Mesenchymal stem cells and cerebral palsy

New strategies accelerate the path to overcome refractory interstitial cystitis

“…J Chin Med Assoc easy and reproducible manner (accessibility, harvesting, potential, extraction by a non-terminal procedure) but also is absence of ethical concerns. 14,15 Additionally, besides nanofat, ASCs, and secretomes, the products of adipose tissue including macrofat, microfat, MCFs, the stromal vascular fraction (SVF), and exosomes, contributing to various needs for generative medicine, based on minimal or more manipulation procedure of the adipose tissue. 15 PRP, an autologous blood-derived product containing high platelet concentrations and other factors, influences various cellular processes, including homing of stem cells, cellular migration, proliferation, and differentiation, angiogenesis, macrophage activation, and collagen and matrix synthesis, to finish the enhancement of healing processes, immunomodulatory and paracrine properties of damaged tissue or organs.…”

“…12,15 The use of adipose tissue as a resource takes advantages, which not only can be obtained by easy and reproducible manner (accessibility, harvesting, potential, extraction by a non-terminal procedure) but also is absence of ethical concerns. 14,15 Additionally, besides nanofat, ASCs, and secretomes, the products of adipose tissue including macrofat, microfat, MCFs, the stromal vascular fraction (SVF), and exosomes, contributing to various needs for generative medicine, based on minimal or more manipulation procedure of the adipose tissue. 15…”

“…One is the adipose tissue-derived stem cells (ASCs, mainly as CD34+-rich ASCs): a subtype of mesenchymal stem (stroma) cells (MSCs), which possess differentiation ability, in vitro expansion, release of trophic materials, as well as angiogenic, antiapoptotic, and immune-modulatory properties. 14 In fact, nanofat is one of the richest sources of ASCs and other progenitor cells, and all are the critical component for the success of repair, healing and regeneration. 15 The other is to establish vascular and naive cellular matrix (a potential back-bone structure as ECM, microvascular fragments [MCFs, containing fragments of arterioles, venules, and capillaries identified by cluster of differentiation 31 [CD31 or platelet endothelial cell adhesion molecule-1] and α-smooth muscle actin, vascular endothelial growth factor [GF], platelet-derived GF, hepatocyte GF, hepatocyte GF, transforming GF-β, basic fibroblast GF, insulin-like GF 1, and granulocyte-macrophage colony-stimulating factor] and possible various pockets of GFs, cytokines, adipokines, and transcriptional factors [lipoxin, resolvins, protectins, neurotrophic factors, angiogenin, matrix metalloproteinase 9, leukemia inhibitory factor, macrophage migration factor, bone marrow protein 2, 4, and interleukin 1RA, 4, 8, 10, 11, and 13] which altogether from secretomes).…”

“…Regenerative medicine, a wide range of natural approaches which include the use medicine (agents, reagents, drugs), biologics, stem cell therapy, tissue engineering (using biodegradable porous three-dimensional scaffolds for mimicking the structure and functions of the natural ECM), cellular reprogramming, and gene therapy, curbs various diseases, mediated by repairment of the damaged tissue or organ and maintenance of essential function or restoration of the normal anatomy or function. [13][14][15] In the current article, 12 the authors explored the effect of biocellular regenerative medicine in the management of women with refractory IC by intravesical therapy with an autologous emulsification and filtration of the lipoaspirates and PRP. The aforementioned strategy took the following advantages.…”