Mesoporous bioactive glasses for bone healing and biomolecules delivery

Lalzawmliana, V.; Anand, Akrity; Roy, Mousumi; Kundu, Biswanath; Nandi, Samit Kumar

doi:10.1016/j.msec.2019.110180

Cited by 67 publications

(43 citation statements)

References 171 publications

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“…They induced cell adhesion and growth on their porous structure for bone regeneration (Lim et al 2017). Lalzawmliana et al (2019) reported that mesoporous bioactive glass (MGB) scaffolds as third-generation biomaterials were used for regeneration of critical bone defects, and MGB scaffolds should have large interconnected pores for improving growth, adhesion and proliferation of osteoblast cells and assisting in angiogenesis. In recent studies, effect of threedimensional (3D) scaffolds and their fibrous order on biocompatibility were investigated.…”

Section: Scaffolds Combined With Active Biomoleculesmentioning

confidence: 99%

Bone tissue regeneration: biology, strategies and interface studies

2019

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Nowadays, bone diseases and defects as a result of trauma, cancers, infections and degenerative and inflammatory conditions are increasing. Consequently, bone repair and replacement have been developed with improvement of orthopedic technologies and biomaterials of superior properties. This review paper is intended to sum up and discuss the most relevant studies performed in the field of bone biology and bone regeneration approaches. Therefore, the bone tissue regeneration was investigated by synthetic substitutes, scaffolds incorporating active molecules, nanomedicine, cell-based products, biomimetic fibrous and nonfibrous substitutes, biomaterial-based three-dimensional (3D) cell-printing substitutes, bioactive porous polymer/inorganic composites, magnetic field and nano-scaffolds with stem cells and bone-biomaterials interface studies.

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Section: Scaffolds Combined With Active Biomoleculesmentioning

confidence: 99%

Bone tissue regeneration: biology, strategies and interface studies

2019

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“…Due to their highly ordered mesopores and surface area, nanobioglasses can also be excellent delivery vehicles for bioactive molecules (e.g., drugs and proteins) to further boost bone repair (Baino et al, 2017;Wang et al, 2019;Lalzawmliana et al, 2020). For example, Lee J.-H. et al (2017) reported a significant enhancement in osteoblast activity, secretion of ECM molecules and calcification through the controlled release of phenamil (a drug known as a potent BMP signaling activator) and strontium ions from mesoporous bioglass nanoparticles.…”

Section: Nanostructured Bio-glassesmentioning

confidence: 99%

Nanostructured Biomaterials for Bone Regeneration

Lyons

Plantz

Hsu

et al. 2020

Front. Bioeng. Biotechnol.

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This review article addresses the various aspects of nano-biomaterials used in or being pursued for the purpose of promoting bone regeneration. In the last decade, significant growth in the fields of polymer sciences, nanotechnology, and biotechnology has resulted in the development of new nano-biomaterials. These are extensively explored as drug delivery carriers and as implantable devices. At the interface of nanomaterials and biological systems, the organic and synthetic worlds have merged over the past two decades, forming a new scientific field incorporating nano-material design for biological applications. For this field to evolve, there is a need to understand the dynamic forces and molecular components that shape these interactions and influence function, while also considering safety. While there is still much to learn about the bio-physicochemical interactions at the interface, we are at a point where pockets of accumulated knowledge can provide a conceptual framework to guide further exploration and inform future product development. This review is intended as a resource for academics, scientists, and physicians working in the field of orthopedics and bone repair.

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“…Furthermore, it was noted that the VEGF increased in a time-dependent manner over the period of immersion. Recent studies have attempted to load growth factor onto scaffolds so as to enhance wound healing or tissue regeneration [39,40]. According to Li et al, a VEGF-loaded hydroxyapatite-collagen scaffold was able to enhance angiogenesis and osteogenesis in an ischemic limb rat model [31].…”

Section: Vegf Releasementioning

confidence: 99%

Assessment of the Release of Vascular Endothelial Growth Factor from 3D-Printed Poly-ε-Caprolactone/Hydroxyapatite/Calcium Sulfate Scaffold with Enhanced Osteogenic Capacity

Chen

Wang

et al. 2020

Polymers

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Vascular endothelial growth factor (VEGF) is one of the most crucial growth factors and an assistant for the adjustment of bone regeneration. In this study, a 3D scaffold is fabricated using the method of fused deposition modeling. Such a fabricated method allows us to fabricate scaffolds with consistent pore sizes, which could promote cellular ingrowth into scaffolds. Therefore, we drafted a plan to accelerate bone regeneration via VEGF released from the hydroxyapatite/calcium sulfate (HACS) scaffold. Herein, HACS will gradually degrade and provide a suitable environment for cell growth and differentiation. In addition, HACS scaffolds have higher mechanical properties and drug release compared with HA scaffolds. The drug release profile of the VEGF-loaded scaffolds showed that VEGF could be loaded and released in a stable manner. Furthermore, initial results showed that VEGF-loaded scaffolds could significantly enhance the proliferation of human mesenchymal stem cells (hMSCs) and human umbilical vein endothelial cells (HUVEC). In addition, angiogenic- and osteogenic-related proteins were substantially increased in the HACS/VEGF group. Moreover, in vivo results revealed that HACS/VEGF improved the regeneration of the rabbit’s femur bone defect, and VEGF loading improved bone tissue regeneration and remineralization after implantation for 8 weeks. All these results strongly imply that the strategy of VEGF loading onto scaffolds could be a potential candidate for future bone tissue engineering.

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Mesoporous bioactive glasses for bone healing and biomolecules delivery

Cited by 67 publications

References 171 publications

Bone tissue regeneration: biology, strategies and interface studies

Bone tissue regeneration: biology, strategies and interface studies

Nanostructured Biomaterials for Bone Regeneration

Assessment of the Release of Vascular Endothelial Growth Factor from 3D-Printed Poly-ε-Caprolactone/Hydroxyapatite/Calcium Sulfate Scaffold with Enhanced Osteogenic Capacity

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