Mercury levels assessment and its relationship with oxidative stress biomarkers in children from three localities in Yucatan, Mexico

Rangel-Méndez, Jorge Aarón; Árcega-Cabrera, Flor; Fargher, Lane F.; Moo-Puc, Rosa

doi:10.1016/j.scitotenv.2015.10.152

Cited by 12 publications

(8 citation statements)

References 46 publications

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“…MeHg enters the food web through the consumption of the Hg-converting bacteria by zooplankton [7], and is strongly biomagnified accumulating at high levels in large predatory fishes and other top predators including humans [8]. Previous observations have demonstrated dramatic impacts on phenotypes and health from Hg exposures in a variety of species, including humans [9, 10]. The zebrafish is a powerful model of human development and disease due its similar physiological, morphological, and genetic characteristics with humans [11].…”

Section: Introductionmentioning

confidence: 99%

Mercury-induced epigenetic transgenerational inheritance of abnormal neurobehavior is correlated with sperm epimutations in zebrafish

et al. 2017

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Methylmercury (MeHg) is a ubiquitous environmental neurotoxicant, with human exposures predominantly resulting from fish consumption. Developmental exposure of zebrafish to MeHg is known to alter their neurobehavior. The current study investigated the direct exposure and transgenerational effects of MeHg, at tissue doses similar to those detected in exposed human populations, on sperm epimutations (i.e., differential DNA methylation regions [DMRs]) and neurobehavior (i.e., visual startle and spontaneous locomotion) in zebrafish, an established human health model. F0 generation embryos were exposed to MeHg (0, 1, 3, 10, 30, and 100 nM) for 24 hours ex vivo. F0 generation control and MeHg-exposed lineages were reared to adults and bred to yield the F1 generation, which was subsequently bred to the F2 generation. Direct exposure (F0 generation) and transgenerational actions (F2 generation) were then evaluated. Hyperactivity and visual deficit were observed in the unexposed descendants (F2 generation) of the MeHg-exposed lineage compared to control. An increase in F2 generation sperm epimutations was observed relative to the F0 generation. Investigation of the DMRs in the F2 generation MeHg-exposed lineage sperm revealed associated genes in the neuroactive ligand-receptor interaction and actin-cytoskeleton pathways being effected, which correlate to the observed neurobehavioral phenotypes. Developmental MeHg-induced epigenetic transgenerational inheritance of abnormal neurobehavior is correlated with sperm epimutations in F2 generation adult zebrafish. Therefore, mercury can promote the epigenetic transgenerational inheritance of disease in zebrafish, which significantly impacts its environmental health considerations in all species including humans.

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Section: Introductionmentioning

confidence: 99%

Mercury-induced epigenetic transgenerational inheritance of abnormal neurobehavior is correlated with sperm epimutations in zebrafish

et al. 2017

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“…In previous work, we demonstrated that the binding of Hg 2+ to proteins with molecular weights between the ranges of 20–30 kDa induces the opening of a non‐specific pore (Chávez and Holguín, ). In addition, Hg 2+ has been involved in triggering oxidative stress (Rangel‐Méndez et al, ). At the subcellular level, oxidative stress induces kidney mitochondrial damage.…”

Section: Resultsmentioning

confidence: 99%

CDP‐choline circumvents mercury‐induced mitochondrial damage and renal dysfunction

Buelna‐Chontal

Franco

Hernández‐Esquivel

et al. 2017

Cell Biology International

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Heavy metal ions are known to produce harmful alterations on kidney function. Specifically, the accumulation of Hg in kidney tissue may induce renal failure. In this work, the protective effect of CDP-choline against the deleterious effects induced by Hg on renal function was studied. CDP-choline administered ip at a dose of 125 mg/kg body weight prevented the damage induced by Hg administration at a dose of 3 mg/kg body weight. The findings indicate that CDP-choline guards mitochondria against Hg -toxicity by preserving their ability to retain matrix content, such as accumulated Ca . This nucleotide also protected mitochondria from Hg -induced loss of the transmembrane electric gradient and from the generation of hydrogen peroxide and membrane TBARS. In addition, CDP-choline avoided the oxidative damage of mtDNA and inhibited the release of the interleukins IL-1 and IL6, recognized as markers of acute inflammatory reaction. After the administration of Hg and CDP, CDP-choline maintained nearly normal levels of renal function and creatinine clearance, as well as blood urea nitrogen (BUN) and serum creatinine.

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“…Studies have investigated the association between Hg exposure and oxidative stress in human adult populations that present high frequencies of fish consumption [13,19], but few studies discussing this relationship in children groups are available [20]. Due to their differentiated and easily alterable metabolism, children are a subgroup with specific vulnerabilities to toxic substances present in the environment [21,22]).…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress Levels Induced by Mercury Exposure in Amazon Juvenile Populations in Brazil

Carvalho

Hacon

Vega

et al. 2019

IJERPH

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Oxidative stress can be induced by mercury (Hg) exposure, including through fish consumption (diet), leading to health risks. The objective of this study was to evaluate the association between oxidative stress biomarkers and dietary Hg exposure levels in riverine children and adoluiaescents at Madeira River (RO/Brazil). Population from three riverine local communities presenting different fish consumption frequencies was sampled. Hg was determined in blood (ICP-MS) and glutathione (GSH); glutathione S-transferases (GST) and malondialdehyde (MDA) were determined in serum (spectrophotometry). Statistical analyses were performed using parametric and non-parametric tests. Multiple linear regression models and generalized additives models were also used to estimate the relationships between oxidative stress biomarkers and blood Hg. The juvenile riverine population from Cuniã RESEX presented the highest levels of oxidative stress and Hg levels in blood (GST = 27.2 (4.93) U/L, MDA = 1.69 (0.27) µmol/L, Hg = 20.6 (18.0) µg/L). This population also presented the highest frequency of fish consumption. The positive relation between Hg and GST and MDA, adjusted for individual characteristics, suggests an oxidative effect. This study shows the importance of oxidative stress biomarkers in the evaluation of dietary Hg exposure since initial and reversible metabolic changes were observed, enriching health risk assessments.

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Mercury levels assessment and its relationship with oxidative stress biomarkers in children from three localities in Yucatan, Mexico

Cited by 12 publications

References 46 publications

Mercury-induced epigenetic transgenerational inheritance of abnormal neurobehavior is correlated with sperm epimutations in zebrafish

Mercury-induced epigenetic transgenerational inheritance of abnormal neurobehavior is correlated with sperm epimutations in zebrafish

CDP‐choline circumvents mercury‐induced mitochondrial damage and renal dysfunction

Oxidative Stress Levels Induced by Mercury Exposure in Amazon Juvenile Populations in Brazil

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