Meranzin hydrate elicits antidepressant effects and restores reward circuitry

Liu, Xiangfei; Zhang, Tian; Chen, Ken; Xu, Minhui; Wu, Lei; Liu, Jin; Huang, Yunke; Nie, Binbin; Shen, Xu; Ren, Peiyu; Huang, Xi

doi:10.1016/j.bbr.2020.112898

Cited by 12 publications

(6 citation statements)

References 56 publications

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“…Other researchers have reported that naringin exhibited bone regeneration, anti-inflammatory, and anticancer effects . Moreover, some pharmacological research demonstrated that meranzin hydrate possessed anti-anxiety and anti-depressant effects …”

Section: Resultsmentioning

confidence: 99%

“… 22 Moreover, some pharmacological research demonstrated that meranzin hydrate possessed anti-anxiety and anti-depressant effects. 23 …”

Section: Resultsmentioning

confidence: 99%

“…22 Moreover, some pharmacological research demonstrated that meranzin hydrate possessed antianxiety and anti-depressant effects. 23 The contents of the above-mentioned 6 nonvolatile compounds were different in 12 batches of pomelo peels, suggesting differences among cultivars and origins. The quantification results were compared and displayed with a heatmap (Figure 6).…”

Section: Simultaneous Quantification Of Six Bioactivementioning

confidence: 98%

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Qualitative and Quantitative Analyses of the Chemical Components of Peels from Different Pomelo Cultivars (Citrus grandis [L.] Osbeck) Based on Gas Chromatography–Mass Spectrometry, Ultraperformance Liquid Chromatography-Q-Exactive Orbitrap-MS, and High-Performance Liquid Chromatography-Photodiode Array Detection

Tian

Wang

et al. 2023

ACS Omega

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The volatile and nonvolatile phytochemicals in peels of 5 major pomelo cultivars (including Citrus grandis cv. Yuhuanyou, C. grandis cv. Liangpingyou, C. grandis cv. Guanximiyou, C. grandis cv. Duweiwendanyou, and C. grandis cv. Shatianyou) from 11 places in China were characterized. First, 194 volatile compounds in pomelo peels were identified by gas chromatography−mass spectrometry (GC−MS). Of these, 20 major volatile compounds were subjected to cluster analysis. The heatmap indicated that the volatile compounds in peels of C. grandis cv. Shatianyou and C. grandis cv. Liangpingyou were different from those in other varieties, while there was no difference among C. grandis cv. Guanximiyou, C. grandis cv. Yuhuanyou, and C. grandis cv. Duweiwendanyou from different origins. Second, 53 nonvolatile compounds were identified in pomelo peels by ultraperformance liquid chromatography-Q-exactive orbitrap tandem MS (UPLC-Q-exactive orbitrap-MS), of which 11 components were detected for the first time. Third, six major nonvolatile compounds were quantitatively analyzed with high-performance LC-photodiode array detection (HPLC-PDA). Combining the results of HPLC-PDA and the heatmap, 6 nonvolatile compounds in 12 batches of pomelo peel were well separated among varieties. Comprehensive analysis and identification of chemical components in pomelo peels are of great significance for their further development and utilization.

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Section: Resultsmentioning

confidence: 99%

“… 22 Moreover, some pharmacological research demonstrated that meranzin hydrate possessed anti-anxiety and anti-depressant effects. 23 …”

Section: Resultsmentioning

confidence: 99%

Section: Simultaneous Quantification Of Six Bioactivementioning

confidence: 98%

See 1 more Smart Citation

Qualitative and Quantitative Analyses of the Chemical Components of Peels from Different Pomelo Cultivars (Citrus grandis [L.] Osbeck) Based on Gas Chromatography–Mass Spectrometry, Ultraperformance Liquid Chromatography-Q-Exactive Orbitrap-MS, and High-Performance Liquid Chromatography-Photodiode Array Detection

Tian

Wang

et al. 2023

ACS Omega

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“…This prescription is composed with five herbs, including Aurantii fructus immaturus, Allii macrostemonis bulbus, Trichosanthis fructus, Magnoliae officinalis cortex, and Cinnamomi ramulus and has therapeutic efficacy with chest stuffiness. Modern pharmacological research revealed that A. fructus immaturus has pharmacological effects related to CVD via prolonging myocardial blood perfusion time to reduce myocardial ischemic response . A. macrostemonis bulbus and T. fructus are the principal herbs of ZXGD, and modern pharmacology has proved that A. macrostemonis bulbus can significantly reduce the contents of serum total cholesterol, low-density lipoprotein cholesterol, triglyceride level, and atherosclerosis thickness in hyperlipidemic rats.…”

Section: Introductionmentioning

confidence: 99%

“…Modern pharmacological research revealed that A. fructus immaturus has pharmacological effects related to CVD via prolonging myocardial blood perfusion time to reduce myocardial ischemic response. 10 A. macrostemonis bulbus and T. fructus are the principal herbs of ZXGD, and modern pharmacology has proved that A. macrostemonis bulbus can significantly reduce the contents of serum total cholesterol, low-density lipoprotein cholesterol, triglyceride level, and atherosclerosis thickness in hyperlipidemic rats. Meanwhile, T. fructus has many functions, such as dilating microvessels, increasing coronary blood flow, increasing hypoxia tolerance, protecting ischemic myocardium, and so on.…”

Section: Introductionmentioning

confidence: 99%

Study on the Active Constituents and Molecular Mechanism of Zhishi Xiebai Guizhi Decoction in the Treatment of CHD Based on UPLC-UESI-Q Exactive Focus, Gene Expression Profiling, Network Pharmacology, and Experimental Validation

Liu

et al. 2022

ACS Omega

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As one of the most common clinical cardiovascular diseases (CVDs), coronary heart disease (CHD) is the most common cause of death in the world. It has been confirmed that Zhishi Xiebai Guizhi decoction (ZXGD), a classical prescription of the traditional Chinese medicine (TCM), has achieved certain effects in the treatment of CHD; however, the mechanism still remains controversial. In this paper, an integrated approach, including UPLC-UESI-Q Exactive Focus, gene expression profiling, network pharmacology, and experimental validation, was introduced to systematically investigate the mechanism of ZXGD in the treatment of CHD. First, UPLC-UESI-Q Exactive Focus was applied to identify the chemical compounds of ZXGD. Then, the targets of the components for ZXGD were predicted by MedChem Studio software embed in the integrative pharmacology-based research platform of TCM, and the differentially expressed genes (DEGs) of CHD were obtained by gene expression profiling in gene expression omnibus database. The common genes of the above two genes were obtained by Venn analysis as the targets of GXGD in treatment with CHD. Third, the core targets were screened out by protein–protein interaction network analysis, and the kyoto encyclopedia of genes and genomes pathway enrichment analysis was performed by the database for annotation, visualization, and integrated discovery bioinformatics resources. After that, the formula–herb–compound–target–pathway network was constructed to explore the mechanism of ZXGD in the treatment of CHD. Finally, molecular docking and the vitro experiment were carried out to validate some key targets. As a result, a total of 39 compounds, 12 core targets, and 4 pathways contributed to ZXGD for the treatment of CHD. This study preliminarily provided a foundation for the study on the mechanism against CHD for ZXGD and may be a reference for the compatibility mechanism and the extended application of TCM compound prescription.

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The young fruit of Citrus aurantium L. or Citrus sinensis Osbeck as a natural health food: A deep insight into the scientific evidence of its health benefits

Luo

Yuan

Mao

et al. 2023

Arabian Journal of Chemistry

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Meranzin hydrate elicits antidepressant effects and restores reward circuitry

Cited by 12 publications

References 56 publications

Study on the Active Constituents and Molecular Mechanism of Zhishi Xiebai Guizhi Decoction in the Treatment of CHD Based on UPLC-UESI-Q Exactive Focus, Gene Expression Profiling, Network Pharmacology, and Experimental Validation

The young fruit of Citrus aurantium L. or Citrus sinensis Osbeck as a natural health food: A deep insight into the scientific evidence of its health benefits

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