1999
DOI: 10.1002/(sici)1521-4184(19996)332:6<195::aid-ardp195>3.3.co;2-8
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[meso-1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]sulfato-platinum(II) — Pharmacokinetic Studies

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Cited by 6 publications
(17 citation statements)
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“…In recent publications (Schlemmer et al 1999a;Bernhardt et al 1999) we have shown that the ER-anic [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]platinum(II) complexes, meso-1-PtLL¢; L,L¢ Cl 2 and H 2 O, SO 4 caused strong activity on hormonesensitive (i.e., ER + ), rodent breast cancers, mainly due to their estrogenic side eects. An ER-mediated drug accumulation in the nucleus of the tumor cell followed by an increased formation of DNA-intrastrand crosslinks is unlikely as cause of action (mechanism A).…”
Section: Introductionmentioning
confidence: 69%
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“…In recent publications (Schlemmer et al 1999a;Bernhardt et al 1999) we have shown that the ER-anic [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]platinum(II) complexes, meso-1-PtLL¢; L,L¢ Cl 2 and H 2 O, SO 4 caused strong activity on hormonesensitive (i.e., ER + ), rodent breast cancers, mainly due to their estrogenic side eects. An ER-mediated drug accumulation in the nucleus of the tumor cell followed by an increased formation of DNA-intrastrand crosslinks is unlikely as cause of action (mechanism A).…”
Section: Introductionmentioning
confidence: 69%
“…An ER-mediated drug accumulation in the nucleus of the tumor cell followed by an increased formation of DNA-intrastrand crosslinks is unlikely as cause of action (mechanism A). Such an interference in the metabolism of the tumor cell was formerly postulated by us for meso-1-PtLL¢ (Schlemmer et al 1999a;Bernhardt et al 1999;Karl et al 1988). …”
Section: Introductionmentioning
confidence: 72%
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“…The corrected cell number of a leukocyte subpopulation was calculated according to the equation --- 2) Up to now experiments on breast cancer bearing animals to detect a TAM number reducing potency of phytoestrogens have not been performed. 3) In preceding publications of this series [8,9] we have shown that the anti-breast cancer activity of meso-1-PtCl2 is caused by its estrogenic potency and that a cDDP-like mode of action does not substantially contribute to the inhibition of the tumor. Studies with 1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethane, the hormonally active pharmacophor of meso-1-PtCl2, which, despite the absence of the cytotoxic PtCl2-group, also inhibits the growth of the murine MXT-M-3,2 breast cancer, confirm the discussed mode of action [15,16] .…”
Section: Experimental Schedulementioning
confidence: 99%
“…Like steroidal and non-steroidal estrogens [7][8][9] or selective estrogen receptor modulators (SERMs) [10,11] , phytoestrogens are thought to be also useful as drugs in the therapy and prevention of breast cancer [12][13][14] .…”
mentioning
confidence: 99%