Effect of Isoflurane Anesthesia on Hemodynamics Following the Administration of an Angiotensin-Converting Enzyme Inhibitor in Cats

Abstract

ABSTRACT. The objective of this study was to evaluate the hemodynamics of the anesthetic isoflurane in healthy cats given angiotensinconverting enzyme inhibitor (ACEI). The 7 healthy young cats and 3 old cats were received placebo or enalapril 0.5 mg/kg orally. The change in systolic arterial pressure from the baseline to 30 min postanesthesia in the ACEI group was significantly higher than in the placebo group (mean ± SD: -39 ± 13% vs. -17 ± 12%, respectively). The present study indicated that general anesthesia may induce hypotension after the administration of an ACEI.

Effects of orally administered enalapril on blood pressure and hemodynamic response to vasopressors during isoflurane anesthesia in healthy dogs

“…These findings are similar to those described in human patients undergoing both cardiac and noncardiac surgeries (Coriat et al 1994;Brabant et al 1999a;Colson et al 1999;Bertrand et al 2001;Comfere et al 2005;Auron et al 2011) and in healthy anesthetized cats (Ishikawa et al 2007) and dogs . In a study in which human patients receiving one of two ACEi were randomized to continue or withdraw from these medications on Figure 1 Mean AE standard deviation systolic (SAP), diastolic (DAP) and mean (MAP) arterial blood pressure at an end-tidal isoflurane concentration of 1.3% in 12 healthy adult dogs treated with one of 3 week-long pre-anesthetic protocols: oral placebo every 12 hours with the 15th dose administered approximately 90 minutes prior to anesthetic induction (PLA); oral enalapril, 0.5 mg kg À1 every 12 hours, with the 15th dose withheld on the day of anesthesia (ENA-W), and oral enalapril, 0.5 mg kg À1 every 12 hours, with the 15th dose administered approximately 90 minutes prior to anesthetic induction (ENA).…”

“…One prospective study of healthy cats showed greater reductions in post‐induction systolic BP among young cats in which enalapril was administered 3 hours prior to induction in comparison with those treated with placebo (Ishikawa et al. ). A study in healthy dogs and dogs with mitral insufficiency reported similar findings; however, to date, these data have been presented only in abstract form (Uechi et al.…”

Cryopreservation of feline epididymal spermatozoa from dead and alive animals and its use in assisted reproduction

“…In order to restrain all cats, atropine sulphate (0.025 mg/kg) was administered intramuscularly as a premedication; anesthesia was induced by 6 mg/kg propofol and maintained by isofluorane after endotracheal intubation. An anaesthetic density of 1.9% isofluorane provided the necessary anesthetic depth (Ishikawa et al ., 2007).…”

“…An anaesthetic density of 1.9% isofluorane provided the necessary anesthetic depth (Ishikawa et al, 2007).…”