2021
DOI: 10.3390/ijms22147447
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Mesenchymal Stem Cells Therapies on Fibrotic Heart Diseases

Abstract: Stem cell therapy is a promising alternative approach to heart diseases. The most prevalent source of multipotent stem cells, usually called somatic or adult stem cells (mesenchymal stromal/stem cells, MSCs) used in clinical trials is bone marrow (BM-MSCs), adipose tissue (AT-MSCs), umbilical cord (UC-MSCs) and placenta. Therapeutic use of MSCs in cardiovascular diseases is based on the benefits in reducing cardiac fibrosis and inflammation that compose the cardiac remodeling responsible for the maintenance of… Show more

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Cited by 25 publications
(19 citation statements)
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References 141 publications
(155 reference statements)
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“…On injured pancreatic islets, beneficial effects are consequent to the immunomodulatory, anti-inflammatory and anti-apoptotic actions of the molecules secreted by MSCs, which protect endogenous β-cells, stimulate their regeneration and proliferation and ameliorate insulin resistance, reversing hyperglycemia, the main determinant of DCM [ 102 ]. Regarding cardiac repair, MSCs have protective and regenerative effects in several types of cardiovascular diseases [ 103 ]. They can differentiate into cardiomyocytes, endothelial cells and vascular smooth muscle cells [ 104 ], but, again, rather than cellular replacement, tissue repair seems mainly related to MSCs’ secretome, through which they suppress inflammatory responses and induce neovascularization, resulting in cardiac tissue preservation [ 105 ].…”
Section: Preclinical and Clinical Approaches To Msc In Diabetes-induced Cardiac Complicationsmentioning
confidence: 99%
“…On injured pancreatic islets, beneficial effects are consequent to the immunomodulatory, anti-inflammatory and anti-apoptotic actions of the molecules secreted by MSCs, which protect endogenous β-cells, stimulate their regeneration and proliferation and ameliorate insulin resistance, reversing hyperglycemia, the main determinant of DCM [ 102 ]. Regarding cardiac repair, MSCs have protective and regenerative effects in several types of cardiovascular diseases [ 103 ]. They can differentiate into cardiomyocytes, endothelial cells and vascular smooth muscle cells [ 104 ], but, again, rather than cellular replacement, tissue repair seems mainly related to MSCs’ secretome, through which they suppress inflammatory responses and induce neovascularization, resulting in cardiac tissue preservation [ 105 ].…”
Section: Preclinical and Clinical Approaches To Msc In Diabetes-induced Cardiac Complicationsmentioning
confidence: 99%
“…On the other hand, there have been numerous clinical trials that recently proposed MSCs as a promising therapeutic agent to treat several diabetic complications, including DCM [5,6] . Orlic et al [18] demonstrated that locally delivered autologous BM-MSCs to mice with infarcted hearts could result in regeneration of damaged myocardium.…”
Section: Discussionmentioning
confidence: 99%
“…In recent decades, from a therapeutic perspective and facilitated by the ease of preparation and immunologic privilege, multipotent mesenchymal stem cells (MSCs) have been used systemically or locally as an extremely promising therapeutic agent to treat various diseases, including diabetes complications and heart diseases [1,5] . Therefore, MSCs transplantation has been widely used as an effective method of protecting the damaged myocardium and improving cardiac function in many nonischemic or ischemic heart diseases, since they can migrate to injured cardiac sites and regenerate heart tissues by paracrine mediators that could alleviate the established DCM by supporting other cells' nutrition and environment [6] . MSCs were found to possess wide repertoires of growth factors including hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), and some cytokines/chemokines.…”
Section: Introductionmentioning
confidence: 99%
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“…Instead, the mechanisms underlying their beneficial effects in vivo are rather related to their paracrine activity [ 21 , 22 , 23 , 24 ]. MSCs have the ability to secrete various bioactive molecules, including cytokines, chemokines, growth factors, microRNAs (miRs), and extracellular vesicles (EVs), that have positive effects on failing hearts by attenuating the degree of cardiac fibrosis [ 25 ].…”
Section: Introductionmentioning
confidence: 99%