Mesoblastic Nephroma in Adults: A Clinico-Pathologic Study of Wilms’ Tumors and Related Renal Neoplasms

Wilms' tumor in the adult patient. Diagnosis, management, and review of the world medical literature

“…We concur with Farrow and others who believe that many of the reported cases are not actually Wilms' tumors, but rather renal carcinomas that have characteristic glandular elements and also an abundance of sarcomatous or undifferentiated cells. 8,11,22 Wilms' tumor, whether it occurs in childhood or in adult life, does not contain the mature glandular elements of renal carcinoma but is a mixture of an entirely different cell." A fundamental histologic fact of Wilms' tumors is the presence of abortive or embryonic glomerulatubular structures with an immature spindle cell stroma, which are not found in renal cell c a r~i n o m a .~ In addition, many of the reports of Wilms' tumors in adult patients may be subject to challenge because microscopic confirmation of the diagnosis is lacking.…”

The antigenic structure of nephroblastomas

“…Also the theories that the tumour is of mesonephric origin (Eberth, 1872) or derived from aberrant mesenchyme cells (Wilms, 1899) have been abandoned. It is usually postulated that the tumour originates in the metanephrogenic mesenchyme (Paul, 1886;Muus, 1899;Busse, 1899;Nicholson, 1931 : Culp andHartman, 1948).…”

Morphologie, Histogenese und Klassifikation der Nierentumoren (Part 4 of 4)

“…Nach G r u e n w a l d (102) sind sie von den embryonalen Adenosarkomen kaum zu trennen. C u lp und H a rtm an (49) («mesoblastic nephromas») sowie F r ü h l in g und Blum (83) …”