Mesenchymal Stem Cells Promote Formation of Colorectal Tumors in Mice

Tsai, Kuo–Shu; Yang, Shung‐Haur; Lei, Yen–Ping; Tsai, Chih–Chien; Chen, Hsin–Wei; Hsu, Chih–Yuan; Chen, Ling–Lan; Wang, Hsei‐Wei; Miller, Stephanie A.; Chiou, Shih‐Hwa; Hung, Mien‐Chie; Hung, Shih‐Chieh

doi:10.1053/j.gastro.2011.05.045

Cited by 149 publications

(125 citation statements)

References 27 publications

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“…Several studies demonstrated anti-tumor effects [8][9][10] whereas others showed tumor promoting effects [11][12][13] of MSCs in different tumor models. Regarding the effects on CRC, most of the studies have shown a pro-cancer effect of MSCs [29][30][31]. Consistently, we observed that trophic factors secreted by MSCs can promote colony formation and growth of a metastasis CRC cell line.…”

Section: Discussionsupporting

confidence: 88%

Mesenchymal Stem/Stromal Cells Exert Trophic Effect on Colorectal Cancer Metastasis to the Liver

Hernanda¹,

Gonzalez²

2016

J Liver

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Colorectal Cancer (CRC) is the third most common cancer in the world. CRC tends to metastasize to the liver, which may occur in 20% to 70% of patients and represents the major cause of death. Mesenchymal Stem/stromal cells (MSCs) have shown to be able to migrate to CRC site and play an important role in tumor progression. We have previously identified a resident MSC population in the liver. Therefore, this study aims to investigate whether there is infiltration of MSCs into patient CRC Liver Metastasis (CRC-LM) and their potential effects on tumor cell growth. By culturing resected patient CRC-LM tissue, we observed the emerging of fibroblast-like cells. Further phenotype and functional characterization confirmed their bonafide MSCs features. In situ staining with a well-established MSCs marker showed a significant enrichment of candidate MSCs in patient CRC-LM, particularly the tumor-stromal area. Moreover, MSCs secreted trophic factors significantly increased colony formation and growth of a metastatic CRC cell line. In summary, we found infiltration and enrichment of MSCs in CRC-LM patient, which could in turn nourish tumor cells.

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Section: Discussionsupporting

confidence: 88%

Mesenchymal Stem/Stromal Cells Exert Trophic Effect on Colorectal Cancer Metastasis to the Liver

Hernanda¹,

Gonzalez²

2016

J Liver

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“…125,126 Similarly, cytokines secreted by MSCs, which include IL-6 and IL-8, have been demonstrated to enhance cancer cell malignancy in the context of several cancers, such as breast 6 or colorectal. 127 Finally, MSC-derived growth factors, such as epidermal growth factor (EGF), act on their cognate receptors on the surface of cancer cells, enhancing tumorigenesis in the setting of breast cancer. 8 While the list of MSC-derived peptide messengers is expanding, it is important to note that MSCs can also provide additional agents/materials that can act on the cancer cells in a paracrine fashion.…”

Section: Mscs In Tumor Pathogenesismentioning

confidence: 99%

Mesenchymal stem cells in tumor development

Cuiffo¹,

Karnoub²

2012

Cell Adhesion & Migration

165

118

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“…Carcinoma-associated MSCs (CA-MSCs) promoted tumor growth by increasing the number of cancer stem cells through bone morphogenetic protein signaling (32). Other pathways include the WNT, TGF-β (33) and the IL-6̸JAK2̸STAT3 signaling pathways (34,35). In addition, a pathway may be induced by tumor cells, which results in the enhancement of the stemness of tumor cells.…”

Section: Functions In the Tumor Microenvironmentmentioning

confidence: 99%

Mesenchymal stem cells in the tumor microenvironment

Guan

Chen

2013

Biomedical Reports

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Abstract. Mesenchymal stem cells (MSCs) are non-hematopoietic, multipotent cells, which are able to differentiate to bone, adipose and cartilage tissue. MSCs have the characteristic of migration to injured areas or tumor microenvironment following induction by chemokines or inflammatory factors. An increasing number of studies have reported that MSCs recruited to the tumor microenvironment play various roles in tumor cell development and tumor progression. In this study, we reviewed the studies related to the tumor-promoting roles of MSCs from several aspects, such as increasing stemness of tumor cells, mediating migration, promoting angiogenesis, suppressing immune response and inducing drug resistance.

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Mesenchymal Stem Cells Promote Formation of Colorectal Tumors in Mice

Cited by 149 publications

References 27 publications

Mesenchymal Stem/Stromal Cells Exert Trophic Effect on Colorectal Cancer Metastasis to the Liver

Mesenchymal Stem/Stromal Cells Exert Trophic Effect on Colorectal Cancer Metastasis to the Liver

Mesenchymal stem cells in tumor development

Mesenchymal stem cells in the tumor microenvironment

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