Use of an antispasmodic (rociverine) to shorten the length of labor: a randomized, placebo‐controlled trial

Cromi, Antonella; Ghezzi, Fabio; Agosti, Massimo; Uccella, Stefano; Piazza, Nicoletta; Serati, Maurizio; Bolis, Pierfrancesco

doi:10.1111/j.1600-0412.2011.01265.x

Cited by 6 publications

(5 citation statements)

References 20 publications

(44 reference statements)

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“…Modern labor management protocols contain interventions that can directly or indirectly affect the duration of labor, such as epidural analgesia, amniotomy, and oxytocin administration [3]. Unlike amniotomy and oxytocin augmentation, drotaverine hydrochloride does not enhance myometrial contractility; hence, it does not induce uterine hyperstimulation or compromise fetomaternal outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…Minimizing the duration of labor without compromising fetomaternal wellbeing is a desirable outcome in all labor and delivery units [1]. Prolonged labor has been associated with higher rates of neonatal admission to the intensive care unit [2], and is likely to increase the work burden, especially in busy labor wards, with consequent inadequacy of obstetric care [3].…”

Section: Introductionmentioning

confidence: 99%

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Drotaverine to improve progression of labor among nulliparous women

Ibrahim¹,

Alzeeniny²,

Ellaithy³

et al. 2013

International Journal of Gynecology & Obstetrics

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Drotaverine to improve progression of labor among nulliparous women

Ibrahim¹,

Alzeeniny²,

Ellaithy³

et al. 2013

International Journal of Gynecology & Obstetrics

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“…Studies indicate that atropine, which is a broad-spectrum anticholinergic drug, is associated with reducing active phase of labor, total length of labor, and an increase in cesarean sections, and side effects like dry mouth, tachycardia, and urinary retention might appear [14]. In multiple studies of antispasmodic drugs used in labor [15][16][17][18][19][20][21][22][23][24][25], hyoscine is an antimuscarinic medication (anticholinergic and antispasmodic) and competes with the action of acetylcholine on muscarinic receptors. It is helpful in reducing the types of spasms and is known under other commercial brands as scopolamine, HBB, and Buscopan, and its pregnancy category is C [26].…”

Section: This Article Is Part Of the Topical Collection On Medicinementioning

confidence: 99%

The Effect of Intramuscular Hyoscine and Hyoscine-Promethazine on the Duration of Labor in Nulliparous Pregnant Women (Triple-Blind Randomized Controlled Trial)

shafaie

Shahmohammadi

Jafarabadi

et al. 2018

SN Compr. Clin. Med.

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Childbirth consists of a three-stage period beginning with uterine, contractions, and ending in the expulsion of the placenta. The aim of this study was the effect of intramuscular hyoscine and hyoscine-promethazine on the duration of labor in nulliparous pregnant women. This study was a triple-blind clinical trial on 213 nulliparous pregnant women who had referred to Amiralmomenin hospital in Zanjan, Iran. Selection of samples was random and done with using 3, 6(1:1:1) of blocking ratio. This study had three groups. The first group received 20 mg hyoscine (group A), the second group 3 cc sterile water (group B), and the third group 20 mg hyoscine and 25 mg promethazine (group C). Data collection tools included a demographic questionnaire, checklist of data, and partograph chart. The mean of the first stage of labor in hyoscine group was 88.95 ± 51.07 min, hyoscine-promethazine 100.05 ± 65.88 min, and control group 170.37 ± 106.87 min. There was significant correlation between A and C and B and C groups (P < 0.001). The mean of the second stage in group A was 46.37 ± 44.60, group B 32.25 ± 17.74, and control group 55.05 ± 44.44 min and a significant relationship was between B and C groups (P = 0.03). The results showed that hyoscine and hyoscine-promethazine can be used to reduce the duration of labor.

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“…The safety of active management of labour has been demonstrated by several prospective randomized control trial [6] . A shorter duration of labour from admission to delivery has been consistently reported in numerous studies of women treated with active management protocol [5][6][7] . However, prolonged labour still occurs [2,3] .…”

Section: Introductionmentioning

confidence: 99%

Metoclopramide Versus Hyosine Butyl-Bromide in Shortening Duration of First Stage of Labour Among Nulliparous Women in Abakaliki, Ebonyi State

UWAKWE,

DARLINTON-PETER CHIBUZOR,

ORTUANYA

et al. 2024

ijirms

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Background: Administering antispasmodics during labour could lead to faster and more effective dilatation of the cervix preventing prolonged labour. However, due to scarce information on it, with no generally agreed protocol for its use in labour. This study is aimed to see if we can have more positive findings to support the existing literature for probable consideration as a protocol in labour management. Methodology: This was equivalence, open label; placebo controlled randomized trial among nulliparous women over a six months period. Eligible participants were randomized to receive a slow intravenous medication of one of these three medications-Metoclopramide (10mg), Hyoscine Bromide (20mg) or placebo. They were managed according to the institutional intrapartum protocol. Primary outcome was the duration of first stage of labour. Secondary outcome includes the rate of cervical dilatation, total duration of labour, route of delivery and Apgar score at 5th minute. Data was analysed with SPSS, version 25.0 (2017, SPSS Inc., Chicago IL, USA) and by the concept of intention to treat protocol. P-value of less than 0.05 was taken as significant. Results: Sixty women were included in the metoclopramide group, 59 women in the hyoscine bromide group and 61 women in the placebo group. There was statistically significant difference in the mean reduction of the first stage of labour (263.84±139.44mins=Metoclopramide), (Hyoscine Bromide=241.33±121.56mins) and (placebo = 318.43±203.44mins). The total mean duration of labour was significantly significant different among the groups (P<0.05), (295.86±138.7 = Metoclopramide, (271.69±122.35 = hyoscine butyl bromide) and (350.24±201.48 = placebo). There are no statistically significant differences among other variables studied. Conclusion: Metoclopramide is as effective as hyoscine butyl bromide in shortening duration of first stage of labour in nulliparous women with no recorded adverse effect. I recommend that they should be introduced as part of the protocol in active management of labour. Clinical Trial.gov: NCT05222646

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Use of an antispasmodic (rociverine) to shorten the length of labor: a randomized, placebo‐controlled trial

Abstract: Intrapartum administration of rociverine to nulliparous women may help to reduce the duration of the first stage of labor in a context of uniform labor management.

Cited by 6 publications

References 20 publications

Drotaverine to improve progression of labor among nulliparous women

Drotaverine to improve progression of labor among nulliparous women

The Effect of Intramuscular Hyoscine and Hyoscine-Promethazine on the Duration of Labor in Nulliparous Pregnant Women (Triple-Blind Randomized Controlled Trial)

Metoclopramide Versus Hyosine Butyl-Bromide in Shortening Duration of First Stage of Labour Among Nulliparous Women in Abakaliki, Ebonyi State

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