Merkel cell carcinoma with fibrosarcomatous differentiation

Tan, Kong-Bing; Murali, Rajmohan; Karim, Rooshdiya Z.; Dutta, B.; Dutta, Ruma; McCarthy, Stanley W.; Scolyer, Richard A.

doi:10.1080/00313020701813685

Cited by 20 publications

(4 citation statements)

References 11 publications

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“…Very rarely, MCC may show divergent or composite differentiation. This may be manifest in the form of leiomyosarcoma, 14,15 squamous cell carcinoma, 15,16 fibrosarcoma 17 and rhabdomyosarcoma 6,18 . Herein, we report what is to the best of our knowledge only the third case of MCC with heterologous rhabdomyoblastic differentiation.…”

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confidence: 76%

Merkel cell carcinoma with heterologous rhabdomyoblastic differentiation: the role of immunohistochemistry for Merkel cell polyomavirus large T‐antigen in confirmation

2011

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Merkel cell carcinoma (MCC) represents an uncommon and lethal form of cutaneous malignancy. Historically, the pathogenesis of MCC has been presumed to be linked to ultraviolet light overexposure, but recently, it has been documented that some examples harbor polyomavirus genome, the presence of which is presumed to be of pathogenetic importance. Extremely rare cases of MCC may show heterologous differentiation. We report an example of MCC with heterologous rhabdomyosarcomatous differentiation, the third such case to date, with emphasis on its distinction from fusion-negative alveolar rhabdomyosarcoma. The role of immunohistochemistry for Merkel cell polyomavirus large T-antigen in this differential diagnosis is emphasized.

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confidence: 76%

Merkel cell carcinoma with heterologous rhabdomyoblastic differentiation: the role of immunohistochemistry for Merkel cell polyomavirus large T‐antigen in confirmation

2011

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“…In the present report, all the cases presented both components and approximately 75% of the cases transition. The malignant epithelial components in cutaneous carcinosarcomas comprise SCC, BCC, and malignant adnexal neoplasms including malignant pilomatrixoma, spiradenocarcinoma, and eccrine porocarcinoma, as well as malignant trichoblastoma and Merkel cell tumor 10182526. The mesenchymal component shows histological features of malignancy and consists of spindled and pleomorphic cells showing marked nuclear atypia, necrosis, and numerous atypical mitotic figures.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Carcinosarcoma: a Clinicopathologic and Immunohistochemical Analysis of 11 Korean Cases

et al. 2019

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BackgroundCutaneous carcinosarcoma is a rare biphasic tumor comprising malignant epithelial and heterologous mesenchymal elements. Data on the clinical and histopathologic characteristics of this tumor in Asian populations are not available. The purpose of this study was to investigate the clinicopathologic and immunohistochemical features of cutaneous carcinosarcoma in the Korean population.MethodsWe retrospectively reviewed the records of 11 patients with cutaneous carcinosarcoma who were diagnosed from 2006 to 2016.ResultsThe mean patient age at diagnosis was 71.5 years (range, 43–96 years) and there was a men predilection. The most common site of cutaneous carcinosarcoma was the head and neck (8/11, 72.7%). Histopathologically, most tumors showed a characteristic morphology consisting of two types of tumor cells, varied differentiated epithelial cells (such as basal or squamous cells) and spindle cells with transition zones between the two components. These two cell types also demonstrated variable immunohistochemical characteristics.ConclusionAlthough the number of cases in this study was limited, our results provide valuable insight into the clinical and histopathologic characteristics of cutaneous carcinosarcoma in the Korean population.

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“…In detail, MCCs associated with diverse differentiation patterns have been described: squamous [52], squamous and sarcomatous [53], melanocytic [54], eccrine [55], leiomyosarcomatous [56], rhabdomyoblastic [57], and fibrosarcomatous [58] differentiation. Although there is a certain immunophenotypical diversity in MCs themselves [41], the multitude of differentiation patterns in MCC rather points to stem or early progenitor cells as cells-of-origin.…”

Section: Putative Cells Of Origin For MCCmentioning

confidence: 99%

Which Are the Cells of Origin in Merkel Cell Carcinoma?

Tilling

Moll

2012

Journal of Skin Cancer

119

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Merkel cell carcinoma (MCC), a highly aggressive skin tumour with increasing incidence, is associated with the newly discovered Merkel cell polyomavirus (MCPyV). Studies on MCC and MCPyV as well as other risk factors have significantly increased our knowledge of MCC pathogenesis, but the cells of origin, which could be important targets in future therapies, are still unknown. Merkel cells (MCs), the neuroendocrine cells of the skin, were believed to be at the origin of MCC due to their phenotypic similarities. However, for several reasons, for example, heterogeneous differentiation of MCCs and postmitotic character of MCs, it is not very likely that MCC develops from differentiated MCs. Skin stem cells, probably from the epidermal lineage, are more likely to be cells of origin in MCC. Future studies will have to address these questions more directly in order to identify the physiological cells which are transformed to MCC cells.

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Merkel cell carcinoma with fibrosarcomatous differentiation

Cited by 20 publications

References 11 publications

Merkel cell carcinoma with heterologous rhabdomyoblastic differentiation: the role of immunohistochemistry for Merkel cell polyomavirus large T‐antigen in confirmation

Merkel cell carcinoma with heterologous rhabdomyoblastic differentiation: the role of immunohistochemistry for Merkel cell polyomavirus large T‐antigen in confirmation

Cutaneous Carcinosarcoma: a Clinicopathologic and Immunohistochemical Analysis of 11 Korean Cases

Which Are the Cells of Origin in Merkel Cell Carcinoma?

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