Multifunctional Copper-Containing Mesoporous Glass Nanoparticles as Antibacterial and Proangiogenic Agents for Chronic Wounds

Paterson, Thomas; Bari, Alessandra; Bullock, Anthony J.; Turner, Robert D.; Montalbano, Giorgia; Fiorilli, Sonia Lucia; Vitale-Brovarone, C.; MacNeil, Sheila; Shepherd, Joanna

doi:10.3389/fbioe.2020.00246

Cited by 36 publications

(37 citation statements)

References 44 publications

(44 reference statements)

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“…This is significant, as S. aureus is among the most common pathogens found in bone infections [1,2]. Recent studies have shown that treating the motile S. aureus in an infected 3D tissue model is more challenging than treating a monolayer bacteria assay [38]. Therefore, this would be the logical progression for the testing of this material.…”

Section: Discussionmentioning

confidence: 99%

Electrospun Scaffolds Containing Silver-Doped Hydroxyapatite with Antimicrobial Properties for Applications in Orthopedic and Dental Bone Surgery

Paterson

Shi

Tian

et al. 2020

JFB

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Preventing the development of osteomyelitis while enhancing bone regeneration is challenging, with relatively little progress to date in translating promising technologies to the clinic. Nanoscale hydroxyapatite (nHA) has been employed as a bone graft substitute, and recent work has shown that it may be modified with silver to introduce antimicrobial activity against known pathogens. The aim of this study was to incorporate silver-doped nHA into electrospun scaffolds for applications in bone repair. Silver-doped nHA was produced using a modified, rapid mixing, wet precipitation method at 2, 5, 10 mol.% silver. The silver-doped nHA was added at 20 wt.% to a polycaprolactone solution for electrospinning. Bacteria studies demonstrated reduced bacterial presence, with Escherichia coli and Staphylococcus aureus undetectable after 96 h of exposure. Mesenchymal stem cells (MSCs) were used to study both toxicity and osteogenicity of the scaffolds using PrestoBlue® and alkaline phosphatase (ALP) assays. Innovative silver nHA scaffolds significantly reduced E. coli and S. aureus bacterial populations while maintaining cytocompatibility with mammalian cells and enhancing the differentiation of MSCs into osteoblasts. It was concluded that silver-doped nHA containing scaffolds have the potential to act as an antimicrobial device while supporting bone tissue healing for applications in orthopedic and dental bone surgery.

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Section: Discussionmentioning

confidence: 99%

Electrospun Scaffolds Containing Silver-Doped Hydroxyapatite with Antimicrobial Properties for Applications in Orthopedic and Dental Bone Surgery

Paterson

Shi

Tian

et al. 2020

JFB

Self Cite

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“…Infection remains one of the most common postoperativce complications to be resolved in all kinds of surgical operations, even in minimally invasive interventional surgery, although modern medicine has advanced aseptic management and developed effective broad-spectrum antibiotics [ [87] , [88] , [89] , [90] , [91] ]. In addition, implant-related infection is a devastating complication following the application of a medical implant.…”

Section: Antibacterial Activity Of Cu-containing Alloysmentioning

confidence: 99%

Biological applications of copper-containing materials

Wang

Yuan

et al. 2021

Bioactive Materials

113

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Copper is an indispensable trace metal element in the human body, which is mainly absorbed in the stomach and small intestine and excreted into the bile. Copper is an important component and catalytic agent of many enzymes and proteins in the body, so it can influence human health through multiple mechanisms. Based on the biological functions and benefits of copper, an increasing number of researchers in the field of biomaterials have focused on developing novel copper-containing biomaterials, which exhibit unique properties in protecting the cardiovascular system, promoting bone fracture healing, and exerting antibacterial effects. Copper can also be used in promoting incisional wounds healing, killing cancer cells, Positron Emission Tomography (PET) imaging, radioimmunological tracing and radiotherapy of cancer. In the present review, the biological functions of copper in the human body are presented, along with an overview of recent progress in our understanding of the biological applications and development of copper-containing materials. Furthermore, this review also provides the prospective on the challenges of those novel biomaterials for future clinical applications.

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“…They could also serve as appropriate platforms for transdermal delivery of a broad range of anticancer agents (e.g., chemicals, drugs, and small interfering RNAs), which may facilitate skin cancer treatment [ 36 , 37 , 38 ]. Incorporating therapeutic ions (e.g., Zn 2+ , Eu 3+ , and Cu 2+ ) into the MSNs has become a highly promising approach for eliciting specific biological responses in damaged sites, including antibacterial, anti-inflammatory, and proangiogenic activities [ 11 , 39 , 40 ].…”

Section: Current Therapies In Managing Wounds and The Potential Of Mesoporous Materialsmentioning

confidence: 99%

“…In another study, Paterson et al [ 40 ] evaluated the angiogenic and antibacterial activities of Cu-doped and undoped silicate MBGs with the compositions of 85SiO 2 /13CaO/2CuO mol% and 85SiO 2 /15CaO (mol%). The prepared samples showed a very high specific surface area (740 m 2 /g) and a uniform pore (size 4 nm) in their structure.…”

Section: Mbgs For Skin Cancer Therapymentioning

confidence: 99%

Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy

et al. 2021

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Exploring new therapies for managing skin wounds is under progress and, in this regard, mesoporous silica nanoparticles (MSNs) and mesoporous bioactive glasses (MBGs) offer great opportunities in treating acute, chronic, and malignant wounds. In general, therapeutic effectiveness of both MSNs and MBGs in different formulations (fine powder, fibers, composites etc.) has been proved over all the four stages of normal wound healing including hemostasis, inflammation, proliferation, and remodeling. The main merits of these porous substances can be summarized as their excellent biocompatibility and the ability of loading and delivering a wide range of both hydrophobic and hydrophilic bioactive molecules and chemicals. In addition, doping with inorganic elements (e.g., Cu, Ga, and Ta) into MSNs and MBGs structure is a feasible and practical approach to prepare customized materials for improved skin regeneration. Nowadays, MSNs and MBGs could be utilized in the concept of targeted therapy of skin malignancies (e.g., melanoma) by grafting of specific ligands. Since potential effects of various parameters including the chemical composition, particle size/morphology, textural properties, and surface chemistry should be comprehensively determined via cellular in vitro and in vivo assays, it seems still too early to draw a conclusion on ultimate efficacy of MSNs and MBGs in skin regeneration. In this regard, there are some concerns over the final fate of MSNs and MBGs in the wound site plus optimal dosages for achieving the best outcomes that deserve careful investigation in the future.

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Multifunctional Copper-Containing Mesoporous Glass Nanoparticles as Antibacterial and Proangiogenic Agents for Chronic Wounds

Cited by 36 publications

References 44 publications

Electrospun Scaffolds Containing Silver-Doped Hydroxyapatite with Antimicrobial Properties for Applications in Orthopedic and Dental Bone Surgery

Electrospun Scaffolds Containing Silver-Doped Hydroxyapatite with Antimicrobial Properties for Applications in Orthopedic and Dental Bone Surgery

Biological applications of copper-containing materials

Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy

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