Merging Helicobacter pylori eradication and family history-based genetic counseling in patients with gastric cancer: towards an overarching approach in clinical practice

Mentis, Alexios‐Fotios A.; Rokkas, Theodore

doi:10.20524/aog.2021.0589

Cited by 1 publication

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 11 On the other hand, some reports suggest that H. pylori infection can be acquired from siblings, mainly from older siblings to younger siblings. 12 , 13 However, few studies on the relationship of H. pylori strains between families and members use molecular genotyping techniques. 10 , 14 Therefore, this intrafamilial transmission of H. pylori could contribute to the exchange and persistence of pathogenic strains associated with developing associated diseases.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Oral Helicobacter pylori Infection in an Indigenous Community in Southwest Mexico

Urrutia-Baca,

Gonzalez Brosig,

Salazar-Garza

et al. 2023

CEG

View full text Add to dashboard Cite

Purpose Epidemiological studies have been conducted to improve the health and economic quality of life of indigenous communities in Mexico. These studies have found that infections cause frequent health problems. Helicobacter pylori are responsible for conditions ranging from gastritis to stomach cancer. This study determined the prevalence of H. pylori in families from Siltepec, Chiapas, Mexico. Patient and Methods Ninety-nine dental plaque samples from 36 families were studied. Real-time PCR was performed to detect H. pylori using previously reported primers. The Mann–Whitney U -test was used for the statistical analysis. According to the family role of H. pylori -positive individuals, the VacA s1/m1 genotype and CagA gene correlated. Results The mother had the highest expression of VacA s1/m1-/cagA- with 19% (8/42), followed by the first child with 14.3% (6/42). The major roles for the vacA s1/m1+/cagA- were the mother and first child with 9.5% (4/42), followed by the remaining children with 4.8% (2/42). The vacA s1/m1-/cagA+ genotype was 7.1% (3/42) for the mother and 4.8% (2/42) for the father. Finally, the vacA s1/m1+/cagA+ genotype only appeared in the mother, son I, and son III with 2.4% (1/42). Conclusion The vacA s1/m1/cagA genotypes predominated in the mother, suggesting potential transmission between the mother and child during the first years of life.

show abstract