Merkel cell carcinoma metastatic to the testis: report of a rare diagnosis and review of the literature

Gigliano, Davide; Lobo, João; Lopes, Paula; Julião, Ivo; Lobo, Francisco; Azevedo, Rosa; Henrique, Rui; Rodrigues, Ângelo

doi:10.4322/acr.2020.198

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…The liver, bone, lung, brain, adrenal gland, and skin are common sites of distant metastasis, although metastasis to the genitourinary system is uncommon [2]. Merkel cell carcinoma metastasis to the testes is an extremely rare event, with just 11 cases reported in the medical literature [5][6][7][8][9][10][11][12][13][14]. On imaging, it is difficult to differentiate MCC metastasis from other testicular neoplasms such as primary testicular tumors, synchronous undetected small cell lung cancer, lymphomas, or anaplastic small cell melanomas.…”

Section: Discussionmentioning

confidence: 99%

“…Testicular metastasis is extremely uncommon, accounting for just a small fraction of cases documented in the literature [4]. There have only been 11 recorded cases of MCC metastasizing to the testis in the literature [5][6][7][8][9][10][11][12][13][14]. In this report, we present the 12th case and provide a comprehensive review of the existing literature.…”

Section: Introductionmentioning

confidence: 91%

See 1 more Smart Citation

Merkel Cell Carcinoma of the Left Cheek With Testicular Metastasis: An Uncommon Occurrence

Suthar,

Marathu,

Singh

et al. 2023

Cureus

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Merkel cell carcinoma (MCC) is an infrequent and aggressive neuroendocrine tumor of the skin. 18Ffluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is an effective imaging technique with good diagnostic accuracy that may be used to help stage MCC and for detecting unexpected recurrences and distant metastatic disease. Other causes of testicular neoplasms, such as primary testicular tumors, lymphomas, or anaplastic small cell melanomas, are difficult to differentiate from MCC testicular metastases on imaging, and tumor markers and histopathology will help confirm it. The current case is a 65-year-old non-immunocompromised male with Merkel cell carcinoma who was incidentally identified with testicular metastases on PET/CT and confirmed on histopathology.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

Merkel Cell Carcinoma of the Left Cheek With Testicular Metastasis: An Uncommon Occurrence

Suthar,

Marathu,

Singh

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…Testis is a very rare metastatic site from MCC [2][3][4][5][6]. In a recent review [6], only eleven cases of testicular MCC metastases are reported in literature.…”

Section: To the Editormentioning

confidence: 99%

Merkel Cell Carcinoma: Mind The Genital Metastatic Sites!

Santandrea,

Borsari,

Filice

et al. 2023

Dermatol Pract Concept

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Metachronous Testicular Metastases from Merkel Cell Carcinoma (MCC): A Case Report and Literature Review

et al. 2022

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Patient: Male, 57-year-old Final Diagnosis: Merkel cell carcinoma (MCC) • testicular metastasis Symptoms: Enlargement of testes due to MCC metastases Medication: — Clinical Procedure:— Specialty: Oncology Objective: Rare disease Background: Merkel cell carcinoma (MCC) is a rare neuroendocrine neoplasm. The immunotherapy era has dramatically changed MCC prognosis, but unresponsive and progressive diseases after anti- programmed death-ligand 1 (PDL1) treatment still represent a challenge. MCC can metastasize in virtually every anatomical site, also during immunotherapy, and the reasons for primary resistance are debated. Testes are a rare metastatic site, accounting only 0.04% of autoptic detections in patients with more common malignancies. We report a case of a patient with metachronous and bilateral testes metastases after a previous radically treated MCC. Case Report: A 57-year-old man underwent radical surgery for left knee MCC. The oncologic follow-up was negative until 4 years later when the patient developed a right testis lesion. The patient underwent right orchiectomy for the suspicion of testicular primary malignancy, but the pathologist report revealed MCC metastasis. Subsequent radiologic assessment detected new bone metastases. The patient was treated with immunotherapy, experiencing a complete response. After 20 months of treatment, a further assessment revealed a new single left testis metastasis. A left orchiectomy was performed and immunotherapy was continued, maintaining a complete response. Conclusions: There are few reports that MCC can be associated with uncommon metastases in testicular tissue. The present case suggests the testis represents another “sanctuary” site for the metastasizing process and host immune response. Considering the dramatic impact of immunotherapy in MCC prognosis, the study of these rare cases may aid the understanding of intrinsic resistance mechanisms to anti-PDL1, which affects a percentage of MCC patients.

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Merkel cell carcinoma metastatic to the testis: report of a rare diagnosis and review of the literature

Cited by 3 publications

References 14 publications

Merkel Cell Carcinoma of the Left Cheek With Testicular Metastasis: An Uncommon Occurrence

Merkel Cell Carcinoma of the Left Cheek With Testicular Metastasis: An Uncommon Occurrence

Merkel Cell Carcinoma: Mind The Genital Metastatic Sites!

Metachronous Testicular Metastases from Merkel Cell Carcinoma (MCC): A Case Report and Literature Review

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