Mesenchymal Stem Cells in Burn Wound Management

Abstract

Mesenchymal stem cells have a known regenerative potential and are used in many indications. They secrete many growth factors, including for fibroblasts (FGF), endothelium (VEGF), as well as 14 anti-inflammatory cytokines, and they stimulate tissue regeneration, promoting the secretion of proteins and glycosaminoglycans of extracellular matrices, such as collagen I, II, III, and V, elastin, and also metalloproteinases. They secrete exosomes that contain proteins, nucleic acids, lipids, and enzymes. In addition, they show the activity of inactivating free radicals. The aim of this study was an attempt to collect the existing literature on the use of stem cells in the treatment of a burn wound. There were 81 studies included in the analysis. The studies differed in terms of the design, burn wound model, source of stem cells, and methods of cellular therapy application. No major side effects were reported, and cellular therapy reduced the healing time of the burn wound. Few case reports on human models did not report any serious adverse events. However, due to the heterogeneity of the evidence, cellular therapy in burn wound treatment remains an experimental method.

Microbial community succession in the intestine of mice with deep partial-thickness burns

“…In addition to the physical damage that they can inflict, burns have also been shown to result in psychological sequelae for patients ( Farag et al, 2018 ; Al-Ghabeesh, 2022 ). Despite their widespread occurrence, there is still much to be understood about the effects of burns on the human body and potential approaches for improving treatment ( Moreira et al, 2018 ; Surowiecka et al, 2022 ). One area of particular interest is the impact of burns on the gut microbiome, as variations in the composition of the microbial community in the intestine have been associated with a range of health outcomes ( Biagi et al, 2016 ; Adak and Khan, 2019 ).…”