Mesenchymal stem cells in tumor development

Cuiffo, Benjamin G.; Karnoub, Antoine E.

doi:10.4161/cam.20875

Cited by 167 publications

(126 citation statements)

References 172 publications

(169 reference statements)

Supporting

Mentioning

120

Contrasting

Unclassified

Order By: Relevance

“…CAFs can (1) alter cell-matrix interactions that control epithelial cell sensitivity to apoptosis, (2) secrete proteins that control epithelial cell survival and proliferation, (3) contribute to direct cell-cell interactions where cells can exchange membrane fragments (trogocytosis) and communicate, (4) create physical barriers that facilitate the acquisition of drug resistance, and (5) activate epigenetic plasticity in neighboring cells. Thus, CAFs alter the physical, dimensional, and chemical aspects of tissues in an ongoing dynamic and coevolutionary manner (Cuiffo and Karnoub 2012;Junttila and de Sauvage 2013).…”

Section: Cafs and Disease Progressionmentioning

confidence: 99%

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

2016

View full text Add to dashboard Cite

The tumor stroma is no longer seen solely as physical support for mutated epithelial cells but as an important modulator and even a driver of tumorigenicity. Within the tumor stromal milieu, heterogeneous populations of fibroblast-like cells, collectively termed carcinoma-associated fibroblasts (CAFs), are key players in the multicellular, stromal-dependent alterations that contribute to malignant initiation and progression. This review focuses on novel insights into the contributions of CAFs to disease progression, emergent events leading to the generation of CAFs, identification of CAF-specific biomarkers predictive of disease outcome, and recent therapeutic approaches aimed at blunting or reverting detrimental protumorigenic phenotypes associated with CAFs.

show abstract

Section: Cafs and Disease Progressionmentioning

confidence: 99%

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

2016

View full text Add to dashboard Cite

show abstract

“…2 Among the several conditions able to recruit MSC, tumors are particularly efficient, thus, large number of MSC participate to the developing tumorassociated stroma. 3 Indeed, MSC labeled ex vivo and injected i.v. into tumor-bearing animals localize preferentially to tumor microenvironment.…”

Section: Introductionmentioning

confidence: 99%

Extracellular acidity strengthens mesenchymal stem cells to promote melanoma progression

et al. 2015

View full text Add to dashboard Cite

“…Recent studies indicate that mouse MSCs readily undergo chromosomal instability while human MSCs are more genetically stable (Rodriguez et al 2012). However the trophic functions of human MSCs may stimulate tumor cell invasion, proliferation motility, and metastasis (Cuiffo and Karnoub 2012). Finally, HSC expansion was found to be associated with the increased expression of genes implicated in oncogenic transformation as well (Okamoto et al 2007).…”

Section: Current Limitations In the Use Of Stem Cells For Therapeuticmentioning

confidence: 98%

Stem cell bioprocess engineering towards cGMP production and clinical applications

Sart

Schneider

et al. 2014

Cytotechnology

View full text Add to dashboard Cite

Stem cells, including mesenchymal stem cells and pluripotent stem cells, are becoming an indispensable tool for various biomedical applications including drug discovery, disease modeling, and tissue engineering. Bioprocess engineering, targeting large scale production, provides a platform to generate a controlled microenvironment that could potentially recreate the stem cell niche to promote stem cell proliferation or lineage-specific differentiation. This survey aims at defining the characteristics of stem cell populations currently in use and the present-day limits in their applications for therapeutic purposes. Furthermore, a bioprocess engineering strategy based on bioreactors and 3-D cultures is discussed in order to achieve the improved stem cell yield, function, and safety required for production under current good manufacturing practices.

show abstract

Mesenchymal stem cells in tumor development

Cited by 167 publications

References 172 publications

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

Extracellular acidity strengthens mesenchymal stem cells to promote melanoma progression

Stem cell bioprocess engineering towards cGMP production and clinical applications

Contact Info

Product

Resources

About