Merkel cell carcinoma of the skin

Nathu, Rakesh M.; Mendenhall, William M.; Parsons, James T.

doi:10.1002/(sici)1520-6823(1998)6:5<233::aid-roi5>3.3.co;2-d

Cited by 4 publications

(4 citation statements)

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“…Attempts that would reduce the rate of loco‐regional metastases would also be capable of improving prognosis. Several uncontrolled studies suggest that MCC should be treated locally aggressively with complete surgical excision and radiotherapy, probably including the loco‐regional lymph nodes 3,21,22,27,31,33–37 . In a study covering 80 MCC patients, relapse‐free survival was 16.5 months in patients with surgery plus radiotherapy, but only 5.5 months after surgery alone 37 .…”

Section: Discussionmentioning

confidence: 99%

“…Several uncontrolled studies suggest that MCC should be treated locally aggressively with complete surgical excision and radiotherapy, probably including the loco-regional lymph nodes. 3,21,22,27,31,[33][34][35][36][37] In a study covering 80 MCC patients, relapse-free survival was 16.5 months in patients with surgery plus radiotherapy, but only 5.5 months after surgery alone. 37 In the present study the median time to recurrence was 11 months, the median overall survival was 25.5 months.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Merkel cell carcinoma – a retrospective analysis of 17 cases

Hohaus¹,

Köstler²,

Schönlebe

et al. 2003

Acad Dermatol Venereol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Merkel cell carcinoma – a retrospective analysis of 17 cases

Hohaus¹,

Köstler²,

Schönlebe

et al. 2003

Acad Dermatol Venereol

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“…Figure 1 shows the distribution of citations. References (Seymour & Mothersill 1997 ; Sheridan et al 1997 ; Desai et al 1998 ; Schmidt-Ullrich et al 1999 ; Smith & Haffty 1999 ; Johnson et al 1998 ; Monga et al 1999 ; Stickle et al 1999 ; Merrick et al 1998 ; Roach et al 1997 ; Wazer et al 1999 ; Joschko et al 1997 ; Chidel et al 1999 ; Durand & Olive 1997 ; Peschel et al 1999 ; Norman et al 1997 ; Kramer et al 1998 ; Leborgne et al 1997 ; Epperly et al 1999 ; Chancy et al 1998 ; Prete et al 1998 ; Fernandez-Vicioso et al 1997 ; Kang & Suh 1999 ; Banasiak et al 1999 ; Nathu et al 1998 ; Haffty et al 1997 ; Gieger et al 1997 ) and Table 1 include the 25 most frequently cited articles (all had at least 30 citations and were published in volumes 5-7, most emanated from the USA). The most frequently cited article in the first 4 volumes achieved 23 citations (Teicher et al 1996 ).…”

Section: Resultsmentioning

confidence: 99%

Scientific impact of studies published in temporarily available radiation oncology journals: a citation analysis

et al. 2015

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The purpose of this study was to review all articles published in two temporarily available radiation oncology journals (Radiation Oncology Investigations, Journal of Radiosurgery) in order to evaluate their scientific impact. From several potential measures of impact and relevance of research, we selected article citation rate because landmark or practice-changing research is likely to be cited frequently. The citation database Scopus was used to analyse number of citations. During the time period 1996-1999 the journal Radiation Oncology Investigations published 205 articles, which achieved a median number of 6 citations (range 0-116). However, the most frequently cited article in the first 4 volumes achieved only 23 citations. The Journal of Radiosurgery published only 31 articles, all in the year 1999, which achieved a median number of 1 citation (range 0-11). No prospective randomized studies or phase I-II collaborative group trials were published in these journals. Apparently, the Journal of Radiosurgery acquired relatively few manuscripts that were interesting and important enough to impact clinical practice. Radiation Oncology Investigations’ citation pattern was better and closer related to that reported in several previous studies focusing on the field of radiation oncology. The vast majority of articles published in temporarily available radiation oncology journals had limited clinical impact and achieved few citations. Highly influential research was unlikely to be submitted during the initial phase of establishing new radiation oncology journals.

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“…Patients affected by Merkel cell tumor can be classified into three different groups: stage I, with localized disease; stage II, with regional lymph node metastases, and stage III with systemic disease. In these different stages, survival ranges from a 5-year period in 38-50% of cases for stage I 36 • 37 (surgery of the primitive lesion in association with radiotherapy, 40-60 Gy) 15 • 38 -47 , with local control in 73% of cases 36 , to a 5-year survival in fewer than 50% of cases for stage 11 37 .4 8 .4 9 , in which excision of the primitive lesion is associated with regional lymphadenectomy and radiotherapy. In stage III, chemotherapy shows a surprising objective response from the beginning of treatment (61 %), with a progressive drop after a second ( 45%) and a third line of therapy (20% ) 50 , with a very short duration, from 3.5 to 12 months 51 (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Clinical Experience on Eight Cases of Merkel Cell Carcinoma

Cirillo

Buononato²,

Lima³

et al. 2003

Tumori

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Merkel cell carcinoma is a rare neuroendocrine neoplasm of the skin. The tumor most frequently affects elderly patients, with a preference for the head and neck. Eight patients affected by Merkel cell carcinoma have been observed at the General Surgery Unit II of the "Istituti Ospitalieri" hospital in Cremona, each in different stages of the disease; 75% of the cases involved the extremities, and in nearly all of the cases the tumor was nodular in appearance, with an average diameter of 2.2 cm. In 2 cases, the tumor was associated with rheumatoid arthritis, suggesting a dependency on the part of the neoplasm on the immune disorder and on steroid treatment. The available data confirm that in stage I of the disease, surgical treatment should be associated with radiotherapy in order to control the development of local relapses or metastases over time. In this stage, we observed a survival of 34 months (range, 24-48). In stages II and III, survival time falls, with very short duration of responses and poor quality of life as a result of the administration of cytotoxic molecules. Bearing in mind that any local relapse tends to appear within 12 months of the removal of the primitive tumor, that lymph node metastases appear in almost half of the patients, and that metastases over time are manifested in over a third of patients, it is essential to adopt a treatment capable of balancing the demand for longer remissions with a better quality of life. In this situation, we observed that treatment with somatostatin analogues achieves interesting responses without side effects, which suggests a close biological relationship between the tumor and somatostatin and that making a careful assessment of the prognostic factors of the disease can guarantee a correct therapeutic choice.

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Merkel cell carcinoma of the skin

Cited by 4 publications

References 0 publications

Merkel cell carcinoma – a retrospective analysis of 17 cases

Merkel cell carcinoma – a retrospective analysis of 17 cases

Scientific impact of studies published in temporarily available radiation oncology journals: a citation analysis

Clinical Experience on Eight Cases of Merkel Cell Carcinoma

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