Méprobamate et morphine

Frommel, E; Fleury, C; Schmidt-Ginzkey, J

doi:10.1159/000134775

Cited by 3 publications

(3 citation statements)

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“…However, analgesic effects with low doses of morphine have been reported using grid shock (124) and ultrasonic pain stimulation (125) in rats and with the jaw-jerk response to electrical stimulation of the tooth pulp in dogs and cats (1%). Sympathomimetic compounds have shown analgesic eflects, with ACTH and cortisone causing an elevated pain threshold, measured by thermal stimulation of mice on a hot plate (127), and with amphetamine and norepinephrine (NE) likewise causing an elevated pain threshold, measured by the inflamed-foot method in rats (128) Jozrriinl o j Phnrwjnceziticnl Science$ and by electric shock to the tooth pulp in guinea pigs (129). Most tests of analgesia have been hased on a iriotor response of flinching, withdrawal, or vocalization.…”

Section: Avoidance By Running--a Test Apparatusmentioning

confidence: 99%

Drug Effects on Animal Performance and the Stress Syndrome

Barry

Buckley

1966

Journal of Pharmaceutical Sciences

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Section: Avoidance By Running--a Test Apparatusmentioning

confidence: 99%

Drug Effects on Animal Performance and the Stress Syndrome

Barry

Buckley

1966

Journal of Pharmaceutical Sciences

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“…Frequent occurrences of serious side-effects, however, decrease its clinical usefulness. EPA appears to be as potent an antiepileptic drug as PA and has fewer toxic side-effects; it is marketed extensively outside of North America and is considered a clinically useful and accepted anticonvulsant (7). nylhydantoin and the carbonyl oxygen and trigonal nitrogen in diazepam) also occupy similar regions in space.…”

mentioning

confidence: 99%

Ethylphenacemide and phenacemide: conformational similarities to diphenylhydantoin and stereochemical basis of anticonvulsant activity.

Camerman¹,

Camerman²

1977

Proc. Natl. Acad. Sci. U.S.A.

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The three-dimensional molecular structures of the potent anticonvulsant agents phenacemide and ethylphenacemide have been determined by single-crystal x-ray diffraction. Although these compounds possess straight-chain acetylurea groupings, in the crystalline state both molecules adopt a pseudocyclic conformation of the acetylurea chain through amide.carbonyl oxygen intramolecular hydrogen bonding. This results in spatial positioning and relative orientation of two electron-donating functional groups in these molecules similar to those of comparable atoms in diphenylhydantoin and other heterocycle-containing anticonvulsants. Despite much investigation, the mechanisms of action of anticonvulsant drugs are not clearly understood. Widespread research has led to numerous theories which ascribe their central nervous system activity to various physicochemical properties, but none of these has so far proved satisfactory. We have undertaken three-dimensional structural determinations of chemically diverse compounds with clinically or laboratory-demonstrated efficacy against grand mal epilepsy to discover if anticonvulsant action can be correlated with specific molecular stereochemistry.Previously our studies (1)

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“…It seems established that chlorpromazine, besides having an analgesic action of its own, exerts a potentiating action on morphine, when both drugs are simultaneously injected in laboratory animals, as has been described by Courvoisier, Fournel, Ducrot, Kolsky and Koetschet (1953), Schneider (1954), Frommel and Fleury (1959), though Kopera and Armitage (1954) were unable to demonstrate such an action using 1.5 mg./kg. morphine sulphate and 10 mg./kg.…”

mentioning

confidence: 86%

Analgesic Action of Chlorpromazine and Reserpine in Relation to that of Morphine

Leme¹,

Silva²

1961

Journal of Pharmacy and Pharmacology

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An analgesic action of reserpine is reported in mice. This effect, detected by the hot-plate method, is of little, or only of moderate intensity, in the first 2 hr. after injection; maximal intensity is obtained 48-72 hr. after the injection of the drug, and then decreases gradually ; after 144 hr. injected animals behave again like controls. The analgesic effect of reserpine seems to differ from that shown by morphine or that shown by chlorpromazine which is quicker in onset and disappears in a few hours. Reserpine potentiates the analgesic action of morphine. This potentiation can be observed 2 hr. after the injection of reserpine. The early potentiating period is followed by a later period of summation of effects. Since a short interval after the injection, reserpine does not exert any analgesic effect, but is able to potentiate morphine analgesia, this action has been regarded as a direct one; the later period of analgesia and summation of effects with morphine has been interpreted as an indirect action of the drug.

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Méprobamate et morphine

Cited by 3 publications

References 0 publications

Drug Effects on Animal Performance and the Stress Syndrome

Drug Effects on Animal Performance and the Stress Syndrome

Ethylphenacemide and phenacemide: conformational similarities to diphenylhydantoin and stereochemical basis of anticonvulsant activity.

Analgesic Action of Chlorpromazine and Reserpine in Relation to that of Morphine

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