2014
DOI: 10.1007/s10616-013-9687-7 View full text |Buy / Rent full text
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Abstract: Stem cells, including mesenchymal stem cells and pluripotent stem cells, are becoming an indispensable tool for various biomedical applications including drug discovery, disease modeling, and tissue engineering. Bioprocess engineering, targeting large scale production, provides a platform to generate a controlled microenvironment that could potentially recreate the stem cell niche to promote stem cell proliferation or lineage-specific differentiation. This survey aims at defining the characteristics of stem ce… Show more

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“…Research in the stem cell field has shown that cultivation conditions have a significant influence on hPSC expansion processes. Even small changes in oxygen tension, pH, or medium composition/concentrations have the potential to cause significant changes in cell proliferation . Therefore, advanced control algorithms (e.g., model predictive control, gain scheduling control methods and adaptive control systems) and process monitoring methods (e.g., soft‐sensors, state‐estimation algorithms and particle filter algorithms) should be applied for maintenance of optimized time profiles of important process variables.…”
Section: Process Optimization Monitoring and Controlmentioning
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“…Research in the stem cell field has shown that cultivation conditions have a significant influence on hPSC expansion processes. Even small changes in oxygen tension, pH, or medium composition/concentrations have the potential to cause significant changes in cell proliferation . Therefore, advanced control algorithms (e.g., model predictive control, gain scheduling control methods and adaptive control systems) and process monitoring methods (e.g., soft‐sensors, state‐estimation algorithms and particle filter algorithms) should be applied for maintenance of optimized time profiles of important process variables.…”
Section: Process Optimization Monitoring and Controlmentioning
“…Even small changes in oxygen tension, pH, or medium composition/concentrations have the potential to cause significant changes in cell proliferation. 15,22 Therefore, advanced control algorithms (e.g., model predictive control, gain scheduling control methods and adaptive control systems) and process monitoring methods (e.g., soft-sensors, state-estimation algorithms and particle filter algorithms) should be applied for maintenance of optimized time profiles of important process variables. Such monitoring and control systems are already applied in some cases for maintenance of bacterial and mammalian cultivation processes.…”
Section: Process Optimization Monitoring and Controlmentioning
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“…• Bioprocess considerations: What is required to create scalable and robust manufacturing processes [7] are considered. Understand and control the mechanism of action and use of reliable potency assays.…”
Section: Key Pharmaceutical Factors To Consider In Early Development mentioning