Mesenchymal Dental Pulp Stem Cells

Lozano, Francisco Javier Rodríguez; Moraleda, José Marı́a

doi:10.1097/scs.0b013e318208ba61

Cited by 8 publications

(3 citation statements)

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“…Due to several modalities in sinus grafting, that is, external/internal approach, grafting with immediate or delayed implant placement and the variety of used filling materials (autologous bone, mixtures of autologous bone with bone substitute materials and bone substitute materials alone from different origins), the sinus lift procedure still remains an open area of research (Peleg et al 1999;Crespi et al 2009;Santagata et al 2010;Rodriguez Lozano & Moraleda 2011;Rosano et al 2011). The total replacement of autogenous bone by several bone substitute materials in sinus lifting has been discussed in numerous studies (Esposito et al 2010;Jensen et al 2012b).…”

Section: Discussionmentioning

confidence: 99%

Anorganic bovine bone (ABB) vs. autologous bone (AB) plus ABB in maxillary sinus grafting. A prospective non‐randomized clinical and histomorphometrical trial

Schmitt

Moest

Lutz

et al. 2014

Clinical Oral Implants Res

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The usage of ABB plus AB to a 1/1 ratio leads to an amount of newly formed bone comparable with the solitary use of ABB after grafting of the maxillary sinus. Considering that ABB is a non-resorbable bone substitute, it can be hypothesized that this leads to stable bone over time and long-term implant success. Importantly, in the sole use of ABB, bone grafting and therefore donor site morbidities can be avoided.

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Section: Discussionmentioning

confidence: 99%

Anorganic bovine bone (ABB) vs. autologous bone (AB) plus ABB in maxillary sinus grafting. A prospective non‐randomized clinical and histomorphometrical trial

Schmitt

Moest

Lutz

et al. 2014

Clinical Oral Implants Res

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“…e ., ectomesenchymal tissue) 16 . It has been reported that dental pulp plays a primary role in the regenerative response after an injury or trauma by secreting tertiary dentin and contributing to the differentiation of stem cells from dental pulp (DPSCs) into odontoblast-like cells 17,18 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of diffusion, cytotoxicity and tissue inflammatory reactions of four commercial bleaching products against human dental pulp stem cells

Llena

Collado-González

García‐Bernal

et al. 2019

Sci Rep

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Multiple side effects related to bleaching were found to occur in the dental pulp tissue, including decreased cell metabolism and viability. In this work we evaluated the in vitro diffusion capacity, cytotoxicity and biocompatibility of four commercial bleaching products on stem cells from human dental pulp ( h DPSCs). Two commercial bleaching gels hydrogen peroxide-based (HP), Norblanc Office 37.5% (Nor-HP) and Opalescence Boost 40% (Opal-HP) were applied for 30 min to enamel/dentine discs. Another two gels from the same manufacturers, 16% carbamide peroxide-based (CP), Norblanc Home (Nor-CP) and Opalescence CP 16% (Opal-CP), were applied for 90 min. The diffusion of HP was analysed by fluorometry. Cytotoxicity was determined using the MTT assays, the determination of apoptosis, immunofluorescence assays and intracellular reactive oxygen species (ROS) level. Tissue inflammatory reactions were evaluated histopathologically in rats. Statistical differences were performed by one-way ANOVA and Bonferroni post-test (α < 0.05). Normon products showed lower cytotoxicity and diffusion capacity than the Ultradent products. A high intracellular ROS level was measured in h DPSCs after exposure to Opal-HP. Finally, a severe necrosis of both coronal and radicular pulp was observed with Opal-HP. Similar concentrations of hydrogen peroxide and carbamide peroxide in a variety of bleaching products exhibited different responses in cells and dental pulp tissue, suggesting that bleaching products contain unknown agents that could influence their toxicity.

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“…Assim, o desenvolvimento de técnicas cirúrgicas que favoreçam a formação de novo osso em menor tempo é útil para a resolução de casos de deficiência em altura de rebordo na região posterior de maxila de forma mais rápida e eficiente. Recentemente, o uso de células tronco mesenquimais de diferentes origens foi proposto para o levantamento de seio maxilar (Smiler et al, 2007;Sauberbier et al, 2010;Rodríguez,Lozano,Moraleda, 2011), com os objetivos de acelerar o processo de neoformação óssea e resultar em formação de maior quantidade de osso vital.…”

Section: Introductionunclassified

Levantamento de seio maxilar com enxerto ósseo em neoformação associado a osso bovino inorgânico: avaliação clínica, histológica e histomorfométrica

Ferraz¹

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Sinus lift with newly forming bone and inorganic bovine bone: a clinical, histologic and histomorphometric evaluation The aim of this study is to evaluate the efficacy of newly forming bone graft (NFB) in the gain of bone height in sinus lift procedures. It were recruited for this study individuals 25-60 years of age, both genders, presenting a missing tooth at an upper premolar or molar region with 2-9 mm of remaining bone between alveolar ridge crest and sinus floor and the existence of an edentulous ridge or at least one tooth condemned to extraction. Sinus were treated by NFB mixed to inorganic bovine bone-IBB (test; n= 7) or IBB (control; n= 6). The volume of bone tissue was evaluated by computerized tomography obtained at baseline examination and 6 months after surgery. After this period, biopsies of hard tissue were obtained during implant installation for histologic and histomorphometric analysis. The analysis of data from tomographic images by t test showed that both materials were equally effective in the gain of bone height (test: 11.22 ± 0.60 mm vs. control: 11.82 ± 0.69 mm; p= 0.0664). The histologic analysis of tissue reaction around and between graft particles showed absence of significant differences between groups, according to Mann Whitney. Histomorphometric analysis showed greater percentage of vital bone (31.42% ± 11.13% vs. 16.38% ± 10.14%; p= 0.0002) and lower percentage of remaining particles (1.32% ± 2.34% vs. 3.15% ± 3.31%; p= 0.0306) and connective tissue (27.65% ± 12.34% vs. 35.02 ± 13.16; p= 0.0257) at test than control group. The mean diameter of remaining particles was greater at control than test group, according to t test (p= 0.0294), although no differences were observed between groups related to the area of direct contact between new bone and particles surface. These findings suggest that NFB is effective in the gain of bone height in sinus lift procedures, resulting in the formation of greater amount of vital bone with the use of IBB alone.

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Mesenchymal Dental Pulp Stem Cells

Cited by 8 publications

References 0 publications

Anorganic bovine bone (ABB) vs. autologous bone (AB) plus ABB in maxillary sinus grafting. A prospective non‐randomized clinical and histomorphometrical trial

Anorganic bovine bone (ABB) vs. autologous bone (AB) plus ABB in maxillary sinus grafting. A prospective non‐randomized clinical and histomorphometrical trial

Comparison of diffusion, cytotoxicity and tissue inflammatory reactions of four commercial bleaching products against human dental pulp stem cells

Levantamento de seio maxilar com enxerto ósseo em neoformação associado a osso bovino inorgânico: avaliação clínica, histológica e histomorfométrica

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