Mesenchymal stem cells isolated from both distal femurs of patients with unilateral trauma or osteoarthritis of the knee exhibit similar in-vitro ability of bone formation

MSCs from polytrauma patients: preliminary comparative study with MSCs from elective-surgery patients

“…In inflammatory conditions, MSCs tend to produce anti-inflammatory molecules to modulate microenvironment and immune system dysregulation, as occurs after polytrauma [ 24 ]. In our study, the immunomodulatory profile of MSCs showed no differences in the expression of genes involved in immunomodulation between groups, which can be potentially due to the absence of continuous stimuli during culture expansion may reduce MSCs anti-inflammatory expression profile [ 12 , 28 ]. For future studies, it would be interesting to evaluate the genetic profile of sorted non-expanded BM-MSCs during the first days after patient hospital admission.…”

“…Although the information on preclinical models of polytrauma is extensive, information on human samples is limited. In one study, MSCs from patients with unilateral trauma or osteoarthritis, but not with polytrauma, did not show any difference in proliferative and differentiation capacities comparing to non-traumatic and chronic bone disorder [ 28 ]. Nevertheless, in another study, when MSCs were stimulated in vitro with serum from polytrauma patients (right after hospital admission) revealed a significant increase in proliferative potential [ 12 ].…”