Pharmacological Properties of Mephentermine, a Sympathomimetic Amine*

The Effect of Sympathomimetic Amines on Femoral Arterial Blood Flow in the Cat

“…Moreover, Glover & Shanks (1963) have shown that dichloroisoprenaline prevented both the initial and after-dilatations produced by adrenaline but did not prevent the rise in venous lactic acid concentration. The fact that intra-arterial mephentermine produces dilatation is also against Lundholm's hypothesis since this amine has little metabolic activity (Eckfeld, Abell & Seifter, 1954).…”

Efficacy of a mephentermine‐based product as a vasopressor and a cardiac performance enhancer when given intramuscularly to cattle

“…The basic chemical structure of natural amines consists of an aromatic group (benzene ring) and an aliphatic side chain with an amino group (ethylamine) (Eckstein & Abboud, 1962). Mephentermine, an N-methylω-phenyltertiarybutylamine, is unique for not having an asymmetric carbon atom and consequently a d-or I-form (Eckfeld, Abell, & Seifter, 1954).…”

“…Information on how mephentermine directly affects the biomolecular targets within the cells compared to the other sympathomimetic amines (such as dobutamine and dopamine) is lacking, although some assumptions may be accurate considering these are all within the same class of drugs (Eckfeld et al., ). These agents cause stimulation of the membrane‐bound β receptor to activate adenyl cyclase, leading to cAMP production and subsequent phosphorylation of calcium channels on the sarcolemma of the myocyte membrane and sarcoplasmic reticulum.…”

A Clinical Evaluation of Mephentermine Sulfate and Pentylenetetrazol as Stimulant Therapy for the Geriatric Patient

“…It was the opinion of the investigators that there was no evidence of habituation or untoward reactions coincident with long‐term therapy. Mephentermine has approximately one‐third to one‐half the potency of amphetamine or desoxyephedrine as a cerebral stimulant for chicks, cats or dogs (5). By means of determining the LD 50 in mice, it was found that mephentermine was two‐thirds as toxic as amphetamine or desoxyephedrine and three times more toxic than ephedrine (6).…”