Mesenchymal stem cells secrete factors that inhibit inflammatory processes in short-term osteoarthritic synovium and cartilage explant culture

Anti-Inflammatory Strategies in Cartilage Repair

“…101,102 In an inflammatory environment, MSCs secrete factors which cause multiple anti-inflammatory effects and influence matrix turnover in synovium and cartilage explants. 103 MSCs have also been revealed as robust sources of TIMP-mediated MMP-inhibition, capable of protecting the perivascular niche from high levels of destructive MMPs, even under pathological conditions. 104 Due to their potential to modulate the local microenvironment via anti-inflammatory and immunosuppressive functions, MSCs have an additional advantage for allogeneic application (Fig.…”

Treatment of Knee Osteoarthritis with Autologous Expanded Bone Marrow Mesenchymal Stem Cells: 50 Cases Clinical and MRI Results at One Year Follow-Up

“…Normal hyaline cartilage shows an increase of T2 values from deep to superficial cartilage. Deeper zones with dense collagen mesh and greater PG content have shorter T2 values than the transitional zone with greater water content and thus greater T2 values [18].…”

“…Many studies show co-cultured MSC to induce chondrocyte proliferation and extracellular matrix protein synthesis, including aggrecan and type II collagen [16,17]. The capacity to differentiate into cells of the chondrogenic lineage and produce extracellular matrix together with their proven anti-inflammatory potential brought to focus MSC as a potential treatment for osteoarthitis [18].…”

Do Mesenchymal Stem Cells Have a Role to Play in Cutaneous Wound Healing?

“…[32][33][34] Additionally, MSCs have shown to down-modulate inflammation directly or by secreting factors that cause multiple anti-inflammatory effects. 35,36 Finally, MSCs were found to decrease apoptosis possibly by activation of the stannicalcin-1. 37 It is worth mentioning that these issues are currently poorly understood and the basic science research on MSC is mainly carried out either in animal models or using culture-expanded human MSCs.…”