Meroterpenoids from the Brown Alga Cystoseira usneoides as Potential Anti-Inflammatory and Lung Anticancer Agents

Zbakh, Hanaâ; Zubı́a, Eva; Reyes, Carolina de los; Calderón-Montaño, José Manuel; López‐Lázaro, Miguel; Motilva, Virginia

doi:10.3390/md18040207

Cited by 22 publications

(14 citation statements)

References 64 publications

(75 reference statements)

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“…Increasing evidence suggests that various metabolites from brown seaweeds show anti-inflammatory activities [ 10 , 11 , 12 , 13 ]. Among these, phlorotannins (PTNs) from brown algae, such as Ecklonia cava , have attracted much attention for their clinical applications, including their use as cosmeceuticals [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Topical Application of Phlorotannins from Brown Seaweed Mitigates Radiation Dermatitis in a Mouse Model

et al. 2020

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Radiation dermatitis (RD) is one of the most common side effects of radiotherapy; its symptoms progress from erythema to dry and moist desquamation, leading to the deterioration of the patients’ quality of life. Active metabolites in brown seaweed, including phlorotannins (PTNs), show anti-inflammatory activities; however, their medical use is limited. Here, we investigated the effects of PTNs in a mouse model of RD in vivo. X-rays (36 Gy) were delivered in three fractions to the hind legs of BALB/c mice. Macroscopic RD scoring revealed that PTNs significantly mitigated RD compared with the vehicle control. Histopathological analyses of skin tissues revealed that PTNs decreased epidermal and dermal thickness compared with the vehicle control. Western blotting indicated that PTNs augmented nuclear factor erythroid 2-related factor 2 (NRF2)/heme oxygenase-1 (HO-1) pathway activation but attenuated radiation-induced NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) and inflammasome activation, suggesting the mitigation of acute inflammation in irradiated mouse skin. PTNs also facilitated fast recovery, as indicated by increased aquaporin 3 expression and decreased γH2AX (histone family member X) expression. Our results indicate that topical PTN application may alleviate RD symptoms by suppressing oxidative stress and inflammatory signaling and by promoting the healing process. Therefore, PTNs may show great potential as cosmeceuticals for patients with cancer suffering from radiation-induced inflammatory side effects such as RD.

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Section: Introductionmentioning

confidence: 99%

Topical Application of Phlorotannins from Brown Seaweed Mitigates Radiation Dermatitis in a Mouse Model

et al. 2020

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“…Meroterpenoids Ehrlich's tumor exhibits strong inflammatory phenomena, including edema and inflammatory infiltrates, which are believed to play an essential role in tumor growth in various types of cancer [42,43,44,45,46]. But the anti-inflammatory effects were reported by meroterpenoids [47] and were observed in this research showing that the extract reduces inflammation, reducing the tumor by an indirect route.…”

Section: P Purpurogenum Extract Showed Activity Against Ehrlich's Somentioning

confidence: 58%

Penicillium purpurogenumexerts antitumor effects and ameliorates inflammations in Erlich mice model

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Pontes

Guimarães

et al. 2020

Preprint

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ABSTRACTBackgroundThe bioactive metabolites production contributes to the resistance of fungi towards adverse environmental conditions. Some metabolites often have interesting health-promoting activities. This study addressed the anti-tumoural properties of Penicillium purpurogenum isolated from a polluted lagoon in Northeastern Brazil.MethodsThe extract obtained from the polished environment strain P. purpurogenum was fermented, filtered, concentrated and lyophilized, giving rise to the Ethyl Acetate Extracellular Extract (EAE). The metabolites of the extracellular extract of P. purpurogenum were studied using direct infusion mass spectrometry. The solid Ehrlic tumor model was used to evaluate the extract antitumor activity. Female Swiss mice were divided in groups (n=10/group) as follow: Negative control (CTL-) treated with phosphate buffered solution; Positive Control (CTL+) treated with cyclophosphamide (25mg/mL); Extracts treatment at doses 4, 20 and 100mg/Kg; Animals without tumor or treatment (Sham); and animals without tumor treated with intermediate dose (EAE20). All treatments were performed intraperitoneally, daily during 15 days. After, the animals were eutanized and the tumor, lymphoid organs and serum were used for immunological, histological and biochemical parameters evaluation.ResultsThe extract was rich in meroterpenoids. All doses of the extract significantly reduced tumor size compared to CLT- and were associated with 100% survival. Histologically, the 20 and 100mg/kg doses reduced tumour-associated inflammation and tumour necrosis. The extract also reduced cellular infiltration of lymphoid organs and circulating TNF-α levels when compared with CLT-. The extract did not induce weight loss and renal or hepatic toxic changes.ConclusionsThese results indicate that P. purpurogenum from a polluted marine environment produce hybrid natural products of the terpenoid pathway that exhibits immunomodulatory and antitumor properties in vivo. Thus, fungal fermentation is a biotechnological approach for the production of antitumour agents.

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“…There are new directions in cancer treatment with improved understanding of the correlation among microbes, inflammation, and cancer. For example, meroterpenoids, isolated from the brown seaweed Cystoseira usneoides , significantly reduced the production of TNF-α, IL-6, and IL-1β, suppressed COX-2 expression, and displayed higher cytotoxic activities against lung cancer cells compared with normal lung cells ( 70 ). COX-2 can also enhance gefitinib resistance and NSCLC metastasis via PI3K-AKT silencing, which is a novel therapeutic strategy to overcome gefitinib resistance in NSCLC cells ( 58 ).…”

Section: Microorganisms Inflammation and Cancermentioning

confidence: 99%

Pulmonary Micro-Ecological Changes and Potential Microbial Markers in Lung Cancer Patients

et al. 2021

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The relationship between the microbiome and disease has been investigated for many years. As a highly malignant tumor, biomarkers for lung cancer are diverse. However, precision of these biomarkers has not yet been achieved. It has been confirmed that lung microecology changes in lung cancer patients compared with healthy individuals. Furthermore, the abundance of some bacterial species shows obvious changes, suggesting their potential use as a microbial marker for the detection of lung cancer. In addition, recent studies have confirmed that inflammation, immune response, virulence factors, and metabolism may be potential mechanisms linking the microbiome with carcinogenesis. In this review, microbiome studies of lung cancer, potential mechanisms, potential microbial markers, and the influence of the microbiome on the diagnosis and treatment of lung cancer are summarized, providing theoretical strategies for the diagnosis and treatment of lung cancer.

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Meroterpenoids from the Brown Alga Cystoseira usneoides as Potential Anti-Inflammatory and Lung Anticancer Agents

Cited by 22 publications

References 64 publications

Topical Application of Phlorotannins from Brown Seaweed Mitigates Radiation Dermatitis in a Mouse Model

Topical Application of Phlorotannins from Brown Seaweed Mitigates Radiation Dermatitis in a Mouse Model

Penicillium purpurogenumexerts antitumor effects and ameliorates inflammations in Erlich mice model

Pulmonary Micro-Ecological Changes and Potential Microbial Markers in Lung Cancer Patients

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