Mesalazine/hydroxypropyl-β-cyclodextrin/chitosan nanoparticles with sustained release and enhanced anti-inflammation activity

Tang, Peixiao; Sun, Qiaomei; Zhao, Ludan; Pu, Hongbin; Yang, Hongqin; Zhang, Shuangshuang; Gan, Ruixue; Gan, Na; Li, Hui

doi:10.1016/j.carbpol.2018.06.106

Cited by 53 publications

(24 citation statements)

References 30 publications

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“…Ye et al [26] synthesized blank NPs with a size of 238.5 to 391.2 nm and when these NPs were loaded with paclitaxel/dimethyl-β-CD, larger particles with diameters ranging from 440.2 to 521.4 nm were formed. In the present study also it was observed that the particle size increased with drug loading as reported in literature [28,[41][42][43][44] .…”

Section: Resultssupporting

confidence: 87%

“…The LC of AMD-loaded CSNPs varied between 8-9 % ( Table 2). Although the results obtained in this study are similar to the previous studies [25] , the LC in this study is slightly more effective [42] . It was found that increasing the amount of CD in NPs, which is used to increase the solubility of AMD, also increased the EE and LC of CSNPs, but this increase is not significant.…”

Section: Resultssupporting

confidence: 87%

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Synthesis of Chitosan Nanoparticles for Controlled Release of Amiodarone

Büyük¹,

Arayıcı²,

Derman³

et al. 2020

ijps

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Buyuk et al.: Amiodarone-loaded Chitosan NanoparticlesThis work is based on a natural polymer chitosan used in a nanoparticulate drug delivery system for the controlled release of amiodarone along with β-cyclodextrin. Amiodarone-loaded chitosan nanoparticles were prepared using the ionic gelation method aided by sonication. Amiodarone loading on chitosan nanoparticles was done under optimum conditions. For particle characterization; zeta-sizer, UV/Vis, Fourier-transform infrared spectroscopy, X-ray powder diffraction, differential scanning calorimeter and scanning electron microscope techniques were used. In vitro drug release studies of amiodaroneloaded chitosan nanoparticles were performed using the dialysis diffusion technique. Drug loading and release values were determined using UV/Vis spectroscopy. Amiodarone encapsulated in nanoparticles was completely released at the end of 14 days. About 38 % was released at the end of day 1, 44% released at the end of day 3, 50 % released at the end of day 5 followed slow release. Amiodarone-loaded chitosan nanoparticles could serve as a model for controlled delivery of many antiarrhythmic drugs.

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Section: Resultssupporting

confidence: 87%

Section: Resultssupporting

confidence: 87%

Synthesis of Chitosan Nanoparticles for Controlled Release of Amiodarone

Büyük¹,

Arayıcı²,

Derman³

et al. 2020

ijps

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“…Along the same line, a very recent study designed an inclusion complex of 5-ASA in hydroxypropyl-β-cyclodextrin loaded onto chitosan NPs. This delivery system exhibited a sustained-release profile, and the NPs were more effective than the free drug in inhibiting the secretion of pro-inflammatory cytokine-stimulated colon cancer cells [117]. In another study, polymeric nanoparticles were rectally administered to protect low molecular weight heparin (LMWH) from intestinal degradation and to provide targeted delivery to inflamed tissue in experimental colitis mice.…”

Section: Other Applications Of Nanoparticles For Immune System Modulamentioning

confidence: 99%

Advanced nanomedicines for the treatment of inflammatory diseases

Brusini

Varna

Couvreur

2020

Advanced Drug Delivery Reviews

130

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Inflammation, a common feature of many diseases, is an essential immune response that enables survival and maintains tissue homeostasis. However, in some conditions, the inflammatory process becomes detrimental, contributing to the pathogenesis of a disease. Targeting inflammation by using nanomedicines (i.e. nanoparticles loaded with a therapeutic active principle), either through the recognition of molecules overexpressed onto the surface of activated macrophages or endothelial cells, or through enhanced vasculature permeability, or even through biomimicry, offers a promising solution for the treatment of inflammatory diseases. After providing a brief insight on the pathophysiology of inflammation and current therapeutic strategies, the review will discuss, at a pre-clinical stage, the main innovative nanomedicine approaches that have been proposed in the past five years for the resolution of inflammatory disorders, finally focusing on those currently in clinical trials.

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“…The release reached 100% after 360 min at 50℃, but the maximum release was only 71.2% and 39.6% after 360 min at 35 and 25℃. Tang, Sun, Zhao, Pu, and Zhang et al (2018) reported that release of mesalazine from the mesalazine/hydroxypropyl-β-CD inclusion complex with stability constant of 2162.7 M −1 was about 95% in PBS at 37℃ for 120 min. Comparing to this release of mesalazine, the release of CAT from the CAT/β-CD inclusion complex in PBS medium at 35℃ as shown in Figure 7 was much lower.…”

Section: Release Of Cat From the Cat/β-cd Inclusion Complexmentioning

confidence: 99%

Physicochemical properties of catechin/β-cyclodextrin inclusion complex obtained via co-precipitation

Jiang

Yang

Wang

et al. 2019

CyTA - Journal of Food

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Inclusion complex of catechin (CAT) with β-cyclodextrin (β-CD) was prepared using co-precipitation method to enhance antioxidant stability of CAT and the physicochemical properties of the inclusion complex were studied. The CAT/β-CD inclusion complex was analyzed through phase solubility study, Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and X-ray diffraction (XRD). Phase solubility study indicated that CAT and β-CD formed 1:1 stoichiometric inclusion complex. Results of FT-IR indicated that CAT was stabilized in β-CD cavity by intra-molecular hydrogen bonds. Results of DSC and SEM proved that CAT/β-CD inclusion complex formed. XRD results showed that the formation of new solid crystalline phases in the CAT/β-CD inclusion complex. CAT was effectively protected through encapsulation into β-CD and the antioxidant stability of CAT was improved after encapsulation. In addition, the release behavior of CAT from the inclusion complex increased with increasing of the temperature. Propiedades fisicoquímicas del complejo de inclusión de catequina/β-ciclodextrina obtenido por coprecipitación RESUMEN En el presente estudio se obtuvo el complejo de inclusión de catequina (CAT) con β-ciclodextrina (β-CD) utilizando el método de coprecipitación con el propósito de mejorar la estabilidad antioxidante del CAT. Posteriormente se estudiaron las propiedades fisicoquímicas del complejo de inclusión resultante. Para analizar el complejo de inclusión CAT/β-CD se emplearon los siguientes estudios: estudio de solubilidad de fase, espectroscopia infrarroja transformada de Fourier (FT-IR), calorimetría diferencial de barrido (DSC), microscopía electrónica de barrido (SEM) y difracción de rayos X (DRX). El estudio de solubilidad de fase mostró que el CAT y la β-CD formaron un complejo de inclusión estequiométrica de 1:1. Por su parte, los resultados de FT-IR indicaron que en la cavidad β-CD el CAT fue estabilizado por enlaces de hidrógeno intramoleculares. Los resultados aportados por la DSC y la SEM demostraron que se formó un complejo de inclusión CAT/β-CD. Los resultados de la DRX dieron cuenta de la formación de nuevas fases cristalinas sólidas en el complejo de inclusión CAT/β-CD. El CAT se protegió eficazmente mediante la encapsulación en la β-CD y su estabilidad antioxidante mejoró después de ocurrir la encapsulación. Además, el comportamiento de liberación del CAT a partir del complejo de inclusión se incrementó con el aumento de la temperatura.

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Mesalazine/hydroxypropyl-β-cyclodextrin/chitosan nanoparticles with sustained release and enhanced anti-inflammation activity

Cited by 53 publications

References 30 publications

Synthesis of Chitosan Nanoparticles for Controlled Release of Amiodarone

Synthesis of Chitosan Nanoparticles for Controlled Release of Amiodarone

Advanced nanomedicines for the treatment of inflammatory diseases

Physicochemical properties of catechin/β-cyclodextrin inclusion complex obtained via co-precipitation

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