Merkel-cell Carcinoma in Behçet's Disease

The Etiology and Epidemiology of Merkel Cell Carcinoma

“…[41][42][43][44][45][46][48][49][50] Partial regression of metastatic MCC has been reported after discontinuation of immunosuppressive therapy. 51,52 MCC has been reported to occur after transplantation of the kidney, liver, heart, and bone marrow; however, most reported cases are in kidney transplant patients.…”

“…Cases of MCC have been observed in almost every autoimmune disease [41][42][43][44][45][46][47] and they have been increasing in frequency in the last decade with the introduction of potent immunosuppressant drugs in the treatment of these diseases. [41][42][43][44][45][46][48][49][50] Partial regression of metastatic MCC has been reported after discontinuation of immunosuppressive therapy.…”

Squamous Cell Carcinoma in a Chronic Genital Ulcer in Behçet’s Disease

“…To the best of our knowledge, only one such case has been reported, in which a patient with BD subsequently developed a Merkel cell carcinoma on the left forearm (2). The authors ofthat report suggested that immunosuppression due to the treatment for BD might have triggered the Merkel cell carcinoma, although the occurrence of BD with solid tumours tends to be regarded as coincidental.…”

Malignant lymphoma associated with Behçet’s disease: A report of 2 cases

“…Numerous studies report that CVD predisposes patients to increased toxicity from therapeutic irradiation [34][35][36][37][38]; however, considering the effects of RT in patients with BD, the literature is lacking sufficient data, as there are only a few reports on the use of radiation in BD patients. In a part of these reports, the authors had not been referred to radiation toxicity [16,18,20,39]. Lowdose total lymphoid irradiation treatment in 5 patients with intractable BD was reported; no morbidity related to irradiation occurred, presumably because of the relatively low doses used [13].…”