Mesenchymal stem cells and hyaluronic acid for bone grafting

Teixeira, Eduardo Rolim; Boeckel, Daniel Gonçalves; Sesterheim, Patrícia; Fulginiti, Roberta Limeira; Shinkai, Rosemay

doi:10.1111/clr.12_13356

Cited by 4 publications

(3 citation statements)

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“…These osteogenic properties of hyaluronic acid are molecular weight- and concentration-dependent [ 56 ]. Other studies have indicated that HA favors osteogenesis [ 57 , 58 ]. Having HA as part of the scaffold components can give the material the ability to bind water to it [ 59 ].…”

Section: Resultsmentioning

confidence: 99%

Novel PVA–Hyaluronan–Siloxane Hybrid Nanofiber Mats for Bone Tissue Engineering

Sánchez-Téllez,

Baltierra-Uribe,

Vidales-Hurtado

et al. 2024

Polymers

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Hyaluronan (HA) is a natural biodegradable biopolymer; its biological functions include cell adhesion, cell proliferation, and differentiation as well as decreasing inflammation, angiogenesis, and regeneration of damaged tissue. This makes it a suitable candidate for fabricating nanomaterials with potential use in tissue engineering. However, HA nanofiber production is restricted due to the high viscosity, low evaporation rate, and high surface tension of HA solutions. Here, hybrids in the form of continuous and randomly aligned polyvinyl alcohol (PVA)–(HA)–siloxane nanofibers were obtained using an electrospinning process. PVA–HA fibers were crosslinked by a 3D siloxane organic–inorganic matrix via sol-gel that restricts natural hydrophilicity and stiffens the structure. The hybrid nanofiber mats were characterized by FT-IR, micro-Raman spectroscopy, SEM, and biological properties. The PVA/HA ratio influenced the morphology of the hybrid nanofibers. Nanofibers with high PVA content (10PVA-8 and 10PVA-10) form mats with few beaded nanofibers, while those with high HA content (5PVA-8 and 5PVA-10) exhibit mats with mound patterns formed by “ribbon-like” nanofibers. The hybrid nanofibers were used as mats to support osteoblast growth, and they showed outstanding biological properties supporting cell adhesion, cell proliferation, and cell differentiation. Importantly, the 5PVA-8 mats show 3D spherical osteoblast morphology; this suggests the formation of tissue growth. These novel HA-based nanomaterials represent a relevant advance in designing nanofibers with unique properties for potential tissue regeneration.

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Section: Resultsmentioning

confidence: 99%

Novel PVA–Hyaluronan–Siloxane Hybrid Nanofiber Mats for Bone Tissue Engineering

Sánchez-Téllez,

Baltierra-Uribe,

Vidales-Hurtado

et al. 2024

Polymers

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“…Studies have indicated that HA is favorable for osteogenesis (Lin‐Shu, Thompson, Heidaran, Poser, & Spiro, 1999; Teixeira et al, 2018). HA enhances bone growth, acting a vector for osteoinductive compounds (Sudheesh Kumar, Hashimi, Saifzadeh, Ivanovski, & Vaquette, 2018) and promoting even distribution and increased density of newly formed bone, thereby altering the scaffold morphology and improving mineralization (Al‐Khateeb & Olszewska‐Czyz, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…The use of HA in oral and maxillofacial surgery (OMFS) has been described in many publications. A recent review documented the use of HA in dental Studies have indicated that HA is favorable for osteogenesis (Lin- Shu, Thompson, Heidaran, Poser, & Spiro, 1999;Teixeira et al, 2018).…”

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confidence: 99%

Use of hyaluronic acid for regeneration of maxillofacial bones

D'Albis¹,

D'Albis

Palma

et al. 2022

Genesis

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Summary Hyaluronic acid (HA) has been widely used in medicine and is currently of particular interest to maxillofacial surgeons. Several applications have been introduced, including those in which HA is used as a scaffold for bone regeneration, either alone or in combination with other grafting materials, to enhance bone growth. This review aims to analyze the available literature on the use of HA for maxillofacial bone regenerative procedures including socket preservation, sinus augmentation, and ridge augmentation. Medline and PubMed databases were searched for relevant reports published between January 2000 and April 2021. Nine publications describing the use of HA to augment bone volume were identified. Although further studies are needed, these findings are encouraging as they suggest that HA could be used effectively used, in combination with graft materials, in maxillofacial bone regenerative procedures. HA facilitates manipulation of bone grafts, improves handling characteristics and promotes osteoblast activity that stimulates bone regeneration and repair.

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