Hematopoietic Stem Cell Transplantation, Where Have We Come and Where Do We Go

Abstract

Several studies in the 1980s demonstrated that survival results from HLA closely phenotypically matched relatives and the limited number of unrelated donors approximated HLA genotypic sibling matched results which led to the enthusiasm being generated to initiate registries of unrelated donors who are willing to donate marrow or peripheral blood progenitors [15][16][17][18] . This enthusiasm was further abetted by the identification of linkage disequilib-