Merkel cell polyomavirus and Merkel cell carcinoma

DeCaprio, James A.

doi:10.1098/rstb.2016.0276

Cited by 84 publications

(77 citation statements)

References 119 publications

(142 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Primary infection by polyomavirus is common and has no signs or symptoms. A majority of people become seropositive (40–80%) at an early age . Studies of Merkel cell polyomavirus rates in Australia vary from 23% to 70% .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Trends in the incidence of Merkel cell carcinoma in Victoria, Australia, between 1986 and 2016

et al. 2019

View full text Add to dashboard Cite

Background/Objectives Merkel cell carcinoma (MCC) is a highly invasive cutaneous malignancy. The objective of this study was to investigate the incidence and trends of MCC in Victoria, Australia, between 1986 and 2016. Methods Population‐based, descriptive analysis of Victorian Cancer Registry (VCR) data. The de‐identified records of patients with MCC were obtained from Victoria residents diagnosed between 1986 and 2016. Trends in age‐standardised incidences were examined using joinpoint analysis. Results A total of 1095 cases were found. Incidence of MCC was 3.9 per 100 000 for men and 1.5 per 100 000 for women. The incidence of MCC in men 66–85 is increasing at an annual rate of 4.2% (2.8–5.8%, 95% CI). However, since 2002 the incidence in women in the same age group has been decreasing. Whilst there is an overall stabilisation in the incidence of MCC, incidence of MCC for males is increasing. For MCC in males 85 years old and over, the incidence of MCC was 26.8 per 100 000 between 2012 and 2016. Relative 5‐year survival for patients diagnosed between 2008 and 2012 is 50%. Conclusion Merkel cell carcinoma remains an aggressive cancer, especially among older men. Differences in trends seen in local data can help target preventative and early intervention management strategies in specific groups.

show abstract

Section: Discussionmentioning

confidence: 99%

“…A majority of people become seropositive (40-80%) at an early age. 20 Studies of Merkel cell polyomavirus rates in Australia vary from 23% to 70%. 21,22…”

Section: Discussionmentioning

confidence: 99%

Trends in the incidence of Merkel cell carcinoma in Victoria, Australia, between 1986 and 2016

et al. 2019

View full text Add to dashboard Cite

show abstract

“…MCPyV is the first polyomavirus found to be associated with a human cancer [156,157], and over 80% of Merkel cell carcinomas have been found to harbor viral DNA sequences [156]. Although MCPyV infection is widespread in normal skin, a number of characteristics define it as a probable causative agent: clonal integration of the viral genome into the host cell DNA appears to precede tumor development [158,159]; the tumor cells require persistent expression of the viral small T antigen (sT) to survive [160,161]; and the association with immunesuppression strongly supports a viral etiology for the cancer [158].…”

Section: Merkel Cell Polyomavirusmentioning

confidence: 99%

Upsetting the Balance: When Viruses Manipulate Cell Polarity Control

Thomas

Banks

2018

Journal of Molecular Biology

View full text Add to dashboard Cite

The central importance of cell polarity control is emphasized by the frequency with which it is targeted by many diverse viruses. It is clear that in targeting key polarity control proteins, viruses affect not only host cell polarity, but also influence many cellular processes, including transcription, replication, and innate and acquired immunity. Examination of the interactions of different virus proteins with the cell and its polarity controls during the virus life cycles, and in virally-induced cell transformation shows ever more clearly how intimately all cellular processes are linked to the control of cell polarity.

show abstract

“…We turn to the small human DNA viruses with a review by McBride [25] on HPV, emphasizing the novelties of their replication. DeCaprio [26] describes current understanding on the most recently recognized human tumour virus, Merkel cell polyomavirus (MCV), and other newly discovered human polyomaviruses that have been discovered by sequencing technologies. Liver cancer resulting from HBV and hepatitis C viruses (HCV) infection is an unsolved public health problem despite the success of the HBV vaccine and anti-viral drugs targeting HCV.…”

Section: Introductionmentioning

confidence: 99%

Human oncogenic viruses: nature and discovery

Chang

Moore

Weiss

2017

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

Seven kinds of virus collectively comprise an important cause of cancer, particularly in less developed countries and for people with damaged immune systems. Discovered over the past 54 years, most of these viruses are common infections of humankind for which malignancy is a rare consequence. Various cofactors affect the complex interaction between virus and host and the likelihood of cancer emerging. Although individual human tumour viruses exert their malignant effects in different ways, there are common features that illuminate mechanisms of oncogenesis more generally, whether or not there is a viral aetiology. This article is part of the themed issue ‘Human oncogenic viruses’.

show abstract

Merkel cell polyomavirus and Merkel cell carcinoma

Cited by 84 publications

References 119 publications

Trends in the incidence of Merkel cell carcinoma in Victoria, Australia, between 1986 and 2016

Trends in the incidence of Merkel cell carcinoma in Victoria, Australia, between 1986 and 2016

Upsetting the Balance: When Viruses Manipulate Cell Polarity Control

Human oncogenic viruses: nature and discovery

Contact Info

Product

Resources

About