Mesenchymal stem cell-derived exosomes as delivery vehicles for non-coding RNAs in lung diseases

Feng, Yuqian; Guo, Kaibo; Jiang, Jing; Lin, Shengyou

doi:10.1016/j.biopha.2023.116008

Cited by 4 publications

(6 citation statements)

References 139 publications

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“…MSC-exos offer a promising therapeutic approach for managing various lung diseases through multifaceted mechanisms. These exosomes, miRNAs, navigate through complex cellular pathways to exert anti-inflammatory, tissue reparative, antifibrotic, and immunomodulatory effects, addressing the pathological hallmarks of lung disorders such as chronic obstructive pulmonary disease (COPD), acute lung injury (ALI), and pulmonary fibrosis [ 191 ].…”

Section: Potential Therapeutic Applications In Disease and Regenerati...mentioning

confidence: 99%

“…By downregulating this pathway, MSC-exos reduce pro-inflammatory cytokine production, mitigating inflammation and protecting lung tissue from further damage. For instance, miR-451 modulates macrophage polarization towards the M2 phenotype, promoting tissue repair and resolving inflammation, which is crucial for attenuating conditions like burn-induced ALI [ 191 ].…”

Section: Potential Therapeutic Applications In Disease and Regenerati...mentioning

confidence: 99%

“…Beyond their anti-inflammatory effects, MSC-exos facilitate lung tissue repair by enhancing cell proliferation, migration, and angiogenesis. This is partly achieved through the modulation of autophagy via targeting the mTOR signaling pathway with miRNAs such as miR-100 and miR-377-3p [ 191 , 192 ].…”

Section: Potential Therapeutic Applications In Disease and Regenerati...mentioning

confidence: 99%

“…MSC-exo-derived miRNAs, including miR-29b-3p and miR-186, target fibrosis-related pathways such as the frizzled 6 (FZD6) and SRY-related HMG-box 4 (SOX4)/dickkopf 1 (DKK1) pathways, respectively [ 193 ]. By inhibiting fibroblast activation and collagen synthesis, these miRNAs prevent the progression of fibrotic changes in the lung, showcasing the antifibrotic potential of MSC-exos [ 191 ].…”

Section: Potential Therapeutic Applications In Disease and Regenerati...mentioning

confidence: 99%

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Therapeutic Applications of Stem Cell-Derived Exosomes

Abdulmalek,

Husain,

AlKhalifa

et al. 2024

IJMS

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Exosomes are extracellular vesicles of endosomal origin, ranging from 30 to 150 nm in diameter, that mediate intercellular transfer of various biomolecules, such as proteins, lipids, nucleic acids, and metabolites. They modulate the functions of recipient cells and participate in diverse physiological and pathological processes, such as immune responses, cell–cell communication, carcinogenesis, and viral infection. Stem cells (SCs) are pluripotent or multipotent cells that can differentiate into various cell types. SCs can also secrete exosomes, which exhibit remarkable therapeutic potential for various diseases, especially in the field of regenerative medicine. For example, exosomes derived from mesenchymal stem cells (MSCs) contain proteins, lipids, and miRNAs that can ameliorate endocrine disorders, such as diabetes and cancer. Exosomes from SCs (sc-exos) may offer similar advantages as SCs, but with reduced risks and challenges. Sc-exos have lower tumorigenicity, immunogenicity, and infectivity. They can also deliver drugs more efficiently and penetrate deeper into tissues. In this review, we provide an overview of the recent advances in sc-exos and their therapeutic applications in various diseases, such as diabetes and cancer. We also elucidate how the biological effects of sc-exos depend on their molecular composition. We also address the current challenges and future directions of using sc-exos.

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Section: Potential Therapeutic Applications In Disease and Regenerati...mentioning

confidence: 99%

Section: Potential Therapeutic Applications In Disease and Regenerati...mentioning

confidence: 99%

Section: Potential Therapeutic Applications In Disease and Regenerati...mentioning

confidence: 99%

Section: Potential Therapeutic Applications In Disease and Regenerati...mentioning

confidence: 99%

See 2 more Smart Citations

Therapeutic Applications of Stem Cell-Derived Exosomes

Abdulmalek,

Husain,

AlKhalifa

et al. 2024

IJMS

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“…Exosomes, particularly mesenchymal stem cell-derived exosomes, have been increasingly investigated for the treatment of pulmonary diseases, such as acute respiratory distress syndrome, chronic obstructive pulmonary disease, asthma, and pulmonary fibrosis [ 5 ]. The therapeutic impact of mesenchymal stem cell-derived exosomes is largely believed to be related to anti-inflammatory, antioxidant, and anti-apoptotic effects [ 6 ]. Further, various types of exosomes have been employed as drug carriers for chemotherapeutic agents, facilitating selective delivery of the drug to cancer cells [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Biodistribution of Platelet-Derived Regenerative Exosomes in a Porcine Model

Rizzo,

Bagwell,

Schiebel

et al. 2024

IJMS

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The purpose of this study was to evaluate the biodistribution of a platelet-derived exosome product (PEP), previously shown to promote regeneration in the setting of wound healing, in a porcine model delivered through various approaches. Exosomes were labeled with DiR far-red lipophilic dye to track and quantify exosomes in tissue, following delivery via intravenous, pulmonary artery balloon catheter, or nebulization in sus scrofa domestic pigs. Following euthanasia, far-red dye was detected by Xenogen IVUS imaging, while exosomal protein CD63 was detected by Western blot and immunohistochemistry. Nebulization and intravenous delivery both resulted in global uptake of exosomes within the lung parenchyma. However, nebulization resulted in the greatest degree of exosome uptake. Pulmonary artery balloon catheter-guided delivery provided the further ability to localize pulmonary delivery. No off-target absorption was noted in the heart, spleen, or kidney. However, the liver demonstrated uptake primarily in nebulization-treated animals. Nebulization also resulted in uptake in the trachea, without significant absorption in the esophagus. Overall, this study demonstrated the feasibility of pulmonary delivery of exosomes using nebulization or intravenous infusion to accomplish global delivery or pulmonary artery balloon catheter-guided delivery for localized delivery.

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Mesenchymal stem cell-based therapy for paraquat-induced lung injury

Zhang,

Li,

2024

Cell Biol Toxicol

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Paraquat poisoning results in significant pulmonary damage, but current treatments are only minimally effective in repairing the injured lung tissues. Recent research has highlighted the promise of using stem cell therapy, namely mesenchymal stem cells, as a new method for treating paraquat toxicity. These cells have shown effectiveness in decreasing inflammation, apoptosis, and fibrosis in the mice lungs subjected to paraquat. The therapeutic implications of mesenchymal stem cells are believed to arise from their release of bioactive proteins and their capacity to regulate inflammatory responses. However, additional clinical study is required to validate these therapies' efficacy. This review thoroughly explores the pathophysiology of paraquat poisoning and the properties of mesenchymal stem cells. Additionally, it critically assesses the long-term safety and effectiveness of mesenchymal stem cell therapies, which is crucial for developing more dependable and effective treatment protocols. In summary, although mesenchymal stem cells offer promising prospects for treating lung injuries, more investigations are required to optimize their therapeutic promise and ensure their safe clinical application in the context of paraquat poisoning. Supplementary Information The online version contains supplementary material available at 10.1007/s10565-024-09911-3.

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Mesenchymal stem cell-derived exosomes as delivery vehicles for non-coding RNAs in lung diseases

Cited by 4 publications

References 139 publications

Therapeutic Applications of Stem Cell-Derived Exosomes

Therapeutic Applications of Stem Cell-Derived Exosomes

Pulmonary Biodistribution of Platelet-Derived Regenerative Exosomes in a Porcine Model

Mesenchymal stem cell-based therapy for paraquat-induced lung injury

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