Prevalence of Oral Helicobacter pylori Infection in an Indigenous Community in Southwest Mexico

Abstract

Purpose Epidemiological studies have been conducted to improve the health and economic quality of life of indigenous communities in Mexico. These studies have found that infections cause frequent health problems. Helicobacter pylori are responsible for conditions ranging from gastritis to stomach cancer. This study determined the prevalence of H. pylori in families from Siltepec, Chiapas, Mexico. Patient and Methods Ninety-nine dental plaque samples from 36 families were studied. Real-time PCR was performed to detect H. pylori using previously reported primers. The Mann–Whitney U -test was used for the statistical analysis. According to the family role of H. pylori -positive individuals, the VacA s1/m1 genotype and CagA gene correlated. Results The mother had the highest expression of VacA s1/m1-/cagA- with 19% (8/42), followed by the first child with 14.3% (6/42). The major roles for the vacA s1/m1+/cagA- were the mother and first child with 9.5% (4/42), followed by the remaining children with 4.8% (2/42). The vacA s1/m1-/cagA+ genotype was 7.1% (3/42) for the mother and 4.8% (2/42) for the father. Finally, the vacA s1/m1+/cagA+ genotype only appeared in the mother, son I, and son III with 2.4% (1/42). Conclusion The vacA s1/m1/cagA genotypes predominated in the mother, suggesting potential transmission between the mother and child during the first years of life.

Novel therapeutic regimens against Helicobacter pylori: an updated systematic review

“…Willems et al reported that the H. pylori infection rate in Canada was approximately 20–30% ( Willems et al, 2020 ). Victor et al collected dental plaque samples from 36 families in a southwestern Mexican community and reported an H. pylori infection rate of 41.7% ( Urrutia-Baca et al, 2023 ). In a urease test report from Brazil, involving 852 individuals, the overall H. pylori infection rate was 35.4%, with a specific infection rate of 24.7% among children and adolescents ( Toscano et al, 2018 ).…”