Mephentermine—An effective pressor amine

Brofman, Bernard L.; Hellerstein, Herman K.; Caskey, Walter H.

doi:10.1016/0002-8703(52)90261-5

Cited by 32 publications

(5 citation statements)

References 12 publications

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“…An 80% mortality has been reported in shock following acute cardiac infarction (Hellerstein et al, 1952;Griffith et al, 1954). However, this figure is probably an underestimate, as it is based on hospital experience alone.…”

Section: Seniior Medical Registrar the Middlesex Hospital Lonidonmentioning

confidence: 99%

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Treatment of Cardiac Shock by Metaraminol

Besterman¹

1959

BMJ

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Section: Seniior Medical Registrar the Middlesex Hospital Lonidonmentioning

confidence: 99%

“…Mephentermine sulphate has been used successfully in the treatment of cardiac shock by Brofman et al (1952), Hellerstein et al (1952, and Garai and Smith (1958). This drug may be given by injection or by drip, and causes a rise in systemic pressure and an increased coronary blood flow.…”

Section: Seniior Medical Registrar the Middlesex Hospital Lonidonmentioning

confidence: 99%

Treatment of Cardiac Shock by Metaraminol

Besterman¹

1959

BMJ

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“…In 1910, Barger and Dale provided insightful information on the sympathomimetic actions of the amines and how these actions related to their chemical structures (Barger & Dale, 1910). Experiments conducted with dogs (Brofman, Hellerstein, & Caskey, 1952;Eckstein & Abboud, 1962;Welch, Braunwald, Case, & Sarnoff, 1958) and cats (Swaine, Perlmutter, & Ellis, 1964) have demonstrated that mephentermine is both an α-and a β-adrenergic receptor agonist (Hodge & Dornhorst, 1966) and acts directly and indirectly by releasing NE from its storage sites (Westfall & Westfall, 2006) located at the presynaptic nerve terminals. In turn, NE increases vascular tone (arteries and veins) and exerts positive inotropic and chronotropic effects on the heart.…”

Section: Introductionmentioning

confidence: 99%

“…Mephentermine has been reported to be a safe compound to be administered to humans (Kansal et al., ) and dogs as no side effects were observed when cerebral activity, pupillary changes, blood glucose, respiratory rate, and metabolic rate were evaluated (Brofman et al., ). However, despite its routine administration, reports on the effects of mephentermine on the hemodynamics of cattle are lacking.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of a mephentermine‐based product as a vasopressor and a cardiac performance enhancer when given intramuscularly to cattle

Cunha¹,

Río

Youngblood

et al. 2017

Vet Pharm & Therapeutics

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The goal of this study was to confirm the vasopressor and cardiac effects of POTENAY INJETÁVEL (POT), a mephentermine-based product, given to cattle with induced vascular/cardiac depression. Ten healthy Holstein cattle (206 ± 13 kg) followed a randomized-complete-block design (RCBD) utilizing crossover study design. Each animal randomly received (1 ml/25 kg, IM) of either POT (n = 10) or volume-matched placebo control (0.9%NaCl, CP, n = 10). A subset of animals (n = 5) received POT first (day 0) while the remaining (n = 5) received CP; after a six-day washout period, cattle received the opposite compound. Animals were anesthetized and catheterized for systemic/left ventricular hemodynamic monitoring. Myocardial dysfunction/hypotension was induced by increasing the end-tidal isoflurane concentration until arterial blood pressure was 20% lower than at baseline and remained stable. Once the animal was determined to be hypotensive and hemodynamically stable, steady-state hypotensive baseline data (BL2) were acquired, and treatment with either POT or CP was given. Data were acquired post-treatment at every 15 min for 90 min. POT improved cardiac output (+68 L/min, ±14%, p < 0.05), MAP (+14 mmHg, ±4%, p < 0.05), HR (+22 bpm, ±8%, p < 0.05), and peak rates of ventricular pressure change during both systole (dP/dt : +37 mmHg/s ±13%, p < 0.05) and diastole (dP/dt : +31 mmHg/s, ±7%, p < 0.05). No improvements were noted following placebo-control administration. Results indicate that POT improves cardiac performance and systemic hemodynamics in cattle with induced cardiovascular depression when given as single intramuscular injection.

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“…It causes pupillary dilatation, is not anesthetic when applied topically to the cornea, is weakly spasmolytic for smooth muscle of intestine, and has no effect on tracheal cilia. attention toward characterizing its cardiac effects both in animals (2-4) and in patients suffering from shock accompanying myocardial infarction (5)(6)(7)(8). The purpose of this paper is to present additional laboratory data to define further the pharmacological properties of this agent and to compare its actions with those of amphetamine sulfate, d-desoxyephedrine hydrochloride, and 2-eohedrine hvdrochloride.…”

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confidence: 99%