Effect of Template Removal on Catalytic Activity

KIT‐6 Three Dimensional Template Derived Mesoporous Carbon for Oxygen Reduction Reaction: Effect of Template Removal on Catalytic Activity

<p>Silver Decorated Mesoporous Carbons for the Treatment of Acute and Chronic Wounds, in a Tissue Regeneration Context</p>

Optimised multifunctionality of mesoporous carbon hollow spheres (MCHS) nanocarriers using carbonisation temperature

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