Mesenchymal stromal cells: potential roles in graft‐versus‐host disease prophylaxis and treatment

Maziarz, Richard T.

doi:10.1111/trf.13563

Cited by 9 publications

(7 citation statements)

References 37 publications

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“…Other dilemmas impacting the widespread clinical use of MSCs that researchers have yet to reach a consensus for are which tissue source yields the most effective product, combined with the significant impact of donor variability and continued passaging on cell growth, protein production, and EV release [85, 110]. Furthermore, there is a lack of standardized disease-specific procedures and clinical trial regulations regarding the magnitude (average of 1-2 million cells/kg body weight) and frequency of dose administration, the use of allogeneic vs .…”

Section: Clinical Applications Of Mscs In Diseases Mediated By Immmentioning

confidence: 99%

Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System

Guerrouahen

Sidahmed

Sulaiti

et al. 2019

Stem Cells International

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Mesenchymal stromal cells (MSCs), formerly known as mesenchymal stem cells, are nonhematopoietic multipotent cells and are emerging worldwide as the most clinically used and promising source for allogeneic cell therapy. MSCs, initially obtained from bone marrow, can be derived from several other tissues, such as adipose tissue, placenta, and umbilical cord. Diversity in tissue sourcing and manufacturing procedures has significant effects on MSC products. However, in 2006, a minimal set of standard criteria has been issued by the International Society of Cellular Therapy for defining derived MSCs. These include adherence to plastic in conventional culture conditions, particular phenotype, and multilineage differentiation capacity in vitro. Moreover, MSCs have trophic capabilities, a high in vitro self-renewal ability, and immunomodulatory characteristics. Thus, immunosuppressive treatment with MSCs has been proposed as a potential therapeutic alternative for conditions in which the immune system cells influence outcomes, such as inflammatory and autoimmune diseases. The precise mechanism by which MSCs affect functions of most immune effector cells is not completely understood but involves direct contact with immune cells, soluble mediators, and local microenvironmental factors. Recently, it has been shown that their homeostatic resting state requires activation, which can be achieved in vitro with various cytokines, including interferon-γ. In the present review, we focus on the suppressive effect that MSCs exert on the immune system and highlight the significance of in vitro preconditioning and its use in preclinical studies. We discuss the clinical aspects of using MSCs as an immunomodulatory treatment. Finally, we comment on the risk of interfering with the immune system in regard to cancer formation and development.

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Section: Clinical Applications Of Mscs In Diseases Mediated By Immmentioning

confidence: 99%

Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System

Guerrouahen

Sidahmed

Sulaiti

et al. 2019

Stem Cells International

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“…This impact of B lymphocytes on T lymphocyte regulatory pathways is supported by the results of an observational study on B lymphocyte depletion drugs and B lymphocyte signaling inhibitors as treatment for GVHD, particularly in sex-mismatched HCT 46,47 . Novel cellular therapy agents such as mesenchymal stem cells have been shown to induce local tissue tolerance 48,49 . This therapy has been effective in treating gut GVHD and preventing GVHD 50 .…”

Section: Improved Success By Overcoming Immunological Barriersmentioning

confidence: 99%

Hematopoietic Stem Cell Transplantation, Where Have We Come and Where Do We Go

Gajewski

2020

BCT

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Several studies in the 1980s demonstrated that survival results from HLA closely phenotypically matched relatives and the limited number of unrelated donors approximated HLA genotypic sibling matched results which led to the enthusiasm being generated to initiate registries of unrelated donors who are willing to donate marrow or peripheral blood progenitors [15][16][17][18] . This enthusiasm was further abetted by the identification of linkage disequilib-

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“…A criopreservação de embriões é agora um procedimento de rotina e existem dados publicados suficientes que apoiam a sua eficácia. Em se tratando de perspectivas futuras, em se tratando de estatísticas, tem-se que o número de transferência de embriões aumentou maus de 2,5 vezes nos últimos 20 anos, contudo quando se discutem embriões congelados e seu uso na prática clínica, a primeira questão que surge é o risco para a prole, quando estamos aplicando essa tecnologia (PUSCHMANN et al, 2014;MAZIARZ et al, 2016;JANG et al, 2017). Em alguns exemplares destas espécies realizou-se a superovulação, retirando os óvulos e fecundando-os in vitro, sendo posteriormente implantados em uma "mãede-aluguel".…”

Section: Processos De Criopreservação E Seus Componentesunclassified

Biotecnologia Como Ferramenta Para O Conhecimento E Conservação Da Fauna E Flora Amazônica

Vidal¹,

Chaves²,

Silva³

2019

Genética E Melhoramento De Plantas E Animais

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Mesenchymal stromal cells: potential roles in graft‐versus‐host disease prophylaxis and treatment

Cited by 9 publications

References 37 publications

Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System

Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System

Hematopoietic Stem Cell Transplantation, Where Have We Come and Where Do We Go

Biotecnologia Como Ferramenta Para O Conhecimento E Conservação Da Fauna E Flora Amazônica

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