Mesenchymal stem cell (MSC)-derived exosomes as a cell-free therapy for patients Infected with COVID-19: Real opportunities and range of promises

Rezakhani, Leila; Kelishadrokhi, Ali Fatahian; Soleimanizadeh, Arghavan; Rahmati, Shima

doi:10.1016/j.chemphyslip.2020.105009

Cited by 68 publications

(63 citation statements)

References 43 publications

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“…During the last two decades MSCs have been tested for treatment of various pathologic conditions, including acute and chronic lung diseases. The MSC-EV protective results against COVID-19, obtained recently, are solid as documented by several clinical trials, recently initiated or planned in several Countries [ 34 , 35 ].…”

Section: Protection Of the Covid-19 Diseasementioning

confidence: 95%

“…Interestingly, the MSC-EVs of mice were found stronger in their protection against ARDS if released from original cells pre-stimulated to release neurotrophic and immunomodulatory factors [ 40 ]. The result obtained by MSC-EVs could regulate, in infected patients the inflammatory responses, promoting tissue-repair and regeneration of damaged organs [ 34 , 37 – 39 ]. Moreover, the MSC-EVs, active by molecules of their cargo, could also operate against weak antiviral antibodies, which contribute to dysfunctional responses [ 31 ].…”

Section: Protection Of the Covid-19 Diseasementioning

confidence: 99%

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News About the Extracellular Vesicles from Mesenchymal Stem Cells: Functions, Therapy and Protection from COVID-19

Meldolesi

2021

Journal of Experimental Pathology

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This is a Commentary of a review about extracellular vesicles of immune cells published two years ago in Clinical and Experimental Immunology, a prestigious journal of the field. The aim is to establish whether, and to what extent, results in scientific area of the review have been extended and strengthened by innovative findings of considerable interest. The analysis of the recently published results has revealed that in various areas of the review developments have occurred. However, innovative findings have been only about the extracellular vesicles secreted by mesenchymal stem cells, usually indicated as MSC-EVs. Based on these findings, the Commentary has been focused on recent MSC-EVs findings presented in three Sections dealing with 1. recently appeared, relevant functions of the latter vesicles; 2. therapeutic processes developed according well known criteria, however innovative in many respects; and 3. protection of COVID-19 disease patients from organ lesions induced by the specific virus, SARS-CoV-2, during the disease. As everybody knows, the COVID-19 pandemic started at the end of 2019, thus after the publication of the aforementioned review. Data of Section 3 are therefore innovative, of great potential interest also at the clinical level, applied by translational medicine to various organs, from lung to brain, heart, kidney, immune and other cells. In view of its relevance, the author expects that research and medical use of MSC-EV, active at present, will be further developed, acquiring additional relevance in the near future.

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Section: Protection Of the Covid-19 Diseasementioning

confidence: 95%

Section: Protection Of the Covid-19 Diseasementioning

confidence: 99%

News About the Extracellular Vesicles from Mesenchymal Stem Cells: Functions, Therapy and Protection from COVID-19

Meldolesi

2021

Journal of Experimental Pathology

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“…Second, exosomes derived from mesenchymal stem cells. And last, incorporating specific mRNAs and miRNAs into exosomes elicit responses in patients (179). In 2005, results from two phase I clinical trials using DEX vaccines were obtained.…”

Section: Clinical Trials Using Exosome-based Vaccinesmentioning

confidence: 99%

Exosome-Based Vaccines: History, Current State, and Clinical Trials

2021

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Extracellular vesicles (EVs) are released by most cell types as part of an intracellular communication system in crucial processes such as inflammation, cell proliferation, and immune response. However, EVs have also been implicated in the pathogenesis of several diseases, such as cancer and numerous infectious diseases. An important feature of EVs is their ability to deliver a wide range of molecules to nearby targets or over long distances, which allows the mediation of different biological functions. This delivery mechanism can be utilized for the development of therapeutic strategies, such as vaccination. Here, we have highlighted several studies from a historical perspective, with respect to current investigations on EV-based vaccines. For example, vaccines based on exosomes derived from dendritic cells proved to be simpler in terms of management and cost-effectiveness than dendritic cell vaccines. Recent evidence suggests that EVs derived from cancer cells can be leveraged for therapeutics to induce strong anti-tumor immune responses. Moreover, EV-based vaccines have shown exciting and promising results against different types of infectious diseases. We have also summarized the results obtained from completed clinical trials conducted on the usage of exosome-based vaccines in the treatment of cancer, and more recently, coronavirus disease.

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“…Secretomes may be perfect for cell-free therapy in the treatment of gastrointestinal diseases, cancers, skin diseases, heart ischemic diseases, autoimmune disorders, can help for Covid-19 infected patients, and etc. [32][33][34]. However, there are very few clinical trials in this area and they have been conducted recently.…”

Section: Fth1 Ferritin Heavy Chainmentioning

confidence: 99%

Periosteum-Derived Mesenchymal Stem Cells Secretome - Cell-Free Strategy for Endogenous Bone Regeneration: Proteomic Analysis in Vitro

Pranskūnas¹,

Šimoliūnas²,

Alksnė³

et al. 2021

JOMR

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Objectives: Millions of people worldwide are affected by diseases or injuries which lead to bone/tooth loss and defects. While such clinical situations are daily practice in most of the hospitals, the widely used treatment methods still have disadvantages. Therefore, this field of medicine is actively searching new tissue regeneration techniques, one of which could be stem cell secretome. Thus, the purpose of this research study was to perform the detail proteomic analysis of periosteum-derived mesenchymal stem cells secretome in order to evaluate if it is capable to induce osteo-regenerative process. Material and Methods: Periosteum-derived mesenchymal stem cells (PMSCs) were extracted from adult male New Zealand White rabbits. Cells were characterised by evaluating their differentiation potential. After characterisation PMSCs secretomes were collected and their proteomic analysis was performed. Results: PMSCs were extracted from adult male New Zealand White rabbits. In order to characterise the extracted PMSCs, they were differentiated in the directions which mainly describes MSC multipotency -osteogenic, myogenic and adipogenic. A total of 146 proteins were detected. After characterisation PMSCs secretomes were collected and their proteomic analysis was performed. The resulting protein composition indicates the ability to promote bone regeneration to fully mature bone. Conclusions: Bioactive molecules detected in periosteum-derived mesenchymal stem cells secretome initiates the processes required for the formation of a fully functional bone.

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Mesenchymal stem cell (MSC)-derived exosomes as a cell-free therapy for patients Infected with COVID-19: Real opportunities and range of promises

Cited by 68 publications

References 43 publications

News About the Extracellular Vesicles from Mesenchymal Stem Cells: Functions, Therapy and Protection from COVID-19

News About the Extracellular Vesicles from Mesenchymal Stem Cells: Functions, Therapy and Protection from COVID-19

Exosome-Based Vaccines: History, Current State, and Clinical Trials

Periosteum-Derived Mesenchymal Stem Cells Secretome - Cell-Free Strategy for Endogenous Bone Regeneration: Proteomic Analysis in Vitro

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