Mesenchymal/Epithelial Induction Mediates Olfactory Pathway Formation

LaMantia, Anthony‐Samuel; Bhasin, Naina; Kattron, Rhodes,; Heemskerk, Jill

doi:10.1016/s0896-6273(00)00121-5

Cited by 141 publications

(202 citation statements)

References 90 publications

(6 reference statements)

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“…Neurite-to-mesenchyme signaling is thought to be essential for initial ORN axons pathfinding and connectivity (Calof and Chikaraishi, 1989;LaMantia et al, 2000). The Wnt-␤catenin response on the surface of the FB could be elicited by signals from the OP, from the mesenchyme, or even from the FB.…”

Section: Orn To Mesenchymal Signals Induce Wnt-␤catenin Responsementioning

confidence: 99%

“…Numerous signals and cell populations, of both placodal and mesenchymal origin, are known to participate, such as the chemoattractant Netrin1 (Astic et al, 2002), semaphorins/neuropilins (Williams-Hogarth et al, 2000), Eph/Ephrins (Gao et al, 2000), Slit/Robo (Li et al, 1999), neural cell adhesion molecule (NCAM) (Treloar et al, 1997), Galectin1 (Puche et al, 1996), and p75 NGF receptor (Tisay et al, 2000). Retinoic acid, FGF8, sonic hedgehog, and bone morphogenetic proteins have been shown to mediate mesenchymal-OP interactions and initiate neurite outgrowth (LaMantia et al, 2000;Bashin et al, 2003). However, little is known about signals that mediate neurite-mesenchyme and mesenchyma-FB interactions, essential for connectivity.…”

Section: Introductionmentioning

confidence: 99%

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Activation of theWnt–βCatenin Pathway in a Cell Population on the Surface of the Forebrain Is Essential for the Establishment of Olfactory Axon Connections

Zaghetto¹,

Paina²,

Mantero³

et al. 2007

J. Neurosci.

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A variety of signals governing early extension, guidance, and connectivity of olfactory receptor neuron (ORN) axons has been identified; however, little is known about axon-mesoderm and forebrain (FB)-mesoderm signals. Using Wnt-␤catenin reporter mice, we identify a novel Wnt-responsive resident cell population, located in a Frizzled7 expression domain at the surface of the embryonic FB, along the trajectory of incoming ORN axons. Organotypic slice cultures that recapitulate olfactory-associated Wnt-␤catenin activation show that the ␤catenin response depends on a placode-derived signal(s). Likewise, in Dlx5Ϫ/Ϫ embryos, in which the primary connections fail to form, Wnt-␤catenin response on the surface of the FB is strongly reduced. The olfactory placode expresses a number of ␤catenin-activating Wnt genes, and the Frizzled7 receptor transduces the "canonical" Wnt signal; using Wnt expression plasmids we show that Wnt5a and Wnt7b are sufficient to rescue ␤catenin activation in the absence of incoming axons. Finally, blocking the canonical Wnt pathway with the exogenous application of the antagonists Dikkopf-1 or secreted-Frizzled-receptor protein-2 prevents ORN axon contact to the FB. These data reveal a novel function for Wnt signaling in the establishment of periphery-CNS olfactory connections and highlight a complex interplay between cells of different embryonic origin for ORN axon connectivity.

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Section: Orn To Mesenchymal Signals Induce Wnt-␤catenin Responsementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Activation of theWnt–βCatenin Pathway in a Cell Population on the Surface of the Forebrain Is Essential for the Establishment of Olfactory Axon Connections

Zaghetto¹,

Paina²,

Mantero³

et al. 2007

J. Neurosci.

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“…One such determinant may be retinoic acid (RA). In vitro, RA is known to promote neuronal differentiation and inhibit mesodermal characteristics of several cell types, including ORNs (Bain et al, 1996;LaMantia et al, 2000;Strubing et al, 1995). In vivo analyses also suggest that RA signaling is important in olfactory development, since hypoplasia and alterations in apoptosis occur in the frontonasal region when RA is depleted during embryonic development (Dickman et al, 1997).…”

Section: What Are the Early Determinants Of Progenitormentioning

confidence: 99%

Progenitor cells of the olfactory receptor neuron lineage

Calof

Bonnin

Crocker

et al. 2002

Microscopy Res & Technique

130

114

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The olfactory epithelium of the mouse has many properties that make it an ideal system for studying the molecular regulation of neurogenesis. We have used a combination of in vitro and in vivo approaches to identify three distinct stages of neuronal progenitors in the olfactory receptor neuron lineage. The neuronal stem cell, which is ultimately responsible for continual neuron renewal in this system, gives rise to a transit amplifying progenitor identified by its expression of a transcription factor, MASH1. The MASH1-expressing progenitor gives rise to a second transit amplifying progenitor, the Immediate Neuronal Precursor, which is distinct from the stem cell and MASH1-expressing progenitor, and gives rise quantitatively to olfactory receptor neurons. Regulation of progenitor cell proliferation and differentiation occurs at each of these three cell stages, and growth factors of the fibroblast growth factor (FGF) and bone morphogenetic protein (BMP) families appear to play particularly important roles in these processes. Analyses of the actions of FGFs and BMPs reveal that negative signaling plays at least as important a role as positive signaling in the regulation of olfactory neurogenesis.

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“…27 It has been also suggested that inductive interactions from the frontonasal-mesenchyme are essential for the morphogenesis of both the OE and the OB. 5,28 However, such work has not been extended to the very early stages of the olfactory placode formation. 5 At the early stages of development, an area of the rostral telencephalon of the mammalian brain is already specified as an OB primordium.…”

Section: Mutual Influences Between Oe and Obmentioning

confidence: 99%

The olfactory bulb as an independent developmental domain

López‐Mascaraque

Castro

2002

Cell Death Differ

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The olfactory system is a good model to study the mechanisms underlying guidance of growing axons to their appropriate targets. The formation of the olfactory bulb involves differentiation of several populations of cells and the initiation of the central projections, all under the temporal and spatial patterns of gene expression. Moreover, the nature of interactions between the olfactory epithelium, olfactory bulb and olfactory cortex at early developmental stages is currently of great interest. To explore these questions more fully, the present review aims to correlate recent data from different developmental studies, to gain insight into the mechanisms involved in the specification and development of the olfactory system. From our studies in the pax6 mutant mice (Sey Neu /Sey Neu ), it was concluded that the initial establishment of the olfactory bulb central projections is able to proceed independently of the olfactory sensory axons from the olfactory epithelium. The challenge that now remains is to consider the validity of the olfactory bulb as an independent development domain. In the course of evaluating these ideas, we will review the orchestra of molecular cues involved in the formation of the projection from the OB to the olfactory cortex.

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Mesenchymal/Epithelial Induction Mediates Olfactory Pathway Formation

Cited by 141 publications

References 90 publications

Activation of theWnt–βCatenin Pathway in a Cell Population on the Surface of the Forebrain Is Essential for the Establishment of Olfactory Axon Connections

Activation of theWnt–βCatenin Pathway in a Cell Population on the Surface of the Forebrain Is Essential for the Establishment of Olfactory Axon Connections

Progenitor cells of the olfactory receptor neuron lineage

The olfactory bulb as an independent developmental domain

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