Meperidine-halothane interaction in dogs

Steffey, Eugene; Martucci, Richard W.; Howland, D.; Asling, Joseph H.; Eisele, John H.; Hirsch, Calvin H.

doi:10.1007/bf03005450

Cited by 23 publications

(17 citation statements)

References 10 publications

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“…To accomplish this, the aforementioned technique used to determine MAC was modified in accordance with techniques reported elsewhere. 3,5,22 However, because of the behavior of horses in response to opioid injections, further modification of the technique was required soon after starting these experiments. In the study reported here, we injected MOR, but ISO concentration was not altered as in our previous studies of anesthetic adjuvant drugs.…”

Section: Methodsmentioning

confidence: 99%

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Interactions of morphine and isoflurane in horses

Steffey

Eisele

Baggot

2003

ajvr

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Section: Methodsmentioning

confidence: 99%

“…Drugs of this class are frequently used in combination with inhalation anesthetics, and because of their analgesic potency, they permit reduction of the dose of inhalation anesthetic otherwise required. [1][2][3][4][5] Reduction of the dose of inhalation anesthetic generally promotes further cardiovascular stability and improved perianesthetic care.…”

mentioning

confidence: 99%

Interactions of morphine and isoflurane in horses

Steffey

Eisele

Baggot

2003

ajvr

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“…Because ACE activity was inhibited in both groups, we initially believed that this was caused by excitation of the cats during the measurement of blood pressure prior to the induction of anesthesia; however, the remarkable decrease in blood pressure following application of the anesthetic clearly indicated inhibition of ACE activity. The anesthetic isoflurane decreases aortic systolic blood pressure, cardiac output, and vascular resistance in a dose-dependent manner [14]. Isoflurane is known to cause hypotension during anesthesia because hypotension can be ameliorated by terminating delivery of the anesthetic.…”

mentioning

confidence: 99%

Effect of Isoflurane Anesthesia on Hemodynamics Following the Administration of an Angiotensin-Converting Enzyme Inhibitor in Cats

Ishikawa¹,

Uechi

Ishikawa³

et al. 2007

J. Vet. Med. Sci.

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ABSTRACT. The objective of this study was to evaluate the hemodynamics of the anesthetic isoflurane in healthy cats given angiotensinconverting enzyme inhibitor (ACEI). The 7 healthy young cats and 3 old cats were received placebo or enalapril 0.5 mg/kg orally. The change in systolic arterial pressure from the baseline to 30 min postanesthesia in the ACEI group was significantly higher than in the placebo group (mean ± SD: -39 ± 13% vs. -17 ± 12%, respectively). The present study indicated that general anesthesia may induce hypotension after the administration of an ACEI.

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“…Following the administration of intramuscular pethidine 2.75 mg/kg, concentrations were lower in awake dogs than in those anaesthetised by halothane (Steffey et al 1977). However, the estimated half-lives did not differ significantly, being approximately 26.5 and 35 min, respectively.…”

Section: Pethidinementioning

confidence: 80%

Pharmacokinetic Drug Interactions in Anaesthetic Practice

Wood

1991

Clinical Pharmacokinetics

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Patients receive on average 10 different drugs while in hospital; when fewer than 6 are administered the probability of an adverse drug interaction is about 5%, but when more than 15 are given the probability increases to over 40%. Patients presenting for anaesthesia and surgery are likely to receive multiple preoperative drug therapy and also many perioperative medications as part of their anaesthetic regimen. Thus, there is a considerable potential for interactions to occur in anaesthetic practice. Pharmacokinetic interactions occur when the administration of 1 drug alters the disposition of another, and hence alters the concentration of drug at the receptor site, leading to altered drug response. These changes in drug concentration at the receptor site may be produced by alteration of (a) drug absorption and uptake into the body, (b) drug distribution, (c) drug metabolism and (d) drug elimination or excretion by nonmetabolic routes. Interactions affecting the absorption of orally administered medications are often due to the indirect effect of 1 drug on gastric motility and emptying, which leads to reduced, delayed or variable systemic drug availability. Gastric emptying time before elective surgery is normal, but premedication with morphine, pethidine (meperidine) and anticholinergics all delay gastric emptying and hence drug absorption. Inhalational anaesthesia of short duration does not appear to affect drug absorption, although halothane anaesthetic used for longer periods produces a slight delay in gastric emptying. Volatile anaesthetics have been shown to delay the intramuscular absorption of ketamine. Anaesthetic agents may affect drug distribution, and peak concentrations of propranolol, for example, are 4 times higher during halothane anaesthesia in dogs, accompanied by a marked decrease in volume of distribution. This effect has been noted for other drugs, including thiopental and verapamil. Volatile anaesthetics also affect plasma protein binding, leading to displacement interactions in some cases. Volatile anaesthetics affect the metabolism of concomitantly administered drug (a) by altering the rate of delivery to the organ of clearance (e.g. decreasing hepatic blood flow) and (b) by altering the activity of drug metabolising enzymes. It is now well recognised that all the volatile anaesthetics currently in use inhibit the metabolism of a large variety of drugs, e.g. propranolol, lidocaine (lignocaine), fentanyl and pethidine. Other examples of interactions of clinical importance to anaesthesiologists include those between cimetidine and the local anaesthetics and benzodiazepines; inhibition of plasma cholinesterase by drugs such as ecothiopate; interactions between monoamine oxidase inhibitors and sympathomimetics or pethidine and between monoamine oxidase inhibitors and sympathomimetics or pethidine and between isoniazid and enflurane.(ABSTRACT TRUNCATED AT 400 WORDS)

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Meperidine-halothane interaction in dogs

Cited by 23 publications

References 10 publications

Interactions of morphine and isoflurane in horses

Interactions of morphine and isoflurane in horses

Effect of Isoflurane Anesthesia on Hemodynamics Following the Administration of an Angiotensin-Converting Enzyme Inhibitor in Cats

Pharmacokinetic Drug Interactions in Anaesthetic Practice

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