Merck’s Reagenzien-Verzeichnis

Merck, E.

doi:10.1007/978-3-662-38287-5

Cited by 11 publications

(8 citation statements)

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“…In one experiment, a very small amount of solid was isolated, but this proved to be the allophanate of I. The other method, which is claimed to be successful with simple tertiary alcohols (5), involves conversion of the carbinol to its chloroformic ester with phosgene at low temperature and in the presence of a tertiary amine, followed by treatment of the chloroformate with ammonia. In numerous experiments this method was applied to I and to related carbinols.…”

Section: Ch Ohmentioning

confidence: 99%

Hypnotics and Anticonvulsants. Iii. Carbamates of Tertiary Acetylenic Carbinols

McLamore¹,

Pan²,

Bavley³

1955

J. Org. Chem.

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Section: Ch Ohmentioning

confidence: 99%

Hypnotics and Anticonvulsants. Iii. Carbamates of Tertiary Acetylenic Carbinols

McLamore¹,

Pan²,

Bavley³

1955

J. Org. Chem.

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“…He published his reaction in England [6], and in Germany, [7]. His test was registered in analytical records in the United States [8], and in Germany [9].…”

Section: Antecedentsmentioning

confidence: 99%

On the mechanism of the Tattersall test for morphine

Francisco¹,

Gómez²

2023

Magna Sci. Adv. Res. Rev.

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Being morphine a restricted drug, a rapid colour test for its detection is very useful. Tattersall employed as reagent trisodium ortho-arsenate in sulphuric acid. However, the more common disodiumhydrogen ortho-arsenate heptahydrate can be used also because both salts yield the same reactive species, that is, protonated arsenic acid and a cation with arsenic(IV). An arsenate is formed with the phenolic group in morphine. Dehydration of this organometallic ester yields a cationic intermediate that induces reaction with arsenic acid at ortho-position (electromeric effect), and a concerted mechanism takes place. A dienone is formed and there is elimination of meta-arsenous acid. Aromatization followed by acidolysis of the new arsenate gives water, meta-arsenous acid, and morphine ortho-quinone, via a six-member concerted mechanism. The colours observed in the test are due to halochromism.

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“…The Prescription Drug User Fee Act date was set for January 20, 2021. 19 Vericiguat was approved by the FDA on January 19, 2021. 20 Vericiguat is available as 2.5, 5, and 10 mg tablets.…”

Section: Contraindications Warnings and Precautionsmentioning

confidence: 99%

Vericiguat

Nguyen

Baker

2021

Hosp Pharm

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Merck’s Reagenzien-Verzeichnis

Cited by 11 publications

References 0 publications

Hypnotics and Anticonvulsants. Iii. Carbamates of Tertiary Acetylenic Carbinols

Hypnotics and Anticonvulsants. Iii. Carbamates of Tertiary Acetylenic Carbinols

On the mechanism of the Tattersall test for morphine

Vericiguat

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