Meperidine versus valethamate bromide in shortening the duration of active labor

Yılmaz, Bülent; Kart, Cavit; Kelekçi, Sefa; Göktürk, Umut; Süt, Necdet; Tarlan, Nurten; Mollamahmutoğlu, Leyla

doi:10.1016/j.ijgo.2009.06.021

Cited by 17 publications

(19 citation statements)

References 20 publications

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“…[1–3] Also, meperidine was shown to promote cervical effacement during labor[4] and to shorten the duration of active labor in nulliparous women with a singleton pregnancy at term. [5]…”

Section: Introductionmentioning

confidence: 99%

Epidural analgesia during labor vs no analgesia: A comparative study

2012

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Background:Epidural analgesia is claimed to result in prolonged labor. Previous studies have assessed epidural analgesia vs systemic opioids rather than to parturients receiving no analgesia. This study aimed to evaluate the effect of epidural analgesia on labor duration compared with parturients devoid of analgesia.Methods:One hundred sixty nulliparous women in spontaneous labor at full term with a singleton vertex presentation were assigned to the study. Parturients who request epidural analgesia were allocated in the epidural group, whereas those not enthusiastic to labor analgesia were allocated in the control group. Epidural analgesia was provided with 20 mL bolus 0.5% epidural lidocaine plus fentanyl and maintained at 10 mL for 1 h. Duration of the first and second stages of labor, number of parturients receiving oxytocin, maximal oxytocin dose required for each parturient, numbers of instrumental vaginal, vacuum-assisted, and cesarean deliveries and neonatal Apgar score were recorded.Results:There was no statistical difference in the duration of the active-first and the second stages of labor, instrumental delivery, vacuum-assisted or cesarean delivery rates, the number of newborns with 1-min and 5-min Apgar scores less than 7 between both groups and number of parturients receiving oxytocin, however, the maximal oxytocin dose was significantly higher in the epidural group.Conclusion:Epidural analgesia by lidocaine (0.5%) and fentanyl does not prolong labor compared with parturients without analgesia; however, significant oxytocin augmentation is required during the epidural analgesia to keep up the aforementioned average labor duration.

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“…[1–3] Also, meperidine was shown to promote cervical effacement during labor[4] and to shorten the duration of active labor in nulliparous women with a singleton pregnancy at term. [5]…”

Section: Introductionmentioning

confidence: 99%

Epidural analgesia during labor vs no analgesia: A comparative study

2012

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“…Several trials in the obstetric literature have addressed the efficacy of antispasmodics in reducing the length of the first stage of labor. A Medline search of the English language literature for the period 1937 to February 2011, using as search terms ‘antispasmodics’, ‘spasmolytics’, ‘labor’, ‘augmentation’ and ‘delivery’ alone or in combination, identified 12 comparative trials on the administration of antispasmodics in labor (8–18). We also cross‐checked the references of all selected articles to identify other potentially relevant reports.…”

Section: Discussionmentioning

confidence: 99%

“…Use of anticholinergics/antispasmodics as a method of augmenting labor was first described in 1937 by Hirsch (4), who reported a decrease in labor length by two to four hours following intrapartum administration of an atropine‐like drug (Syntropan®), mainly among older nulliparas. Since then, the popularity of antispasmodics for reducing the duration of labor has varied over time, becoming a routine obstetric intervention in many maternity units throughout the Western world and in parts of the developing world (5–18). Placebo‐controlled randomized trials of different types of antispasmodics used to shorten the length of labor yielded mixed results, with notable success among certain study populations (8–14,16,18) and no appreciable effect in others (7,15,17).…”

Section: Introductionmentioning

confidence: 99%

“…Since then, the popularity of antispasmodics for reducing the duration of labor has varied over time, becoming a routine obstetric intervention in many maternity units throughout the Western world and in parts of the developing world (5–18). Placebo‐controlled randomized trials of different types of antispasmodics used to shorten the length of labor yielded mixed results, with notable success among certain study populations (8–14,16,18) and no appreciable effect in others (7,15,17). However, heterogeneity in study designs, type of medication and administration route, choice and measurement of outcomes, as well as variation in geographic practice patterns and healthcare settings, pose a significant challenge to the interpretation of results.…”

Section: Introductionmentioning

confidence: 99%

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Use of an antispasmodic (rociverine) to shorten the length of labor: a randomized, placebo‐controlled trial

Cromi

Ghezzi

Agosti

et al. 2011

Acta Obstet Gynecol Scand

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“…[2–5] But, the effect is not seen consistently and two trials have found no significant effect with the use of this drug. [67]…”

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confidence: 99%

Valethamate bromide: Conflicting evidence and continuing use

Sharmila

2010

Journal of Pharmacology and Pharmacotherapeutics

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We read the editorial 'Valethamate bromide: Is there any proof of efficacy and safety for its use in labour?' by author Gitanjali B, with interest. [1] The editorial excellently describes the inadequate literature and unconvincing evidence regarding the use of valethamate bromide for cervical ripening and dilatation in labor. However, with due respect to the author, we would like to raise certain points. Firstly, we feel that the article is more biased and judgmental rather than being open to all currently available evidence. Contradictory to what is stated in the article, many clinical trials have shown that valethamate bromide is effective in facilitating cervical ripening, dilatation and thereby decreasing the duration of labor. [2][3][4][5] But, the effect is not seen consistently and two trials have found no significant effect with the use of this drug. [6,7] We also wish to differ regarding the first of the three reasons suggested by the author for using this drug, which states 'that it is beneficial in crowded labor rooms to facilitate the reduction in time spent monitoring patient rather than a sound medical reason'. The most important reason for using this drug is to facilitate the labor process and reducing labor duration with an ultimate aim of reducing fetomaternal complications secondary to delayed or nonprogressive labor.

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Meperidine versus valethamate bromide in shortening the duration of active labor

Abstract: Meperidine, but not valethamate bromide, significantly shortened the duration of active labor in nulliparous women with a singleton pregnancy at term.

Cited by 17 publications

References 20 publications

Epidural analgesia during labor vs no analgesia: A comparative study

Epidural analgesia during labor vs no analgesia: A comparative study

Use of an antispasmodic (rociverine) to shorten the length of labor: a randomized, placebo‐controlled trial

Valethamate bromide: Conflicting evidence and continuing use

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