Squamous Cell Carcinoma in a Chronic Genital Ulcer in Behçet’s Disease

Hata, Hiroo; Aoyagi, Satoka; Iitani, Maria Maroto; Homma, Erina; Shimizu, Hiroshi

doi:10.2340/00015555-0902

Cited by 4 publications

(3 citation statements)

References 3 publications

(1 reference statement)

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“…In general, malignancy caused by BD is rare. In a recent paper, a squamous cell carcinoma in a chronic genital ulcer has been reported in a female patient with BD [10]. For these reasons, it might be expected that the disease may lead to abnormal cervical or vaginal epithelial changes.…”

Section: Introductionmentioning

confidence: 96%

Evaluation of patients with Behçet’s disease by cervical cytology and colposcopic examination

Özdemir

Çelık

et al. 2011

Arch Gynecol Obstet

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Section: Introductionmentioning

confidence: 96%

Evaluation of patients with Behçet’s disease by cervical cytology and colposcopic examination

Özdemir

Çelık

et al. 2011

Arch Gynecol Obstet

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“…Genital ulcerations are usually painful and develop around the anus, vulva, or scrotum, and may be at the origin of scar formation. Coexistence of BD and malignant tumors is rare [ 1 ], but association with genital neoplasms has been described in previous reports [ 2 ]. To the best of our knowledge, the association between BD and vulvar intraepithelial neoplasia grade 3 (VIN3) has not yet been described in the literature.…”

Section: Introductionmentioning

confidence: 99%

Vulvar intraepithelial neoplasia grade 3 associated with Behçet’s disease

et al. 2016

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BackgroundLittle information is available regarding the association between vulvar intraepithelial neoplasia grade 3 (VIN3) and Behçet’s disease (BD). We report here concomitant VIN3 and genital ulcers in a patient with BD.CaseA 44-year-old Caucasian woman with a history of BD, which had been evolving for 6 years, presented with ulcerated and papillomatous lesions on the vulva. Biopsies revealed a multifocal VIN3 positive for high-risk human papillomavirus (HPV) 33. Multiple biopsies were performed to exclude invasive cancer and VIN3 was treated with laser vaporization.ConclusionWe report clinical and anatomopathological features of a rare case of multifocal, high-risk, HPV-related VIN3. We also discuss the possible pathogenesis in the context of BD, featuring chronic ulceration and intrinsic or treatment-induced immunosuppression.

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“…In situ SCC development on a chronic vulvar ulcer of a female patient with BD was previously reported. The authors had pointed out that long-term systemic corticosteroid treatment could contribute to the development of SCC in this genital ulcer, which was resistant to treatment3. Satolli et al4 reported a Merkel cell carcinoma in a patient with BD, and mentioned that the immunosuppresives may lead to the development of cancer.…”

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confidence: 99%