Mesoporous bioactive glasses: Promising platforms for antibacterial strategies

Processing methods for making porous bioactive glass‐based scaffolds—A state‐of‐the‐art review

“…19 3. 10,[23][24][25][26] Combining different kinds of materials is a valuable strategy to obtain new materials with enhanced properties, resulting from the characteristics of the starting raw materials. 22 In addition to the former oxides and basic modifiers (eg, CaO, Na 2 O), a lot of other metallic doping elements can be added to the composition to tune the bioactivity and give peculiar extra-functionalities to the glasses, such as silver (antibacterial effect), copper (angiogenesis), and strontium (anti-osteoporotic effect).…”

“…22 In addition to the former oxides and basic modifiers (eg, CaO, Na 2 O), a lot of other metallic doping elements can be added to the composition to tune the bioactivity and give peculiar extra-functionalities to the glasses, such as silver (antibacterial effect), copper (angiogenesis), and strontium (anti-osteoporotic effect). 10,[23][24][25][26] Combining different kinds of materials is a valuable strategy to obtain new materials with enhanced properties, resulting from the characteristics of the starting raw materials. Thus, it is possible to finely design and improve the physico-chemical and mechanical properties of the final scaffold by merging polymers and bioactive glasses.…”

Multifunctional Copper-Containing Mesoporous Glass Nanoparticles as Antibacterial and Proangiogenic Agents for Chronic Wounds

“…Among the wide class of advanced biomaterials, mesoporous bioactive glasses (MBGs) have attracted increasing attention to develop alternative and promising antibacterial strategies, primarily because of their capability to release therapeutic dosages of antimicrobial agents (Kargozar et al, 2018), thanks to the excellent exposed surface area and accessible uniform nanochannels (Vallet-Regí, 2010). More recently, several studies proved that the incorporation of selected therapeutic ions into the MBG framework imparts specific biological functions, such as antibacterial, proosteogenic and proangiogenic effects (Hoppe et al, 2011;Wu and Chang, 2014).…”

3D Printing of Hierarchical Scaffolds Based on Mesoporous Bioactive Glasses (MBGs)—Fundamentals and Applications

“…organic (drugs, growth factors) or inorganic therapeutic agents (metallic ions) [32][33][34][35]. The impressive versatility of these systems allowed scientists to design them, for example, as multipurpose biomaterials for improving bone healing, eliciting antiseptic action by introducing specific cations into the MBG structure (e.g., Ag + , Zn 2+ , Cu 2+ , Ga 2+ , Ce 3+ and Ce 4+ ) [36][37][38] or even targeting to tumor therapy [39]. In this regard, it has been demonstrated that including small amounts of Fe2O3 in MBGs is sufficient to induce a magnetic response of the material after exposure to an external magnetic field, which results in a localized production of heat [40]-this effect can lead to the selective death of cancer cells by hyperthermia [39].…”

“…Incorporation of additional oxides in the composition (e.g., CaO and P 2 O 5 ) allowed obtaining mesoporous bioactive glasses (MBGs) [29][30][31], which are potentially able to provide multiple therapeutic actions by supporting bone tissue ingrowth and regeneration while simultaneously providing a local treatment of diseased bone through the controlled release of organic (drugs, growth Materials 2020(drugs, growth Materials , 13, 1688 3 of 19 factors) or inorganic therapeutic agents (metallic ions) [32][33][34][35]. The impressive versatility of these systems allowed scientists to design them, for example, as multipurpose biomaterials for improving bone healing, eliciting antiseptic action by introducing specific cations into the MBG structure (e.g., Ag + , Zn 2+ , Cu 2+ , Ga 2+ , Ce 3+ and Ce 4+ ) [36][37][38] or even targeting to tumor therapy [39]. In this regard, it has been demonstrated that including small amounts of Fe 2 O 3 in MBGs is sufficient to induce a magnetic response of the material after exposure to an external magnetic field, which results in a localized production of heat [40]-this effect can lead to the selective death of cancer cells by hyperthermia [39].The production of MBGs relies upon sol-gel synthesis combined with supramolecular chemistry [41].…”