Merkel Cell Carcinoma As a Solitary Metastasis to the Testis

Whitman, Eric J.; Brassell, Stephen A.; Rosner, Inger L.; Moncur, Joel T.

doi:10.1200/jco.2007.12.3091

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…MCC metastasizing to the testis is rare. To date, there are seven cases of testicular MCC published in the literature [8–13]. Clinical details of all cases are summarized in Additional file 1: Table S1.…”

Section: Introductionmentioning

confidence: 99%

Recurrent Merkel cell carcinoma of the testis with unknown primary site: a case report

2016

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BackgroundMerkel cell carcinoma is a rare and aggressive neuroendocrine tumor that commonly arises in the skin. It is rare for it to occur in the testes. There are only seven cases of testicular Merkel cell carcinoma reported in the literature.Case presentationA 66-year-old Maori man presented to our hospital with left testicular swelling. His alpha-fetoprotein and beta-human chorionic gonadotrophin levels were within normal limits. His lactate dehydrogenase concentration was elevated to 267 U/L. Ultrasound imaging confirmed a large testicular mass, and he underwent left orchiectomy. His histological examination revealed a neuroendocrine tumor with an immunostaining pattern suggesting Merkel cell carcinoma. He presented to our hospital again 3 months later with right testicular swelling that was confirmed on ultrasound sonography to be a tumor. He underwent a right orchiectomy, and his histological examination revealed metastatic Merkel cell carcinoma. A primary lesion was not identified, and computed tomographic imaging did not reveal spread to other organs. He received six cycles of adjuvant carboplatin and etoposide chemotherapy and remained disease-free 18 months after completion of chemotherapy.ConclusionsGiven the paucity of studies, standard adjuvant treatment for testicular Merkel cell carcinoma remains uncertain, although platinum-based chemotherapy seems to be an appropriate option.Electronic supplementary materialThe online version of this article (doi:10.1186/s13256-016-1102-5) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Recurrent Merkel cell carcinoma of the testis with unknown primary site: a case report

2016

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“…Neither included in the imaging workup. 4 All reported cases were, indeed, detected in the presence of symptomatic enlargement of the testis, except in one case in which metastatic dissemination was depicted in both testes by somatostatin receptor scintigraphy.…”

Section: Discussionmentioning

confidence: 92%

“…Specifically, to date, only eight cases of MCC metastatic to the testis were reported in the literature (Table 2), our report is the ninth case. [3][4][5][6][7][8][9] Metastasis to the genital tract is accessible for curative surgical excision. It may be overlooked since the external genitalia is not routinely examined in the MCC surveillance.…”

Section: Discussionmentioning

confidence: 99%